Amyloid-β Deposition Is Associated with Decreased Hippocampal Glucose Metabolism and Spatial Memory Impairment in APP/PS1 Mice

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis

1988 • 2,948 citations

The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis

1988 • 2,498 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Remembrance of places passed: Spatial memory in rats.

1976 • 1,824 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1997 • 1,395 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Unbiased stereological estimation of the number of neurons in the human hippocampus

1990 • 1,146 citations

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

1999 • 1,118 citations

Functional Assessment Staging (FAST)

2001 • 1,027 citations

New stereological methods for counting neurons

1993 • 951 citations

Amphetamine, Haloperidol, and Experience Interact to Affect Rate of Recovery After Motor Cortex Injury

1982 • 916 citations

Positron Emission Tomography in Evaluation of Dementia

2001 • 882 citations

Selective vulnerability of the hippocampus in brain ischemia

1991 • 876 citations

Neural remodeling in retinal degeneration

2003 • 818 citations

Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

2002 • 764 citations

Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging

1999 • 745 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Prediction of cognitive decline in normal elderly subjects with 2-[ ¹⁸ F]fluoro-2-deoxy- <scp>d</scp> -glucose/positron-emission tomography (FDG/PET)

2001 • 619 citations

Hippocampal formation glucose metabolism and volume losses in MCI and AD

2001 • 555 citations

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1995 • 521 citations

Functional Assessment Staging (FAST) in Alzheimer's Disease: Reliability, Validity, and Ordinality

1992 • 521 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

1996 • 373 citations

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

1999 • 369 citations

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1999 • 355 citations

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

2001 • 346 citations

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

1996 • 301 citations

Comparative cytoarchitectonic atlas of the C57BL/6 and 129/Sv mouse brains

2000 • 287 citations

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

2003 • 276 citations

Remembrance of places passed: Spatial memory in rats.

1976 • 260 citations

Pro-Region of Neurotrophins

2003 • 251 citations

Energetics and Oxidative Stress in Synaptic Plasticity and Neurodegenerative Disorders

2002 • 240 citations

Age-Related Amyloid β Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid β Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss

2000 • 227 citations

Progressive and gender-dependent cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease

1999 • 221 citations

Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice

2001 • 199 citations

Reorganization of Cholinergic Terminals in the Cerebral Cortex and Hippocampus in Transgenic Mice Carrying Mutated Presenilin-1 and Amyloid Precursor Protein Transgenes

1999 • 196 citations

Amyloid Phenotype Characterization of Transgenic Mice Overexpressing both Mutant Amyloid Precursor Protein and Mutant Presenilin 1 Transgenes

1999 • 188 citations

Behavioral disturbances in transgenic mice overexpressing the V717F Β-amyloid precursor protein.

1999 • 185 citations

Behavioral disturbances in transgenic mice overexpressing the V717F Β-amyloid precursor protein.

1999 • 149 citations

Effects of enriched environments with different durations and starting times on learning capacity during aging in rats assessed by a refined procedure of the Hebb‐Williams maze task

2002 • 143 citations

The Alzheimer's Disease Activities of Daily Living International Scale (ADL-IS)

2001 • 139 citations

The CA1 Region of the Human Hippocampus Is a Hot Spot in Alzheimer's Disease

2000 • 124 citations

Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease

1998 • 123 citations

Hippocampus: Mapping or memory?

2000 • 121 citations

The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain

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The relationship of local cerebral glucose utilization to optical density ratios

1983 • 116 citations

Reactive Oxygen Species as Causal Agents in the Neurotoxicity of the Alzheimer's Disease‐Associated Amyloid Beta Peptidea

1996 • 116 citations

Spatial learning and memory, maze running strategies and cholinergic mechanisms in two inbred strains of mice

1985 • 114 citations

Hippocampal Aβ42 Levels Correlate with Spatial Memory Deficit in APP and PS1 Double Transgenic Mice

2002 • 114 citations

Overexpression of Wild Type But Not an FAD Mutant Presenilin-1 Promotes Neurogenesis in the Hippocampus of Adult Mice

2002 • 112 citations

Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human β-amyloid precursor protein

2002 • 112 citations

Transgenic mouse brain histopathology resembles early Alzheimer's disease

1994 • 110 citations

Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine

2002 • 105 citations

Quantitative histological analysis of amyloid deposition in Alzheimer’s double transgenic mouse brain

2000 • 103 citations

Protofibrils of amyloid β-protein inhibit specific K+ currents in neocortical cultures

2003 • 77 citations

Motor/Psychomotor Dysfunction in Normal Aging, Mild Cognitive Decline, and Early Alzheimer's Disease: Diagnostic and Differential Diagnostic Features

1997 • 76 citations

Amyloid β Toxicity Consists of a Ca²⁺‐Independent Early Phase and a Ca²⁺‐Dependent Late Phase

1996 • 73 citations

Global increase in cerebral metabolism and blood flow produced by focal electrical stimulation of dorsal medullary reticular formation in rat

1983 • 73 citations

Diffuse, Lake-like Amyloid-β Deposits in the Parvopyramidal Layer of the Presubiculum in Alzheimer Disease

1998 • 68 citations

The effect of chronic treatment with typical and atypical antipsychotics on working memory and jaw movements in three- and eighteen-month-old rats

2002 • 61 citations

Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate Alzheimer plaque pathology

2003 • 50 citations

Pattern of neuronal loss in the rat hippocampus following experimental cardiac arrest-induced ischemia

1999 • 48 citations

Selective Antibody-Induced Cholinergic Cell and Synapse Loss Produce Sustained Hippocampal and Cortical Hypometabolism with Correlated Cognitive Deficits

2001 • 47 citations

Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism

1994 • 44 citations

In defence of optical density ratios in 2-deoxyglucose autoradiography

1984 • 36 citations

Clinical and Neuropathological Correlates of Apolipoprotein E Genotype in Alzheimer's Disease ‐ Window on Molecular Epidemiologya

1996 • 31 citations

Functional Activation of Cerebral Metabolism in Mice with Mutated Thyroid Hormone Nuclear Receptors

2003 • 30 citations

Effects of Neocortical Ectopias and Environmental Enrichment on Hebb-Williams Maze Learning in BXSB Mice

2001 • 22 citations

Cell-Type-Specific Enhancement of Amyloid-β Deposition in a Novel Presenilin-1 Mutation (P117L)

1998 • 22 citations

Stress-induced subsensitivity to modafinil and its prevention by corticosteroids

2002 • 17 citations

Detection of Object Orientation and Spatial Changes by Mice: Importance of Local Views

1998 • 13 citations

Behavioral effects of arginine8-vasopressin in the Hebb–Williams maze

2003 • 12 citations

Proceedings of the Physiological Society, 26‐27 March 1984, University College Meeting: Poster Communications

1984 • 2 citations

16 Clinical course and the neglected half of Alzheimer's disease (AD)

1996 • 1 citations

Neuronal loss in the hippocampus of individuals in early and advanced stages of Alzheimer's disease

2002 • 1 citations

β-APP751 transgenic mice exhibit impaired learning

1994 • 1 citations