Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity

The metabolic syndrome

2010 • 6,321 citations

The metabolic syndrome

2005 • 5,005 citations

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

2008 • 2,748 citations

Resolution of inflammation: the beginning programs the end

2005 • 2,353 citations

Obesity is associated with hypothalamic injury in rodents and humans

2011 • 1,582 citations

Resolvins

2002 • 1,575 citations

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

2008 • 1,261 citations

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

2005 • 1,099 citations

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

2009 • 1,031 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

2005 • 890 citations

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

2010 • 666 citations

Infection regulates pro-resolving mediators that lower antibiotic requirements

2012 • 592 citations

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

2010 • 538 citations

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

2013 • 476 citations

Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes

2006 • 432 citations

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

2009 • 404 citations

Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity

2012 • 352 citations

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

2015 • 341 citations

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

2010 • 322 citations

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

2013 • 280 citations

Resolution of inflammation is altered in Alzheimer's disease

2014 • 260 citations

TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation

2015 • 247 citations

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

2012 • 243 citations

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

2011 • 243 citations

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues.

1998 • 231 citations

Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci

2012 • 227 citations

Altered hypothalamic function in diet-induced obesity

2011 • 214 citations

Challenges and Opportunities of Defining Clinical Leptin Resistance

2012 • 212 citations

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

2012 • 211 citations

Resolvin D1 and Aspirin-Triggered Resolvin D1 Promote Resolution of Allergic Airways Responses

2012 • 211 citations

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

2013 • 202 citations

A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

2013 • 190 citations

Insulin modulates leptin‐induced STAT3 activation in rat hypothalamus

2001 • 167 citations

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

2012 • 164 citations

Could the Quality of Dietary Fat, and Not Just Its Quantity, Be Related to Risk of Obesity?

2008 • 144 citations

Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis

2009 • 143 citations

Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6

2013 • 127 citations

Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms

2006 • 102 citations

Freeze-dried jaboticaba peel powder improves insulin sensitivity in high-fat-fed mice

2013 • 84 citations

n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats

2014 • 82 citations

Hypothalamic Actions of Tumor Necrosis Factor α Provide the Thermogenic Core for the Wastage Syndrome in Cachexia

2009 • 81 citations

Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function

2011 • 77 citations

Defective Regulation of the Ubiquitin/Proteasome System in the Hypothalamus of Obese Male Mice

2014 • 66 citations

Saturated Fatty Acids Modulate Autophagy’s Proteins in the Hypothalamus

2015 • 63 citations

n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus

2015 • 56 citations

TLR4 Expression in Bone Marrow-Derived Cells Is Both Necessary and Sufficient to Produce the Insulin Resistance Phenotype in Diet-Induced Obesity

2014 • 36 citations

On the site and mechanism of action of the anti-obesity effects of interleukin-6

2003 • 34 citations

Central interleukin-10 attenuates lipopolysaccharide-induced changes in food intake, energy expenditure and hypothalamic Fos expression

2010 • 24 citations