Chemical carcinogens a review and analysis of the literature of selected chemicals and the establishment of the Gene-Tox carcinogen data base

Carcinogenicity of Butylated Hydroxyanisole in F344 Rats<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref><xref ref-type="fn" rid="fn4">4</xref>

1983 • 574 citations

Sister-chromatid exchanges: A report of the GENE-TOX program

1981 • 557 citations

Bioassay of Pesticides and Industrial Chemicals for Tumorigenicity in Mice: A Preliminary Note<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 523 citations

A carcinogenic potency database of the standardized results of animal bioassays

1984 • 471 citations

Neoplastic and nonneoplastic lesions in aging F344 rats

1979 • 470 citations

Chromosome aberration assays in allium

1982 • 422 citations

An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals

1983 • 411 citations

Cocarcinogenic and Tumor-Promoting Agents in Tobacco Carcinogenesis2

1976 • 344 citations

Induction and Extinction of Mammary Cancer

1962 • 331 citations

Use of Historical Control Data in Carcinogenicity Studies in Rodents

1984 • 319 citations

Mutagenesis by chemical agents in V79 Chinese hamster cells: A review and analysis of the literature

1981 • 297 citations

Mammalian in vivo and in vitro cytogenetic assays

1981 • 287 citations

The Salmonella typhimurium/mammalian microsomal assay

1986 • 286 citations

Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.

1978 • 239 citations

Cell transformation by chemical agents — A review and analysis of the literature

1983 • 224 citations

Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats

1984 • 212 citations

Carcinogenicity of epoxides, lactones, and peroxy compounds. II.

1965 • 211 citations

The TD50: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments.

1984 • 211 citations

THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.

1964 • 202 citations

Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.

1967 • 202 citations

Colon carcinogenesis with azoxymethane and dimethylhydrazine in germ-free rats.

1975 • 188 citations

An evaluation of human sperm as indicators of chemically induced alterations of spermatogenic function

1983 • 184 citations

An Experimental Study of the Initiating Stage of Carcinogenesis, and a Re-examination of the Somatic Cell Mutation Theory of Cancer

1949 • 176 citations

Promotion of azoxymethane-induced intestinal cancer by high-fat diet in rats.

1979 • 164 citations

The sex-linked recessive lethal test for mutagenesis in Drosophila melanogaster

1983 • 160 citations

Effect of Dietary Alfalfa, Pectin, and Wheat Bran on Azoxymethane- or Methylnitrosourea-Induced Colon Carcinogenesis in F344 Rats<xref ref-type="fn" rid="fn2">2</xref>

1979 • 153 citations

Carcinogenic Activity of Alkylating Agents2

1974 • 152 citations

A comparison of ultrastructural changes in rat liver due to chemical carcinogens.

1968 • 151 citations

Molecular and Cellular Aspects of Carcinogen Screening Tests

1981 • 150 citations

1'-Hydroxysafrole, a proximate carcinogenic metabolite of safrole in the rat and mouse.

1973 • 146 citations

A two-year inhalation study of the carcinogenic potential of ethylene oxide in fischer 344 rats*1

1984 • 145 citations

Experimental Studies in Rat Lungs on the Carcinogenicity and Dose-Response Relationships of Eight Frequently Occurring Environmental Polycyclic Aromatic Hydrocarbons<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 144 citations

Specific induction of bladder cancer in mice by butyl-(4-hydroxybutyl)-nitrosamine and the effects of hormonal modifications on the sex difference in response

1972 • 143 citations

The tumorigenicity of 5-azacytidine in the male Fischer rat

1984 • 143 citations

Benzene: A multipotential carcinogen. Results of long‐term bioassays performed at the bologna institute of oncology

1983 • 142 citations

Carcinogenicity of Halogenated Olefinic and Aliphatic Hydrocarbons in Mice<xref ref-type="fn" rid="FN2">2</xref>

1979 • 142 citations

The mouse specific-locus test with agents other than radiations

1981 • 141 citations

The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals

1981 • 141 citations

On the Carcinogenicity of an Iron-Dextran Complex<xref ref-type="fn" rid="FN1">2</xref>

1960 • 136 citations

The carcinogenicity of compounds related to 2-acetylaminofluorene. II. Variations in the bridges and the 2-substituent.

1955 • 135 citations

Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U.S. environmental protection agency gene-tox program

1984 • 134 citations

Test for carcinogenicity of metallic compounds by the pulmonary tumor response in strain A mice.

1976 • 132 citations

Chrysene and Methylchrysenes: Presence in Tobacco Smoke and Carcinogenicity23

1974 • 123 citations

Benzene inhalation produces leukemia in mice

1984 • 122 citations

Carcinogenicity study of trichloroethylene by longterm inhalation in three animal species

1980 • 121 citations

Heritable translocation test in mice

1980 • 120 citations

Histopathologic Studies on Liver Tumorigenesis Induced in Mice by Technical Polychlorinated Biphenyls and Its Promoting Effect on Liver Tumors Induced by Benzene Hexachloride 2

1973 • 119 citations

Unscheduled DNA synthesis tests

1983 • 119 citations

Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.

1977 • 118 citations

Further Studies on Incomplete Carcinogenesis: Triethylene Melamine (T.E.M.), 1,2-Benzanthracene and β-Propiolactone, as Initiators of Skin Tumour Formation in the Mouse

1955 • 118 citations

Carcinogenicity of ethylene oxide and 1,2-propylene oxide upon intragastric administration to rats

1982 • 118 citations

Vicia cytogenetic tests for environmental mutagens

1982 • 117 citations

PROTOPORPHYRIN, CIRRHOSIS AND HEPATOMATA IN THE LIVERS OF MICE GIVEN GRISEOFULVIN.

1963 • 116 citations

A study of tobacco carcinogenesis.VII. The role of higher polycyclic hydrocarbons

1959 • 116 citations

Carcinogenicity of 5-nitrofurans, 5-nitroimidazoles, 4-nitrobenzenes, and related compounds.

1973 • 113 citations

Factors in the evaluation of 200 national cancer institute carcinogen bioassays

1981 • 112 citations

Inhalation carcinogenicity of trichloroethylene in mice and rats.

1983 • 112 citations

The carcinogenicity of multiple intragastric doses of aromatic and heterocyclic nitro or amino derivatives in young female sprague-dawley rats.

1968 • 111 citations

Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol

1976 • 110 citations

Nitrosamine Studies: Induction of Lung Adenomas by Concurrent Administration of Sodium Nitrite and Secondary Amines in Swiss Mice<xref ref-type="fn" rid="FN2">2</xref>

1971 • 110 citations

Chemicals showing no evidence of carcinogenicity in long‐term, two‐species rodent studies: The need for short‐term test data

1984 • 109 citations

The carcinogenic activity of some 5-nitrofuran derivatives in the rat.

1969 • 107 citations

An evaluation of the Escherichia coli WP2 and WP2uvrA reverse mutation assay

1980 • 107 citations

Carcnogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic activity.

