Potential metabolic and behavioural roles of the putative endocannabinoid receptors GPR18, GPR55 and GPR119 in feeding
Data up to Jan 2025
Total Citations Per Year
Abstract
References (165)
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013
2014 • 11,355 citations
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 • 8,261 citations
Extension of Bilbro-McMillan Charge Density Wave-Superconductivity coexistence relation to quantum régimes: application to superconducting domes around quantum critical points
2015 • 3,338 citations
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
1995 • 2,837 citations
Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response
2014 • 2,619 citations
Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein
1997 • 1,835 citations
Leptin-regulated endocannabinoids are involved in maintaining food intake
2001 • 1,557 citations
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
2005 • 1,509 citations
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1and CB2
2010 • 1,507 citations
Proceedings of the National Academy of Sciences
2024 • 1,483 citations
Effects of Rimonabant on Metabolic Risk Factors in Overweight Patients with Dyslipidemia
2005 • 1,380 citations
Effect of Rimonabant, a Cannabinoid-1 Receptor Blocker, on Weight and Cardiometabolic Risk Factors in Overweight or Obese Patients
2006 • 1,226 citations
From Lesions to Leptin
1999 • 1,165 citations
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
1998 • 1,136 citations
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
2003 • 1,123 citations
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
2005 • 1,057 citations
Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
2004 • 975 citations
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
2000 • 878 citations
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor
2015 • 832 citations
Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation
2011 • 826 citations
Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition
1997 • 806 citations
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
2008 • 658 citations
Características inmunológicas claves en la fisiopatología de la sepsis. Infectio
2015 • 658 citations
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
2006 • 626 citations
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors
2017 • 579 citations
The pharmacology of cannabinoid receptors and their ligands: an overview
2006 • 513 citations
Mitochondrial CB1 receptors regulate neuronal energy metabolism
2012 • 507 citations
A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding
2002 • 489 citations
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats
2001 • 469 citations
A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1
1997 • 457 citations
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
2010 • 419 citations
Novel cannabinoid receptors
2007 • 406 citations
A Total Synthesis of dl-Δ1-Tetrahydrocannabinol, the Active Constituent of Hashish1
1965 • 381 citations
Hypothalamic POMC neurons promote cannabinoid-induced feeding
2015 • 370 citations
Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding
2015 • 364 citations
Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor
2004 • 344 citations
Brain Regulation of Appetite and Satiety
2008 • 341 citations
An archaeological and historical account of cannabis in China
1973 • 331 citations
Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance
2012 • 309 citations
The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System
2008 • 292 citations
Spatio-Temporal Analysis of On Demand Transit: A Case Study of Belleville, Canada
2020 • 290 citations
A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release
2007 • 286 citations
Multiple pathways involved in the biosynthesis of anandamide
2007 • 286 citations
The enigmatic pharmacology of GPR55
2009 • 280 citations
Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
1999 • 276 citations
Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period
1999 • 273 citations
Expression of Cannabinoid CB1 Receptors by Vagal Afferent Neurons Is Inhibited by Cholecystokinin
2004 • 272 citations
Bimodal control of stimulated food intake by the endocannabinoid system
2010 • 269 citations
Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors
2018 • 260 citations
Distribution of pancreatic polypeptide and peptide YY
2002 • 254 citations
Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression
2009 • 254 citations
Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory
1988 • 249 citations
Cannabinoid activation of peroxisome proliferator-activated receptors: Potential for modulation of inflammatory disease
2009 • 239 citations
Dietary Linoleic Acid Elevates Endogenous 2‐AG and Anandamide and Induces Obesity
2012 • 236 citations
Δ9‐Tetrahydrocannabinol and N‐arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC‐1B cells
2011 • 232 citations
Integration of Endocannabinoid and Leptin Signaling in an Appetite-Related Neural Circuit
2005 • 231 citations
The Religious and Medicinal Uses ofCannabisin China, India and Tibet
1981 • 230 citations
Receptors for acylethanolamides—GPR55 and GPR119
2009 • 225 citations
The psychiatric side-effects of rimonabant
2009 • 218 citations
Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice
1998 • 217 citations
Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis
2009 • 214 citations
Energy Density of Foods: Effects on Energy Intake
2000 • 212 citations
Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2
2003 • 211 citations
CB1 cannabinoid receptor‐mediated modulation of food intake in mice
2005 • 207 citations
Endocannabinoid system and mood disorders: Priming a target for new therapies
2012 • 202 citations
Efficacy and Safety of Rimonabant for Improvement of Multiple Cardiometabolic Risk Factors in Overweight/Obese Patients
2008 • 196 citations
Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin.
