Biological activities of dihydrodiols derived from two polycyclic hydrocarbons in rodent test systems

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1974 • 1,144 citations

Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants

1977 • 299 citations

Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct

1976 • 244 citations

Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100

1975 • 168 citations

(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice.

1976 • 132 citations

The involvement of a diol‐epoxide in the metabolic activation of benzo(a)pyrene in human bronchial mucosa and in mouse skin

1976 • 125 citations

Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,8- and 7,8-diol-9,10-epoxides and 7,8-diol

1976 • 110 citations

Differences between products of binding of 7,12-dimethylbenz[a]anthracene to DNA in mouse skin and in a rat liver microsomal system

1978 • 100 citations

In vitro malignant transformation of mouse fibroblasts by non-K-region dihydrodiols derived from 7-methylbenz(a)anthracene, 7,12-dimethylbenz(a)anthracene, and benzo(a)pyrene.

1976 • 98 citations

Mutagenicity of metabolically activated benzo[a]anthracene 3,4-dihydrodiol: Evidence for bay region activation of carcinogenic polycyclic hydrocarbons

1976 • 96 citations

The metabolic activation of 7-methylbenz(a)anthracene in mouse skin

1977 • 75 citations

High microsome-mediated mutagenicity of the 3,4-dihydrodiol of 7-methylbenz[a]anthracene in S. typhimurium TA 98

1977 • 74 citations

Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene

1976 • 71 citations

The metabolism of some aromatic hydrocarbons by mouse embryo cell cultures

1970 • 65 citations

The metabolism of 7- and 12-methylbenz[a]-anthracene and their derivatives

1967 • 61 citations

The metabolic activation of 7-methylbenz(a)anthracene in mouse skin: High tumour-initiating activity of the 3,4-dihydrodiol

1977 • 55 citations

The metabolic activation of 7-methylbenz(a)anthracene: The induction of malignant transformation and mutation in mammalian cells by non-K-region dihydrodiols

1977 • 50 citations

Microsome-mediated mutagenicities of the dihydrodiols of 7,12-dimethylbenz[a]anthracene: High mutagenic activity of the 3,4-dihydrodiol

1978 • 42 citations

Metabolic activation of polycyclic hydrocarbons Fluorescence spectral evidence is consistent with metabolism at the 1,2‐ and 3,4‐double bonds of 7‐methylbenz[a]anthracene

1977 • 37 citations

A survey of compounds for activity in the suppression of mouse sebaceous glands.

1958 • 33 citations

The preparation of dihydrodiols from 7-methylbenz[a]anthracene

1978 • 25 citations

Induction of malignant transformation and mutagenesis by dihydrodiols derived from 7,12-dimethylbenz[a]anthracene

1978 • 21 citations

Validity of the Sebaceous Gland Test and the Hyperplasia Test for the Prediction of the Carcinogenicity of Cigarette Smoke Condensates and Their Fractions

1974 • 5 citations

[SKIN TESTS IN MICE FOR THE DETERMINATION OF CARCINOGENIC ACTIVITY: METHODOLOGICAL DISCUSSION].

1963 • 3 citations