1967 • 106 citations

Bioassay program for carcinogenic hazards of cancer chemotherapeutic agents

1977 • 103 citations

Comparison of two-stage epidermal carcinogenesis initiated by 7,12-dimethylbenz(a)anthracene or N-methyl-N'-nitro-N-nitrosoguanidine in newborn and adult SENCAR and BALB/c mice.

1981 • 103 citations

Chemical Carcinogenesis in Nude Mice: Comparison Between Nude Mice From Homozygous Matings and Heterozygous Matings and Effect of Age and Carcinogen Dose<xref ref-type="fn" rid="fn2">2</xref>

1979 • 103 citations

Current status of bioassays in genetic toxicology — The dominant lethal assay

1985 • 102 citations

Pulmonary Tumours in Mice induced by Oral Isoniazid and its Metabolites

1962 • 98 citations

N-Benzoyloxy-N-methyl-4-aminoazobenzene: its carcinogenic activity in the rat and its reactions with proteins and nucleic acids and their constituents in vitro.

1967 • 98 citations

The Induction of Tumours of the Subcutaneous Tissues, Liver and Intestine in the Mouse by Certain Dyestuffs and their Intermediates

1956 • 97 citations

Marked differences in the tumor-initiating activity of optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene on mouse skin.

1977 • 95 citations

Evidence that benzo(a)anthracene 3,4-diol-1,2-epoxide is an ultimate carcinogen on mouse skin.

1978 • 94 citations

Incomplete Carcinogens: Ethyl Carbamate (Urethane) as an Initiator of Skin Tumour Formation in the Mouse

1953 • 94 citations

Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin.

1979 • 93 citations

Inhibitory effect of 13-cis-retinoic acid on urinary bladder carcinogenesis induced in C57BL/6 mice by N-butyl-N-(4-hydroxybutyl)-nitrosamine.

1978 • 93 citations

Long-term testing of patulin administered orally to sprague-dawley rats and swiss mice

1976 • 92 citations

Organic Peroxides, Hydrogen Peroxide, Epoxides, and Neoplasia

1963 • 92 citations

Effect of dietary undegraded carrageenan on colon carcinogenesis in F344 rats treated with azoxymethane or methylnitrosourea.

1978 • 92 citations

The Relation between Carcinogenic Activity and the Physical and Chemical Properties of Angular Benzacridines

1956 • 91 citations

Comparative tumor initiating activity on mouse skin of 6-nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and their parent hydrocarbons

1982 • 91 citations

An evaluation of tests using DNA repair-deficient bacteria for predicting genotoxicity and carcinogenicity

1981 • 90 citations

A report of the U.S. environmental protection agency gene-tox program

1982 • 88 citations

The role of aryl hydrocarbon hydroxylase in 7,12-dimethylbenz(a)anthracene skin tumorigenesis: on the mechanism of 7,8-benzoflavone inhibition of tumorigenesis.

1972 • 87 citations

An enantiomeric interaction in the metabolism and tumorigenicity of (+)- and (-)-benzo[a]pyrene 7,8-oxide.

1980 • 86 citations

Carcinogenicity of chloroethylene oxide, an ultimate reactive metabolite of vinyl chloride, and bis(chloromethyl)ether after subcutaneous administration and in initiation-promotion experiments in mice.

1980 • 86 citations

Comparative carcinogenicities and mutagenicities of vinyl carbamate, ethyl carbamate, and ethyl N-hydroxycarbamate.

1980 • 86 citations

Use of the mouse spot test in chemical mutagenesis: Interpretation of past data and recommendations for future work

1981 • 85 citations

Specific gene mutations in L5178Y cells in culture

1983 • 84 citations

Comparison of the tumor-initiating activities of benzo(a)pyrene arene oxides and diol-epoxides.

1977 • 83 citations

Tumor Initiation by Apparently Noncarcinogenic Polycyclic Aromatic Hydrocarbons2

1973 • 81 citations

Carcinogenicity tests of certain environmental and industrial chemicals.

1981 • 81 citations

Carcinogenicity of methylated nitrosopiperidines

1975 • 81 citations

Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds. IV. Tumor Response in Epithelial and Connective Tissue in Mice and Rats<xref ref-type="fn" rid="FN2">2</xref>

1966 • 79 citations

Survey of compounds which have been tested for carcinogenic activity

1992 • 79 citations

Introduction and perspectives of plant genetic and cytogenetic assays a report of the U.S. environmental protection agency Gene-Tox program

1982 • 78 citations

SUGAR ALCOHOLS

1941 • 78 citations

The Carcinogenicity of Certain Azo Dyes Related to p-Dimethylaminoazobenzene

1945 • 77 citations

The carcinogenic activities in mice of compounds related to benz[a]anthracene

1967 • 77 citations

Promotion of mouse liver neoplasms by the organochlorine pesticides chlordane and heptachlor in comparison to dichlorodiphenyltrichlorpethane

1984 • 77 citations

N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in C57BL/6 X DBA/2 F1 mice as a useful model for study of chemoprevention of cancer with retinoids.

1981 • 75 citations

Carcinogenicity of derivatives of 7,12-dimethylbenz(a)anthracene.

1971 • 75 citations

Further Tests for Tumour-Initiating Activity: N,N-DI-(2-Chloroethyl)-P-Aminophenylbutyric Acid (CB1348) as an Initiator of Skin Tumour Formation in the Mouse

1956 • 74 citations

The GENE-TOX Program: genetic activity evaluation

1981 • 73 citations

CARCINOGENESIS AND INHIBITION OF THE WALKER 256 TUMOR IN THE RAT BY TRANS-4-ACETYLAMINOSTILBENE, ITS N-HYDROXY METABOLITE, AND RELATED COMPOUNDS.

1964 • 73 citations

Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene

1976 • 71 citations

Carcinogene Wirkung von 13 Aryldialkyltriazenen an BD-Ratten

1974 • 71 citations

Carcinogenicity of benzo-ring derivatives of benzo(a)pyrene on mouse skin.

1977 • 71 citations

Summation and inhibition effects of weak and strong carcinogenic hydrocarbons: 1:2-benzanthracene, chrysene, 1:2:5:6-dibenzanthracene, and 20-methylcholanthrene.

1951 • 70 citations

Hydrazine, methylhydrazine and methylhydrazine sulfate carcinogenesis in swiss mice. failure of ammonium hydroxide to interfere in the development of tumors

1972 • 70 citations

Effect of Dietary Wheat Bran and Dehydrated Citrus Fiber on Azoxymethane-Induced Intestinal Carcinogenesis in Fischer 344 Rats<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 70 citations

Neurotrope carcinogene Wirkung von Phenyl-dimethyl-triazen an Ratten

1967 • 70 citations

Long‐term carcinogenicity and toxicity studies of patulin in the rat

1981 • 69 citations

Hepatic Tumors Due to Prolonged Ethionine Feeding

1953 • 68 citations

Mutagenicity and tumorigenicity of phenanthrene and chrysene epoxides and diol epoxides.

1979 • 68 citations

Carcinogenicity and mutagenicity of benz(a)anthracene diols and diol-epoxides.