1998 • 187 citations
Control of Human Appetite: Implications for The Intake of Dietary Fat
1996 • 181 citations
Cannabidivarin‐rich cannabis extracts are anticonvulsant in mouse and rat via a <scp>CB1</scp> receptor‐independent mechanism
2013 • 180 citations
Evolutionary origins of the endocannabinoid system
2006 • 175 citations
GPR119 as a fat sensor
2012 • 170 citations
Y4 receptor knockout rescues fertility in ob/ob mice
2002 • 166 citations
Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors
2017 • 164 citations
Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
2011 • 164 citations
A catalytically silent FAAH-1 variant drives anandamide transport in neurons
2011 • 164 citations
Peripheral, but Not Central, CB1 Antagonism Provides Food Intake–Independent Metabolic Benefits in Diet-Induced Obese Rats
2008 • 155 citations
GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis
2009 • 155 citations
The evolution and comparative neurobiology of endocannabinoid signalling
2012 • 154 citations
Cannabis: Effects on hunger and thirst
1975 • 154 citations
Delta‐9‐tetrahydrocannabinol delays the gastric emptying of solid food in humans: a double‐blind, randomized study
1999 • 152 citations
An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
2017 • 151 citations
The<scp>l</scp>-α-Lysophosphatidylinositol/GPR55System and Its Potential Role in Human Obesity
2011 • 150 citations
Activation of <scp>GPR</scp>18 by cannabinoid compounds: a tale of biased agonism
2014 • 143 citations
Expression cloning of a human brain neuropeptide Y Y2 receptor
1996 • 142 citations
Endogenous cannabinoids revisited: A biochemistry perspective
2013 • 138 citations
Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages
2017 • 138 citations
Hypothalamic regulation of energy homeostasis
2002 • 135 citations
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a “CB3” receptor
2003 • 133 citations
Type 1 Cannabinoid Receptor Ligands Display Functional Selectivity in a Cell Culture Model of Striatal Medium Spiny Projection Neurons
2014 • 128 citations
Leptin Deficiency Induced by Fasting Impairs the Satiety Response to Cholecystokinin**This work was supported by grants from the NIH (DK-12829, DK-52989, and NS-32272) and by the Royalty Research Fund, the Diabetes Endocrinology Research Center, and the Clinical Nutrition Research Unit of the University of Washington.
2000 • 128 citations
Critical role of the endogenous cannabinoid system in mouse pup suckling and growth
2001 • 126 citations
Eating when bored: Revision of the Emotional Eating Scale with a focus on boredom.
2011 • 126 citations
CART in the regulation of appetite and energy homeostasis
2014 • 124 citations
Mechanisms of Neuropeptide Y, Peptide YY, and Pancreatic Polypeptide Inhibition of Identified Green Fluorescent Protein-Expressing GABA Neurons in the Hypothalamic Neuroendocrine Arcuate Nucleus
2005 • 119 citations
Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice
2012 • 117 citations
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways
2009 • 116 citations
A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans
2011 • 111 citations
Advances in the Physiology of GPR55 in the Central Nervous System
2016 • 110 citations
Endocannabinoids and Food Intake: Newborn Suckling and Appetite Regulation in Adulthood
2005 • 107 citations
Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration
2016 • 107 citations
Multiple Roles for the Endocannabinoid System During the Earliest Stages of Life: Pre‐ and Postnatal Development
2008 • 107 citations
Chapter 15 Anandamide and the Vanilloid Receptor (TRPV1)
2009 • 106 citations
Cloning and Chromosomal Localization of a Gene (GPR18) Encoding a Novel Seven Transmembrane Receptor Highly Expressed in Spleen and Testis
1997 • 102 citations
Fatty Acid Modulation of the Endocannabinoid System and the Effect on Food Intake and Metabolism
2013 • 99 citations
Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: Predominant localization in pancreatic polypeptide-secreting PP-cells
2006 • 99 citations
Role of acylethanolamides in the gastrointestinal tract with special reference to food intake and energy balance
2009 • 96 citations
Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors
2006 • 92 citations
GPR3 and GPR6, novel molecular targets for cannabidiol
2017 • 87 citations
Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice
2015 • 83 citations
Evaluation of the insulin releasing and antihyperglycaemic activities of <scp>GPR55</scp> lipid agonists using clonal beta‐cells, isolated pancreatic islets and mice
2013 • 79 citations
GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment
2014 • 78 citations
The Phylogenetic Distribution and Evolutionary Origins of Endocannabinoid Signalling
2005 • 77 citations
Cyclamen graecum ekstraktlarının sıçan alt gastrointestinal sistem üzerindeki etkilerinin histokimyasal olarak araştırılması
2015 • 76 citations
Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding
2000 • 75 citations
N-arachidonoyl glycine induces macrophage apoptosis via GPR18
2012 • 74 citations
Cannabinoid-1 Receptor Antagonist, Rimonabant, for Management of Obesity and Related Risks
2006 • 73 citations
