LH‐21 and abnormal cannabidiol improve β‐cell function in isolated human and mouse islets through GPR55‐dependent and ‐independent signalling

The orphan receptor GPR55 is a novel cannabinoid receptor

2007 • 1,487 citations

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

2008 • 658 citations

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

1999 • 599 citations

The Maintenance of Human Normal Cells and Tumor Cells in Continuous Culture: I. Preliminary Report: Cultivation of Mesoblastic Tumors and Normal Tissue and Notes on Methods of Cultivation

1936 • 598 citations

cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2

2003 • 541 citations

CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS

2005 • 480 citations

Identification of GPR55 as a lysophosphatidylinositol receptor

2007 • 428 citations

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

2016 • 401 citations

Cannabinoid CB2 receptor: a new target for controlling neural cell survival?

2006 • 350 citations

In silico patent searching reveals a new cannabinoid receptor

2005 • 339 citations

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

2009 • 312 citations

The GPR55 ligand L‐α‐lysophosphatidylinositol promotes RhoA‐dependent Ca²⁺signaling and NFAT activation

2008 • 278 citations

Atypical Responsiveness of the Orphan Receptor GPR55 to Cannabinoid Ligands

2009 • 266 citations

Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18

2006 • 252 citations

The diet‐derived short chain fatty acid propionate improves beta‐cell function in humans and stimulates insulin secretion from human islets in vitro

2016 • 226 citations

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation

2010 • 208 citations

Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy

2009 • 202 citations

GPR55 ligands promote receptor coupling to multiple signalling pathways

2010 • 195 citations

Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses

2013 • 193 citations

Presence of functional cannabinoid receptors in human endocrine pancreas

2007 • 187 citations

2-Arachidonoyl-sn-glycero-3-phosphoinositol: A Possible Natural Ligand for GPR55

2008 • 182 citations

Function and expression of melatonin receptors on human pancreatic islets

2008 • 177 citations

Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression

2008 • 174 citations

The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK

2010 • 171 citations

Protein phosphorylation in electrically permeabilized islets of Langerhans. Effects of Ca2+, cyclic AMP, a phorbol ester and noradrenaline

1988 • 154 citations

Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake

2006 • 146 citations

Activation of <scp>GPR</scp>18 by cannabinoid compounds: a tale of biased agonism

2014 • 143 citations

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells

2011 • 117 citations

Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats

2007 • 114 citations

Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole – LH 21

2006 • 114 citations

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans

2011 • 111 citations

Hashish. X. Simple one-step synthesis of (-)-.DELTA.1-tetrahydrocannabinol (THC) from p-mentha-2,8-dien-1-ol and olivetol

1974 • 110 citations

Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet β-cells via CB1 receptors

2007 • 105 citations

A new cannabinoid CB₂ receptor agonist HU‐910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury

2011 • 105 citations

The development of new density gradient media for purifying human islets and islet-quality assessments

2004 • 101 citations

Identification of the GPR55 Antagonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands

2013 • 97 citations

Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas

2010 • 92 citations

A Selective Antagonist Reveals a Potential Role of G Protein–Coupled Receptor 55 in Platelet and Endothelial Cell Function

2013 • 87 citations

Central Versus Peripheral Antagonism of Cannabinoid CB1 Receptor in Obesity: Effects of LH‐21, a Peripherally Acting Neutral Cannabinoid Receptor Antagonist, in Zucker Rats

2008 • 80 citations

Evaluation of the insulin releasing and antihyperglycaemic activities of <scp>GPR55</scp> lipid agonists using clonal beta‐cells, isolated pancreatic islets and mice

2013 • 79 citations

Kisspeptin stimulation of insulin secretion: mechanisms of action in mouse islets and rats

2009 • 75 citations

Identification of the GPR55 Agonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands

2011 • 68 citations

Discovery of 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a Novel in Vivo Cannabinoid Antagonist Containing a 1,2,4-Triazole Motif

2004 • 66 citations

Expression and function of cannabinoid receptors in mouse islets

2010 • 65 citations

GPR55: a new promising target for metabolism?

2017 • 56 citations

Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells

2010 • 56 citations

Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans

2011 • 56 citations

Anti‐obesity efficacy of LH‐21, a cannabinoid CB₁ receptor antagonist with poor brain penetration, in diet‐induced obese rats

2011 • 55 citations

Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice

2015 • 54 citations

<scp>GPR55</scp>‐dependent stimulation of insulin secretion from isolated mouse and human islets of <scp>L</scp>angerhans

2016 • 54 citations

The CB1 Antagonist Rimonabant Decreases Insulin Hypersecretion in Rat Pancreatic Islets

2009 • 49 citations

Metabolic effects of orally administered small-molecule agonists of GPR55 and GPR119 in multiple low-dose streptozotocin-induced diabetic and incretin-receptor-knockout mice

2016 • 41 citations

Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor

2008 • 41 citations

GPR55: From orphan to metabolic regulator?

2014 • 39 citations

The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice

2015 • 34 citations

G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction

2015 • 32 citations

Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues

2005 • 31 citations

Signaling through the p38 and p42/44 Mitogen-Activated Families of Protein Kinases in Pancreatic β-Cell Proliferation

2000 • 29 citations

The cytoprotective effects of oleoylethanolamide in insulin‐secreting cells do not require activation of GPR119

2011 • 26 citations

The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice

2017 • 22 citations

Nupr1 deletion protects against glucose intolerance by increasing beta cell mass

2013 • 20 citations

Chronic activation of cannabinoid receptors in vitro does not compromise mouse islet function

2012 • 19 citations

Reduced nuclear protein 1 expression improves insulin sensitivity and protects against diet-induced glucose intolerance through up-regulation of heat shock protein 70

2015 • 9 citations