1978 • 67 citations

Structure and activity in chemical carcinogenesis

1970 • 67 citations

Studies of the carcinogenic action in the rat of 2-nitro, 2-amino-, 2-acetylamino-, and 2-diacetylaminofluorene after ingestion and after painting.

1950 • 67 citations

ENZYMATIC HISTOCHEMISTRY OF ETHIONINE INDUCED LIVER CIRRHOSIS AND HEPATOMA

1959 • 66 citations

Skin initiating action and lung carcinogenesis by derivatives of urethane (ethyl carbamate) and related compounds

1959 • 65 citations

Tradescantia cytogenetic tests (root-tip mitosis, pollen mitosis, pollen mother-cell meiosis)

1982 • 65 citations

The effects of weak or non-carcinogenic polycyclic hydrocarbons on 7, 12-dimethylbenz[a]anthracene and benzo[a]pyrene skin tumor-initiation

1979 • 65 citations

Carcinogenicity and mutagenicity of the 3,4-dihydrodiols and other metabolites of 7,12-dimethylbenz(a)anthracene and its hydroxymethyl derivatives.

1980 • 65 citations

In vitro and in vivo indications of the carcinogenicity and toxicity of food dyes

1978 • 64 citations

Effect of Dietary Fiber on Azoxymethane-Induced Intestinal Carcinogenesis in Rats<xref ref-type="fn" rid="FN2">2</xref>

1979 • 64 citations

A Preliminary Study Concerning the Possibility of Dietary Carcinogenesis

1953 • 64 citations

Mutagenicity, tumor-initiating activity, and metabolism of methylphenanthrenes.

1981 • 64 citations

Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel.

1978 • 63 citations

The Tumor-Promoting Agents of Tobacco Leaf and Tobacco Smoke Condensate<xref ref-type="fn" rid="FN2">2</xref>

1966 • 62 citations

The inhibitory effect of copper on DL-ethionine carcinogenesis in rats.

1973 • 62 citations

Mutagenicity and tumor-initiating activity of cyclopenta(c,d)pyrene and structurally related compounds.

1980 • 61 citations

The covalent binding of metabolites of tritiated 2-methyl-4-dimethylaminoazobenzene to rat liver nucleic acids and proteins, and the carcinogenicity of the unlabelled compound in partially hepatectomised rats

1967 • 61 citations

Hepatic carcinogenesis in CBA-Cb-Se mice and Cb-Se rats by isonicotinic acid hydrazide and hydrazine sulfate.

1968 • 60 citations

Carcinogenicity testing of N-hydroxy and other oxidation and decomposition products of 1- and 2-naphthylamine.

1971 • 60 citations

Hyperbasophilic foci as sites of neoplastic transformation in hepatic parenchyma.

1971 • 59 citations

Evidence for bay region activation of chrysene 1,2-dihydrodiol to an ultimate carcinogen.

1978 • 59 citations

Bioassay of alkyl halides and nucleotide base analogs by pulmonary tumor response in strain A mice.

1975 • 59 citations

On the correlation between the hepatocarcinogenicity of the carcinogen, N-2-fluorenylacetamide, and its metabolic activation by the rat.

1972 • 59 citations

Marked differences in the carcinogenic activity of optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in newborn mice.

1978 • 59 citations

On the oncogenic activity of ethylene oxide and propylene oxide in mice

1979 • 58 citations

Carcinogenicity study of trichloroethylene, with and without epoxide stabilizer, in mice

1984 • 57 citations

Enhancement of the Antitumor Effect of 1,3-Bis(2-Chloroethyl)- 1-Nitrosourea by Chlorpromazine and Caffeine2

1973 • 57 citations

Comparison of the skin tumor-initiating activities of dihydrodiols and diol-epoxides of various polycyclic aromatic hydrocarbons.

1980 • 56 citations

Enhancement of DL-Ethionine-Induced Liver Carcinogenesis in Rats Fed a Choline-Devoid Diet<xref ref-type="fn" rid="FN2">2</xref>

1978 • 56 citations

Gastro-intestinal tumours in rats and mice following various routes of administration of N-methyl-N-nitroso-N'-nitroguanidine and N-ethyl-N-nitroso-N'-nitroguanidine.

1969 • 56 citations

The carcinogenic activities in mice of compounds related to 3‐methylcholanthrene

1967 • 56 citations

Influence of ethyl alcohol on carcinogenesis with N-nitrosodimethylamine

1981 • 55 citations

Two-stage tumorigenesis of dermal melanocytes in the back skin of the Syrian golden hamster using systemic initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-O-tetradecanoylphorbol-13-acetate.

1980 • 55 citations

Tumorigenesis studies with 1,2-dimethylhydrazine dihydrochloride, hydrazine sulfate, and isonicotinic acid in golden hamsters.

1972 • 55 citations

The metabolic activation of 7-methylbenz(a)anthracene in mouse skin: High tumour-initiating activity of the 3,4-dihydrodiol

1977 • 55 citations

Studies of skin carcinogenesis in the Syrian golden hamster.

1960 • 53 citations

Tumors in Control Hamsters, Rats, and Mice: Literature Tabulation

1982 • 53 citations

Tradescantia assay system for gaseous mutagens

1982 • 52 citations

Methylhydrazine tumorigenesis in Syrian golden hamsters and the morphology of malignant histiocytomas.

1973 • 52 citations

Inherited susceptibility of inbred strains of Syrian hamsters to induction of subcutaneous sarcomas and mammary and gastrointestinal carcinomas by subcutaneous and gastric administration of polynuclear hydrocarbons.

1972 • 52 citations

Studies on hepatic protein-bound dye formation in rats given single large doses of 3'methyl-4-dimethylaminoazobenzene.

1958 • 52 citations

Tumorigenicity of enantiomers of chrysene 1,2-dihydrodiol and of the diastereomeric bay-region chrysene 1,2-diol-3,4-epoxides on mouse skin and in newborn mice.

1983 • 51 citations

Carcinogenicity of the food additive furylfuramide in foetal and young mice

1975 • 51 citations

High carcinogenicity of 2-hydroxybenzo(a)pyrene on mouse skin.

1977 • 51 citations

Early appearance of serum -fetoprotein during hepatocarcinogenesis as a function of age of rats and extent of treatment with 3'-methyl-4-dimethylaminoazobenzene.

1972 • 51 citations

Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates

1983 • 50 citations

Data on the carcinogenicity of chemicals in the IARC Monographs programme

1985 • 50 citations

Lack of carcinogenicity of 4-, 5-, 6-, 7-, 8-, 9-, and 10-hydroxybenzo(a)pyrene on mouse skin.

1976 • 50 citations

Macromolecular synthesis following a single application of alkylating agents used as initiators of mouse skin tumorigenesis.

1973 • 50 citations

Urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in dogs.

1981 • 50 citations

Chromosome mutation tests for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program.

1984 • 48 citations

Chromosome aberration assays in barley (Hordeum vulgare) a report of the U.S. environmental protection agency Gene-Tox program

1982 • 48 citations

Enhanced colonic carcinogenesis with azoxymethane in rats after pancreaticobiliary diversion to mid small bowel

1979 • 47 citations

The prevention of ethionine-induced carcinoma of the liver in rats by methionine.