Actions of N-Arachidonyl-Glycine in a Rat Inflammatory Pain Model
2007 • 72 citations
Ethanol Exposure Induces Neonatal Neurodegeneration by Enhancing CB1R Exon1 Histone H4K8 Acetylation and Up-regulating CB1R Function causing Neurobehavioral Abnormalities in Adult Mice
2014 • 67 citations
GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine
2016 • 65 citations
In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569
2014 • 61 citations
Critical Role of the Endocannabinoid System in the Regulation of Food Intake and Energy Metabolism, with Phylogenetic, Developmental, and Pathophysiological Implications
2008 • 61 citations
Deletion of G-protein-coupled receptor 55 promotes obesity by reducing physical activity
2015 • 60 citations
Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons
2013 • 57 citations
Endogenous cannabinoid ligands — chemical and biological studies
1996 • 56 citations
A potential role for GPR55 in gastrointestinal functions
2012 • 56 citations
<scp>GPR55</scp>‐dependent stimulation of insulin secretion from isolated mouse and human islets of <scp>L</scp>angerhans
2016 • 54 citations
Reduced stomach capacity in obese subjects after dieting
1996 • 52 citations
Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity
2017 • 48 citations
CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis
2017 • 47 citations
The Leu34Phe ProCART Mutation Leads to Cocaine- and Amphetamine-Regulated Transcript (CART) Deficiency: A Possible Cause for Obesity in Humans
2005 • 47 citations
The Novel Endocannabinoid Receptor GPR18 Is Expressed in the Rostral Ventrolateral Medulla and Exerts Tonic Restraining Influence on Blood Pressure
2014 • 46 citations
The role of small molecule GPR119 agonist, AS1535907, in glucose-stimulated insulin secretion and pancreatic β-cell function
2010 • 45 citations
Linking Mitochondria and Synaptic Transmission: The CB1 Receptor
2017 • 44 citations
The atypical cannabinoid O‐1602 stimulates food intake and adiposity in rats
2011 • 44 citations
Dietary Influence on MAPK-Signaling Pathways and Risk of Colon and Rectal Cancer
2013 • 44 citations
Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice
2016 • 41 citations
Re-visiting the Endocannabinoid System and Its Therapeutic Potential in Obesity and Associated Diseases
2017 • 41 citations
Advances Towards The Discovery of GPR55 Ligands
2016 • 39 citations
Potential therapeutic applications of naturally occurring and synthetic cannabinoids
1978 • 37 citations
Role of the Endocannabinoid System in Depression: from Preclinical to Clinical Evidence
2015 • 37 citations
Time interval of oral feeding recovery as a prognostic factor in severe traumatic brain injury
2004 • 34 citations
Analysis of gene expression pattern reveals potential targets of dietary oleoylethanolamide in reducing body fat gain in C3H mice☆
2009 • 33 citations
G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction
2015 • 32 citations
Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues
2005 • 31 citations
Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation
2016 • 30 citations
Possible role of hippocampal GPR55 in spatial learning and memory in rats
2018 • 29 citations
Neuropeptide Y expression, localization and cellular transducing effects in HUVEC
2005 • 27 citations
Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors
2014 • 27 citations
Blockade of GPR55 in the dorsolateral striatum impairs performance of rats in a T-maze paradigm
2015 • 27 citations
β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation
2017 • 26 citations
Analysis of anandamide- and lysophosphatidylinositol-induced inhibition of the vasopressor responses produced by sympathetic stimulation or noradrenaline in pithed rats
2013 • 24 citations
The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice
2017 • 22 citations
GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation
2015 • 22 citations
Novel selective melanocortin 4 receptor antagonist induces food intake after peripheral administration
2003 • 22 citations
Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents
2008 • 21 citations
Inhibition of Milk Ingestion and Growth After Administration of a Neutral Cannabinoid CB1 Receptor Antagonist on the First Postnatal Day in the Mouse
2007 • 21 citations
LH‐21 and abnormal cannabidiol improve β‐cell function in isolated human and mouse islets through GPR55‐dependent and ‐independent signalling
2017 • 21 citations
Novel GPR119 agonist HD0471042 attenuated type 2 diabetes mellitus
2013 • 20 citations
PRESENT POSITION OF HEMP DRUG ADDICTION IN INDIA
1940 • 19 citations
Perspectives of CB1 Antagonist in Treatment of Obesity: Experience of RIO-Asia
2010 • 16 citations
Delta‐9‐tetrahydrocannabinol and gastric emptying.
1983 • 16 citations
Distinct recruitment of basolateral amygdala-medial prefrontal cortex pathways across Pavlovian appetitive conditioning
2017 • 16 citations
Mechanisms for AgRP neuron-mediated regulation of appetitive behaviors in rodents
2017 • 14 citations
mGluR1/5 activation in the lateral hypothalamus increases food intake via the endocannabinoid system
2016 • 13 citations
Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression
2015 • 13 citations