1958 • 47 citations

Cocarcinogenesis Studies on Mouse Skin and Inhibition of Tumor Induction<xref ref-type="fn" rid="FN2">2</xref>

1971 • 47 citations

4-aminoazobenzene and N,N-dimethyl-4-aminoazobenzene as equipotent hepatic carcinogens in male C57BL/6 X C3H/He F1 mice and characterization of N-(Deoxyguanosin-8-yl)-4-aminoazobenzene as the major persistent hepatic DNA-bound dye in these mice.

1984 • 46 citations

Metabolism of trans-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene occurs primarily by arylhydroxylation rather than formation of a diol epoxide.

1978 • 46 citations

Comparative tumor-initiating activity of methylated benzo(a)pyrene derivatives in mouse skin.

1980 • 46 citations

On the carcinogenicity of a single intragastric dose of hydrocarbons, nitrosamines, aromatic amines, dyes, coumarins, and miscellaneous chemicals in female Sprague-Dawley rats.

1966 • 45 citations

Exceptional carcinogenic activity of benz[a]anthracene 3,4-dihydrodiol in the newborn mouse and the bay region theory.

1978 • 44 citations

Follow‐up study on the carcinogenicity of vinyl chloride and vinylidene chloride in rats and mice: Tumor incidence and mortality subsequent to exposure

1981 • 44 citations

PIGMENTATION AND HAIR GROWTH IN BLACK RATS, AS MODIFIED BY THE CHRONIC ADMINISTRATION OF THIOUREA, PHENYL THIOUREA AND ALPHA-NAPHTHYL THIOUREA1

1947 • 44 citations

Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on azoxymethane-induced intestinal carcinogenesis.

1980 • 44 citations

Tumorigenicity of bay-region epoxides and other derivatives of chrysene and phenanthrene in newborn mice.

1979 • 43 citations

The carcinogenicity of polycyclic hydrocarbon epoxides in newborn mice

1975 • 43 citations

Studies in Carcinogenesis. XVI. Production of Subcutaneous Tumors in Mice by Miscellaneous Polycyclic Compounds<xref ref-type="fn" rid="fn1">1</xref>

1941 • 43 citations

Molecular site of substituents of benz(a)anthracene related to carcinogenicity.

1969 • 43 citations

Mutation tests in Neurospora crassa

1984 • 43 citations

Comparative electrophilicity, mutagenicity, DNA repair induction activity, and carcinogenicity of some N- and O-acyl derivatives of N-hydroxy-2-aminoflourene.

1977 • 42 citations

A comparison of the oncogenicities of 3-hydroxyxanthine, guanine 3-N-oxide, and some related compounds.

1970 • 42 citations

Alcohol and hamster buccal pouch carcinogenesis

1978 • 42 citations

Skin tumor-initiating activities of the twelve isomeric phenols of benzo(a)pyrene.

1978 • 42 citations

Tumorigenicity of five cyclic nitrosamines in MRC rats

1972 • 42 citations

Tumour initiating activity of dihydrodiols of benzo[b]fluoranthene, benzo[j]fluoranthene, and benzo[k]fluoranthene

1982 • 42 citations

Inhibiting effect of caffeine on spontaneous and urethan-induced lung tumors in strain A mice.

1978 • 42 citations

Neoplastic Effects of Oral Administration of (±)-<italic>trans</italic>-7 ,8-Dihydroxy-7,8-dihydrobenzo[<italic>a</italic>]pyrene and Their Inhibition by Butylated Hydroxyanisole<xref ref-type="fn" rid="FN2">2</xref>

1979 • 41 citations

N-hydroxy metabolites of 2-acetylaminophenanthrene and 7-fluoro-2-acetylaminofluorene as proximate carcinogens in the rat.

1966 • 41 citations

Myelogenous leukemia in rodents inhaling benzene

1982 • 41 citations

Chromosome mutation tests for mutagenesis in Drosophila melanogaster

1984 • 41 citations

Production of Urinary Bladder Carcinomas in Male Hamsters by N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide, N-[4-(5-Nitro-2-furyl)-2-thiazolyl]-acetamide, or Formic Acid 2-[4-(5-Nitro-2-furyl)-2-thiazolyi]hydrazide2

1973 • 41 citations

Genetically determined susceptibility of Fischer 344 rats to propylnitrosourea-induced thymic lymphomas.

1985 • 40 citations

Skin melanoma induced by 7,12-dimethylbenzanthracene in albino guinea pigs and its similarities to skin melanoma of humans.

1980 • 40 citations

The Origin of Experimental Basal Cell Epitheliomas in the Rat

1962 • 40 citations

Inhalation Carcinogenicity of Alpha Halo Ethers

1975 • 40 citations

Chronic toxicity studies of vinyl acetate in Fischer rats

1983 • 39 citations

Influence of alpha-naphthyl-isothiocyanate on liver tumorigenesis in rats ingesting ethionine and N-2-fluorenylacetamide.

1966 • 39 citations

A carcinogenicity study of styrene-7,8-oxide in rats

1984 • 39 citations

Induction of Hepatomas in CBA/Cb/Se Mice by Hydrazine Sulphate and the Lack of Effect of Croton Oil on Tumour Induction in BALB/c/Cb/Se Mice

1964 • 38 citations

Inhibition of carcinogenic effect of bracken fern (pteridium aquilinum) by various chemicals

1977 • 38 citations

Comparative carcinogenicity in Swiss mice of N-(4-(5-nitro-2-furyl)-2-thiazolyl)acetamide and structurally related 5-nitrofurans and 4-nitrobenzenes.

1973 • 38 citations

Carcinogenicity and metabolic profiles of 6-substituted benzo[a]pyrene derivatives on mouse skin

1978 • 38 citations

Cocarcinogenic Versus Incomplete Carcinogenic Activity Among Aromatic Hydrocarbons: Contrast Between Chrysene and Benzo[bltriphenylene2

1974 • 38 citations

Pulmonary Tumors in Strain A Mice Given Injections of Aflatoxin B1<xref ref-type="fn" rid="FN2">2</xref>

1968 • 38 citations

Skin-tumor-initiating ability of benzo(a)pyrene-7,8-diol-9,10-epoxide (anti) when applied topically in tetrahydrofuran

1977 • 38 citations

Inhibition of urinary bladder cancer by N-(ethyl)-all-trans-retinamide and N-(2-hydroxyethyl)-all-trans-retinamide in rats and mice.

1981 • 37 citations

Lifetime carcinogenicity study of 1- and 2-naphthylamine in dogs

1981 • 37 citations

Specific-locus mutation assay in Zea may

1982 • 37 citations

The Carcinogenicities of Derivatives of Fluorene and Biphenyl: Fluoro Derivatives as Probes for Active Sites in 2-Acetylaminofluorene

1962 • 37 citations

Carcinogenicity of the environmental pollutants cyclopenteno-(cd) pyrene and cyclopentano(cd)pyrene in mouse skin

1981 • 36 citations

Lung tumor response in strain A mice as a quantitative bioassay of carcinogenic activity of some carbamates and aziridines.

1969 • 36 citations

Carcinogenicity of Methylated Dinitrosopiperazines in Rats

1975 • 36 citations

Soybean (Glycine max [L.] merrill) as a short-term assay for study of environmental mutagen

1982 • 36 citations

II. Haploid assay systems and overall response of all systems A report of the U.S. EPA gene-tox program

1982 • 36 citations

Experimentelle Untersuchungen zur Syncarcinogenese

1965 • 36 citations

Carcinogenicity and toxicity of malathion and malaoxon

1985 • 36 citations

The importance of the “bay region” diol-epoxide in 7,12-dimethylbenz[a]anthracene skin tumor initiation and mutagenesis

1979 • 35 citations

Skin Tumors in Mice Painted With <italic>N</italic>-Methyl-<italic>N</italic>′-Nitro-<italic>N</italic>-Nitrosoguanidine and <italic>N</italic>-Ethyl-<italic>N</italic>′-Nitro-<italic>N</italic>-Nitrosoguanidine<xref ref-type="fn" rid="FN2">2</xref>

1971 • 35 citations

DNA repair assays as tests for environmental mutagens

1982 • 35 citations

Relative Carcinogenic Activity of Monomethyl Derivatives of Benz[<italic>a</italic>]anthracene in Fischer Line 344 Rats<xref ref-type="fn" rid="FN1">2</xref>

1960 • 34 citations

Carcinogenicity of Isosters of Epoxides and Lactones: Aziridine Ethanol, Propane Sultone, and Related Compounds<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1971 • 34 citations

Structure and activity in chemical carcinogenesis

1971 • 34 citations

Alcoholism and cancer. I. Effects of long-term exposure to alcohol on spontaneous mammary adenocarcinoma and prolactin levels in C3H/St mice.

1979 • 34 citations

Thyroid tumours in rats and hepatomas in mice after griseofulvin treatment

1978 • 34 citations

THE EFFECT OF DIETARY COPPER ON RAT CARCINOGENESIS BY 3-METHOXY DYES. I. TUMORS INDUCED AT VARIOUS SITES BY FEEDING 3-METHOXY-4-AMINOAZOBENZENE AND ITS N-METHYL DERIVATIVE.

1964 • 33 citations

Synthesis and carcinogenicity of compounds related to 6-hydroxymethylbenzo[a]pyrene

1973 • 32 citations

Structure-Activity Relationships Among Some Polynuclear Hydrocarbons and Their Hydrogenated Derivatives<xref ref-type="fn" rid="FN2">2</xref>

1970 • 32 citations

Influence of total dose and dose schedule on induction of urinary bladder cancer in the mouse by N-butyl-N-(4-hydroxy-butyl)nitrosamine

1981 • 32 citations

Initiating Activity of Aromatic Hydrocarbons in Two-Stage Carcinogenesis<xref ref-type="fn" rid="FN2">2</xref>

1970 • 32 citations

EXPERIMENTAL STUDIES ON TUMORS OF THE URINARY SYSTEM OF RATS INDUCED BY CHEMICAL CARCINOGENS*

1973 • 31 citations

Experimentally induced cancer of the colon in rats and mice.

1974 • 31 citations

A chronic toxicity and oncogenicity study in rats and subchronic toxicity study in dogs on ingested vinylidene chloride

1983 • 31 citations

Carcinogens from fungi pathogenic for man.

1968 • 30 citations

Tumors of the Liver and Urinary Bladder of the Dog After Ingestion of 2-Acetylaminofluorene

1953 • 30 citations

Pulmonary carcinogenesis by derivatives of polynuclear aromatic alkylating agents.

1976 • 30 citations

The Induction of Tumours in Mice by Intravaginal Application of Chemical Compounds

1961 • 30 citations

Tumorigenic activity of 3-methylcholanthrene metabolites on mouse skin and in newborn mice.

1979 • 30 citations

Carcinogenic Activity of Metabolic Products of 3:4-Benzpyrene: Application to Rats and Mice

1952 • 30 citations

Tumorigenicity of the dihydrodiols of dibenzo(a,h)anthracene on mouse skin and in newborn mice.

1979 • 30 citations

Life-span investigations for carcinogenicity of some immune-stimulating, immunodepressive and neurotropic substances in Sprague-Dawley-rats

1976 • 30 citations

Separation of initiating and promoting effects of the skin carcinogen 7-bromomethylbenz(a)anthracene

1980 • 29 citations

Non-carcinogenicity of hair dyes: Lifetime percutaneous applications in mice and rabbits

1977 • 29 citations

Carcinogenicity studies on different diarylide yellow pigments in mice and rats

1978 • 29 citations

Carcinogenicity and metabolic profiles of 3-methylcholanthrene oxygenated derivatives at the 1 and 2 positions

1978 • 29 citations

Carcinogenicity of hexachlorocyclohexane (BHC) in pure inbred swiss mice

1979 • 28 citations

Effects of 7,8-Benzoflavone on Skin Tumor-Initiating Activities of Various 7- and 12-Substituted Derivatives of 7,12-Dimenthylbenz[a]anthracene in Mice2

1978 • 28 citations

Analogs of the Carcinogen 2-Acetylaminofluorene: The Isomeric 4-Acetylaminofluorene¹

1952 • 28 citations

The initiation of tumours on mouse skin by dihydrodiols derived from 7,12‐dimethylbenz(a)anthracene and 3‐methylcholanthrene

1979 • 28 citations

Toxicity of chronic benzene inhalation: CD-1 mice exposed to 300 ppm

1982 • 28 citations

Mutagen assay with Arabidopsis

1982 • 28 citations

Reaction of the Reticular Tissue of Mice with Autoimmune Hæmolytic Anæmia to 2-Aminofluorene

1962 • 28 citations

I. Diploid and duplication assay systems a report of the U.S. EPA gene-tox program

1982 • 27 citations

Cell-mediated mutagenesis and tumor-initiating activity of the ubiquitous polycyclic hydrocarbon, cyclopenta[c,d]pyrene

1982 • 27 citations

Tumors of the Esophagus and Duodenum Induced in Mice by Oral Adm.inistration of N-Ethyl-N′-Nitro-N-Nitrosoguanidine2

1974 • 27 citations

Comparative Cutaneous Carcinogenesis in the Rat

1964 • 27 citations

Carcinogenicity of Halothane in Swiss/ICR Mice

1979 • 27 citations

Effect of antioxidants and antitoxicants of isoniazid on the formation of lung tumours in mice by isoniazid and hydrazine sulphate

1982 • 26 citations

Pr�fung von Naphthalin und Anthracen auf cancerogene Wirkung an Ratten

1955 • 26 citations

Different deviation patterns of carbohydrate-metabolizing enzymes in primary rat hepatomas induced by different chemical carcinogens.

1978 • 26 citations

Esophageal and Gastric Cancers With Metastases Induced in Dogs by N -Ethyl- N ′-nitro- N -nitrosoguanidine 2

1977 • 26 citations

Early Differential Effects of 3-Methylcholanthrene and Its “K-Region” Epoxideon Mouse Skin. Possible Implication in the Two-Stage Mechanism of Tumorigenesis2

1974 • 26 citations

Long-Term Testing of Vinylidene Chloride and Chloroprene for Carcinogenicity in Rats

1980 • 26 citations

Significance of the genotoxic activities observed in vitro for 35 of 70 NTP noncarcinogens

1985 • 26 citations

Carcinogenicities of quinoline derivatives in F344 rats

1981 • 25 citations

Production of tumors in rats by 2-aminofluorene and 2-acetylaminofluorene; failure of liver extract and of dietary protein level to influence liver tumor production.

1947 • 25 citations

Incidence of pulmonary metastases for various neoplasms in BALB/cStCrlfC3H/Nctr female fed N-2-fluorenylacetamide.

1981 • 25 citations

Carcinogenic Activity of Some Benz(a)Anthracene Derivatives in Newborn Mice

1972 • 25 citations

Effect of various substituents in the 6-position on the relative carcinogenic activity of a series of benzo[a]pyrene derivatives

1980 • 24 citations

Inhibitory action of BHA on carcinogenesis in F1 and F2 descendants of mice exposed to DMBA during pregnancy

1982 • 24 citations

Influence of mutagens on the initiation of skin carcinogenesis

1964 • 24 citations

Failure of pure 1-naphthylamine to induce bladder tumors in dogs.

1980 • 24 citations

Carcinogenicity of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in the rabbit.

1967 • 23 citations

Syncarcinogenic effect of the environmental pollutants cyclopenteno[cd]pyrene and benzo[a]pyrene in mouse skin

1983 • 23 citations

Susceptibility of guinea pigs to chemical carcinogens: 7,12-Dimethylbenz(a)anthracene and urethan.

1970 • 23 citations

Development of tumors in the glandular stomach of rats after oral administration of carcinogens

1976 • 22 citations

Inhibition of azoxymethane-induced intestinal cancer by disulfiram

1978 • 22 citations

Carcinogenicity study with technical-grade dichlorodiphenyltrichloroethane and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene in hamsters.

1983 • 22 citations

Carcinogenicity and metabolism of aromatic amines in the dog.

1969 • 22 citations

Tumors of Alimentary Tract in Mice Fed Carcinogenic Hydrocarbons in Mineral-Oil Emulsions<xref ref-type="fn" rid="fn1">2</xref>

1948 • 22 citations

Intestinal tumors in mice treated with a single injection of N-nitroso-N-butylurea.

1975 • 21 citations

Carcinogenic potential of hycanthone in mice and hamsters

1979 • 21 citations

Tumorigenic activity of benzo(e)pyrene derivatives on mouse skin and in newborn mice.

1980 • 21 citations

Lack of Involvement of 6-Hydroxymethylation in Benzo[<italic>a</italic>]pyrene Skin Tumor Initiation in Mice<xref ref-type="fn" rid="FN2">2</xref>

1978 • 21 citations

Preliminary experimental contribution to the study of possible carcinogenic activity of two herbicides containing atrazine-simazine and trifuralin as active principles.

1981 • 21 citations

Isoniazid tumorigenicity in mice under different experimental conditions

1978 • 21 citations

Liposolubility as an aspect of nitrosamine carcinogenicity: Quantitative correlations and qualitative observations

1977 • 21 citations

Krebsbildung durch Aminofluorene und verwandte Körper

1955 • 21 citations

A comparison of the changes induced in rat liver by feeding low levels of aflatoxin B1 or an azo dye

1978 • 20 citations

Induction of Pulmonary Tumors in Guinea Pigs by Intravenous Injection of Methylcholanthrene and Dibenzanthracene

1952 • 20 citations

Mammary carcinogenesis in the rat by topical application of fluorenylhydroxamic acids and their acetates.

1977 • 20 citations

Inhibition of the tumor-initiating ability of the potent carcinogen 7,12-dimethylbenz(a)anthracene by the weak tumor initiator 1,2,3,4-dibenzanthracene.

1977 • 20 citations

Antineoplastic effect of chlorpromazine in chemical carcinogenesis in the hamster cheek pouch.

1972 • 20 citations

The Effect of Inactivity on Reactive Hyperaemia in the Human Calf: A Study with Strain Gauge Plethysmography

1977 • 20 citations

Lung tumour incidence in mice treated with hydrazine sulphate

1976 • 20 citations

Anthramine Carcinogenesis in the Skin of Rats. I. The Epidermis<xref ref-type="fn" rid="FN2">2</xref>

1963 • 19 citations

The chlorophyll-deficient mutant assay in barley (Hordeum vulgare) a report of the U.S. environmental protection agency Gene-Tox program

1982 • 19 citations

Effect of Trichloropropene Oxide on the Ability of Polyaromatic Hydrocarbons and Their “K-Region” Oxides To Initiate Skin Tumors in Mice and To Bind to DNA In Vitro2

1977 • 19 citations

Influence of Carcinogens on the Age Incidence of Leukemia in the High Leukemia F Strain of Mice

1942 • 19 citations

Influence of 3-methylcholanthrene on liver carcinogenesis in rats ingesting DL-ethionine, 3'-methyl-4-dimethylaminoazobenzene, and N-2-fluorenylacetamide.

1967 • 19 citations

Effect of Neonatal Androgen and Estrogen Injection on Liver Tumor Induction byN-Hydroxy-N-2-fluorenylacetamide and on the Metabolism of the Carcinogen in Rats

1968 • 19 citations

Liver and Lung Tumors in Mice Exposed at Birth to 4-Dimethylaminoazobenzene or Its 2-Methyl or 3′-Methyl Derivatives1<xref ref-type="fn" rid="FN1">2</xref>

1971 • 19 citations

Inhibition of Chemical Carcinogenesis in the Hamster Cheek Pouch by Topical Chlorpromazine

1970 • 18 citations

Perinatal carcinogenicity of isoniazid (INH) in swiss mice

1983 • 18 citations

Carcinogenicity and toxicity tests on p-phenylenediamine in F344 rats

1983 • 18 citations

Carcinogenesis in the Pituitary Dwarf Mouse. The Response to 2-Aminofluorene

1960 • 18 citations

Tumorigenicity of 7, 12-dimethylbenz[a]anthracene, its hydroxy-methylated derivatives and selected dihydrodiols in the newborn mouse

1981 • 18 citations

The carcinogenicity of some 6-substituted benzo(a)pyrene derivatives in mice

1972 • 18 citations

Beitrag zur Morphologie und Enzymhistochemie experimenteller Tumoren des Zentralnervensystem der Ratte

1970 • 18 citations

Effects of carcinogenic, noncarcinogenic, and cocarcinogenic agents on the biosynthesis of nucleic acids in mouse skin.

1969 • 18 citations

The Effect of Phenanthrene on Tumour Induction by 3,4-Benzopyrene Administered to Newly Born Mice

1963 • 18 citations

Carcinogenic activity of 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide, a food additive, in mice and rats

1977 • 17 citations

THE TUMORIGENIC EFFECT OF ETHANOL

1969 • 17 citations

Induction of lymphomas in mice by busulfan and chloramphenicol.

1981 • 17 citations

The carcinogenic activities of various derivatives of dibenzanthracene.

1962 • 17 citations

A Mode of Incipient Growth in Chemically Induced Signet Ring Cell Carcinoma of the Canine Stomach

1979 • 17 citations

Combined action of optical brighteners and ultraviolet light in the production of tumours

1970 • 17 citations

Transplacental effects of nitrosamines in Syrian hamsters

1977 • 17 citations

Hepatic carcinogenesis in thyroidectomized rats: apparent blockade at the stage of initiation.

1966 • 16 citations

Oncogenic studies on the Mongolian gerbil.

1966 • 16 citations

Butylated hydroxyanisole and lung tumor development in A/J mice*1

1984 • 16 citations

Influence of Orotic Acid on Liver Tumorigenesis in Rats Ingesting Ethionine, <italic>N-2</italic>-Fluorenylacetamide, and 3′-Methyl-Dimethylaminoazobenzene<xref ref-type="fn" rid="FN2">2</xref>

1970 • 16 citations

Carcinogenicity of 2-hydroxybenzo(a)pyrene and 6-hydroxybenzo(a)pyrene in newborn mice.

1979 • 16 citations

New carcinogenic nitrosamines in rats

1966 • 16 citations

Mammary tumours induced in Sprague-Dawley female rats by 7,12-dimethylbenz(a)anthracene and its hydroxymethyl derivatives

1968 • 16 citations

Melanotic lesions of the eye in August hooded rats induced by urethan or N-hydroxyurethan given during the neonatal period: a histopathological study.

1969 • 16 citations

Effect of l-tryptophan on diethylnitrosamine and 3′-methyl-4-n-dimethylaminoazobenzene hepatocarcinogenesis

1977 • 16 citations

Testing of chemicals for mutagenic activity with Schizosaccharomyces pombe

1983 • 15 citations

Shortening of life span caused by administration of 5-bromodeoxyuridine to neonatal rats

1981 • 15 citations

Further Studies on the Effect of Leupeptin, a Protease Inhibitor, on Induction of Bladder Tumors in Rats by N -Butyl- N -(4-hydroxybutyl)nitrosamine 2 , 3

1977 • 15 citations

Malathion and malaoxon: Histopathology reexamination of the National Cancer Institute's carcinogenesis studies

1985 • 15 citations

THE CARCINOGENIC ACTIVITIES OF N-HYDROXY-2-ACETYLAMINOFLUORENE AND ITS METAL CHELATES AS A FUNCTION OF RETENTION AT THE INJECTION SITE.

1965 • 15 citations

Effect of Dose on Urinary Bladder Carcinogenesis Induced in F344 Rats by <italic>N</italic>-[4-(5-Nitro-2-furyl)-2-thiazolyllformamide<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1979 • 15 citations

Studies on the carcinogenicity of the glucuronides of N-hydroxy-2-acetylaminofluorene and N-2-fluorenylhydroxylamine in the rat.

1971 • 15 citations

Tumorigenicity of benzo[a]pyrene 4,5-, 7,8-, 9,10- and 11,12-oxides in newborn mice

1978 • 15 citations

Carcinogenicity of Benzo[<italic>a</italic>]pyrene and Thirteen of Its Derivatives in C3H/fCum Mice<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1980 • 15 citations

The leukemogenic action of 2-acetylamionphenanthrene in the rat.

1959 • 15 citations

The effect of isonicotinic acid hydrazide on the development of tumors

1967 • 14 citations

Local carcinogenicity, rates of absorption, extent and persistence of macromolecular binding, and acute histopathological effects of N-hydroxy-1-naphthylamine and N-hydroxy-2-naphthylamine.

1984 • 14 citations

Studies of Guinea Pig Tumors II. The Induction of Malignant Tumors in Guinea Pigs by Methylcholanthrene

1962 • 14 citations

Experimental Study on Haematotoxic and Leukaemogenic Effects of Trichlorophone and Dimethoate

1974 • 14 citations

Carcinogenic activity in Sprague-Dawley rats of 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose (chlorozotocin)

1979 • 14 citations

Effects of Trypan Blue on Hepatocarcinogenesis in Rats Given Ethionine or <italic>N</italic>-2-Fluorenylacetamide<xref ref-type="fn" rid="FN2">2</xref>

1966 • 14 citations

Influence of a prolonged treatment with disulfiram andd(-)penicillamine on nitrosodiethylamine-induced biological and biochemical effects in rats

1985 • 13 citations

The experimental production of sarcoma in rats and mice by a colloidal aqueous solution of I:2:5:6‐dibenzanthracene

1935 • 13 citations

Comparative carcinogenicity of alkylating agents: comparisons of a series of alkyl and aralkyl bromides of differing chemical reactivities as inducers of sarcoma at the site of a single injection in the rat

1981 • 13 citations

[Cancer formation by aminofluorene and related substances].

1955 • 13 citations

Mutagenicity, carcinogenicity, distribution, and nitroreduction of 4-(5-nitro-2-furyl)thiazole in the rat.

1981 • 13 citations

Adenocarcinomas of the stomach induced in beagle dogs by oral administration of N-ethyl-N?-nitro-N-nitrosoguanidine

1977 • 12 citations

Long-term feeding study in C17 mice administered saccharin coated betel nut and 1,4-dinitrosopiperazine in combination

1981 • 12 citations

Lack of Susceptibility of F344 Rats to Mammary Tumor Induction by Topically Applied Fluorenylacetohydroxamic Acids and Their Acetates 2

1978 • 12 citations

Induction of tumors in the stomach and duodenum of hamsters by N-ethyl-N?-nitro-N-nitrosoguanidine

1974 • 12 citations

The Action of 2-Aminofluorene in Three Pure Strains of Mice

1948 • 12 citations

Further studies on the carcinogenicity of a food additive, AF-2, in hamsters

1979 • 12 citations

Erzeugung von Lungen- und Lebertumoren bei M�usen mit N,N?-Dinitrosopiperazin

1965 • 12 citations

Effect of Phenanthrene on Tumour-initiation by 3,4-Benzopyrene

1962 • 11 citations

Tumor initiation by N-acyloxy derivatives of piperidine and N-arylacetamides.

1975 • 11 citations

Lack of enhancing effect of mucosal regeneration following ulceration of the urinary bladder on N-butyl-N-(4-hydroxybutyl)nitrosamine carcinogenesis in rats.

1980 • 11 citations

Biological activities of dihydrodiols derived from two polycyclic hydrocarbons in rodent test systems

1979 • 11 citations

Influence of <italic>p</italic>-Hydroxypropiophenone on Liver Tumorigenesis in Rats Ingesting Ethionine and <italic>N</italic>-2-Fluorenylacetamide<xref ref-type="fn" rid="FN1">2</xref>

1963 • 11 citations

Attempts to initiate skin tumours in mice in the 2-stage system using 4-chloromethylbiphenyl (4CMB), 4-hydroxymethylbiphenyl (4HMB), and benzyl chloride (BC). Report of the experiment at 10 months

1982 • 11 citations

Induction of tumours by administration of N-dibutylnitrosamine and derivatives to infant mice

1977 • 10 citations

Zur carcinogenen Wirkung von N-Nitroso-Verbindungen

1973 • 10 citations

A comparative study of the chronic effects of magenta, paramagenta, and phenyl-?-naphthylamine in Syrian golden hamsters

1979 • 10 citations

Carcinogenic effect of dinitrosopiperazine in adult Swiss mice and after transplacental or translactational exposure.

1980 • 10 citations

Tumor production in germ-free rats fed 5-nitrofurans

1984 • 10 citations

Unterschiedliche carcinogene Wirkungen von 1-Phenyl- und 1-(Pyridyl-3)-3,3-di�thyl-triazen an BD-Ratten nach Gabe einer Einzeldosis am 1., 10. oder 30. Lebenstag

1976 • 10 citations

Absence de propriété sarcomogène chez le dibenzo [a, c] anthracène; nette activité de son dérivé 10-méthylé

1968 • 10 citations

Influence of age and sex on hepatic lesions induced by chemical carcinogens: ingestion of 3'-methyl-4-dimethylaminoazobenzene by Buffalo strain rats.

1972 • 10 citations

Tumour-initiating activities of dihydrodiols of dibenz[a,c]anthracene

1983 • 9 citations

The Development of Malignant Tumours of Mouse Skin after “Initiating” and “Promoting” Stimuli. II. The Influence of Alternate Applications of Croton Oil on Malignant Tumour-production by Repeated Applications of Dilute 9, 10-Dimethyl-1, 2-Benzanthracene (DMBA)

1956 • 9 citations

Carcinogenic Action of N-hydroxy-4-acetylaminostilbene

1963 • 9 citations

Induction of tumors in transplacental or neonatal mice administered 3′-methyl-4-dimethylaminoazobenzene or 4-aminoazobenzene☆

1983 • 9 citations

Ethionine carcinogenesis in the rat

1965 • 9 citations

REPORT ON CARCINOGENIC ACTION OF CERTAIN AGENTS ON URINARY BLADDER OF DOGS

1960 • 8 citations

Azoxymethane-Induced Liver Hemangiosarcomas in Inbred Strain-2 Guinea Pigs 2

1976 • 8 citations

SCREENING TESTS OF VARIOUS CHEMICAL SUBSTANCES AS CARCINOGENIC HAZARDS (Report 1)

1957 • 8 citations

Maleic hydrazide, carcinogenicity study in rats

1981 • 8 citations

Ratio Dependent Synergism in Azo-dye Carcinogenesis

1961 • 7 citations

Transplantable granulocytic leukemia in strain 13 guinea pigs.

1978 • 7 citations

HAS ISONICOTINIC ACID HYDRAZIDE (INH) AN ONCOGENIC EFFECT?

1965 • 7 citations

Effect of ethanol exposure during embryogenesis and the neonatal period on the incidence of hepatoma in C3H male mice.

1968 • 7 citations

Biological behavior of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide induced carcinoma of the transitional epithe-lium in the rat

1978 • 7 citations

Prevention of isoniazid tumorigenicity by antitoxicants of isoniazid in Swiss mice

1980 • 7 citations

Comparative Carcinogenicity of Some Cholanthrene Derivatives

1941 • 6 citations

Induction of Bladder Cancer in Hamsters by Repeated Intratracheal Administrations of 2-Acetylaminofluorene2

1973 • 6 citations

Triethylenemelamine: An initiator of two-stage carcinogenesis in mouse skin which lacks the potential of a complete carcinogen

1983 • 6 citations

Inertness of Sulfanilamide in Relation to Tumors in Mice

1938 • 6 citations

Restoration by Iodide of Hepatic Reactions to 2-Aminofluorene in Thyroidectomized Rats

1965 • 6 citations

A one year feeding study with carmoisine in rats

1978 • 6 citations

The Effects of Radiation and Ethionine on Rat Mammary Tumor Incidence

1969 • 6 citations

Molecular specificity of the tumorigenic action of ethionine: The inactivity of S-ethylcysteine. Action on respiratory parameters

1971 • 5 citations

Zur krebserzeugenden Wirkung von Aminophenanthrenen und ihren Derivaten

1969 • 5 citations

The UKEMS genotoxicity trial a summary of the assays for skin tumour induction in mice, the subcutaneous implant test and the sebaceous gland suppression test

1982 • 4 citations

THE EFFECT OF TETRAETHYLTHIURAM DISULPHIDE (DISULFIRAM, ANTABUSE) ON THE THYROID OF THE RAT

1958 • 4 citations

Spontaneous and induced hyperplasia and neoplasia in the mouse lung.

1966 • 4 citations

Lesions Induced in Rats by Injections of 4-Nitroquinoline-1-Oxide

1969 • 4 citations

The cytochemical demonstration of beta-glucuronidase in colon neoplasms of rats exposed to azoxymethane.

1978 • 4 citations

Tumors of the upper digestive tract of ACI/N rats given N-propyl-N-nitrosourethan in the drinking water

1976 • 4 citations

Chronic ethanol ingestion and the hepatocarcinogenicity of N‐hydroxy‐N‐2‐fluorenylacetamide

1967 • 4 citations

DEVELOPMENT OF MYOGENIC SARCOMAS IN MICE AT THE SITE OF INJECTION OF 4‐HAQO _ A STUDY ON THE MORPHOGENESIS OF TUMOR

1977 • 4 citations

Delayed effects of a single treatment of hydroxyurea to newborn mice.

1973 • 3 citations

The Effect of Cyclophosphamide on 2-Aminoanthracene Carcinogenesis in Rat Skin

1963 • 3 citations

Isonicotinic Acid Hydrazide and Urethan Carcinogenesis in suckling SWR Mice

1969 • 3 citations

Reply

1985 • 3 citations

Tumor-initiating activity of the dihydrodiols of 8-methylbenz-[a]anthracene and 8-hydroxymethylbenz[a]anthracene

1981 • 3 citations

Different tumours induced by benzo(a)pyrene and its 7,8-dihydrodiol injected into adult mouse salivary gland

1978 • 3 citations

Hepatoma induction in the rat by the subcutaneous administration of powdered 3′-methyl-p-dimethylaminoazobenzene

1978 • 2 citations

[Experimental production of sarcoma in mice with administration of reducing saccharides, especially maltose, and some effects of adenosine triphosphate on the sarcomatous proliferation of fibroblast induced by injection of reducing saccharides].

1957 • 2 citations

Chemische Induktion transplantabler Harnblasenurothelkarzinome des Hundes

1980 • 2 citations

Effect of chloramphenicol on the carcinogenicity of N-nitrosomethylurea

1978 • 1 citations

Some biological effects of 7-hydroxymethyl-12-methylbenz (a) anthracene in mice.

1973 • 1 citations

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