Influence of a prolonged treatment with disulfiram andd(-)penicillamine on nitrosodiethylamine-induced biological and biochemical effects in rats

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Tissue sulfhydryl groups

1959 • 25,130 citations

Glutathione S-Transferases

1974 • 17,321 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver

1979 • 4,067 citations

Role of superoxide dismutase in cancer: a review.

1979 • 976 citations

Glutathione: Metabolism and function

1978 • 971 citations

The Solvent Extraction of Metal Chelates

1964 • 515 citations

3,4-Dihydroxyphenylethylamine β-Hydroxylase

1965 • 451 citations

Glutathione <italic>S</italic>-Transferase Activity: Enhancement by Compounds Inhibiting Chemical Carcinogenesis and by Dietary Constituents<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 325 citations

Inhibition of Chemical Carcinogenesis

1978 • 321 citations

The fate of extracellular glutathione in the rat☆

1978 • 245 citations

Copper and the Liver

1980 • 244 citations

Metabolism of disulfiram and diethyldithiocarbamate in rats with demonstration of an in vivo ethanol-induced inhibition of the glucuronic acid conjugation of the thiol

1965 • 188 citations

Purification and specificity of a human microsomal epoxide hydratase

1974 • 165 citations

Mechanism of superoxide anion scavenging reaction by bis-(salicylato)-copper(II) complex

1976 • 121 citations

Reaction of copper-zinc superoxide dismutase with diethyldithiocarbamate.

1979 • 114 citations

Regression of Aflatoxin B ₁ -Induced Hepatocellular Carcinomas by Reduced Glutathione

1981 • 103 citations

Brief Communication: Inhibition of Dimethylhydrazine-Induced Neoplasia of the Large Intestine by Disulfiram2

1975 • 103 citations

Dialkylnitrosamine bioactivation and carcinogenesis

1980 • 99 citations

Effect of Zinc on Lipid Peroxidation in Liver Microsomes and Mitochondria

1972 • 98 citations

Repressible and inducible enzymic forms of dimethylnitrosamine-demethylase

1977 • 84 citations

Antitumor Effect of a Copper Coordination Compound With Superoxide Dismutase-Like Activity2

1981 • 82 citations

Thymidine Kinase and DNA Polymerase Activity in Normal and Zinc Deficient Developing Rat Embryos

1978 • 74 citations

THE METABOLIC ACTIVATION OF CHEMICAL CARCINOGENS

1980 • 72 citations

Interactions of disulfiram and diethyldithiocarbamate with serum proteins studied by means of a gel-filtration technique

1965 • 60 citations

Glutathione Thresholds in Reactive Metabolite Toxicity

1980 • 51 citations

Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats

1976 • 50 citations

Inhibition of N-n-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in rats by administration of disulfiram in the diet.

1979 • 44 citations

Effects of diethyldithiocarbamate and penicillamine on the tissue distribution of 63NiCl2 in mice

1980 • 43 citations

The Effect of Copper Acetate on p-Dimethylaminoazobenzene Carcinogenesis in the Rat

1958 • 41 citations

The antihepatotoxic activity of dithiocarb as compared with six other thio compounds in mice

1978 • 38 citations

Distribution of S35 disulfiram and metabolites in mice, and metabolism of S35 disulfiram in the dog.

1978 • 31 citations

Studies on the metabolism of dimethylnitrosaminein vitroby rat-liver preparations.: I. Comparison with mixed-function oxidase enzymes

1982 • 24 citations

Progress in drug research, vol. 25

1982 • 23 citations

Cytosolic levels and distribution of cadmium, copper and zinc in pretumorous livers from diethylnitrosamine-exposed mice and in non-cancerous kidneys from cancer patients

1980 • 22 citations

Inhibitory Effect of Disulfiram on Rat Mammary Tumor Induction By N-2-Fluorenylacetamide and on its Metabolic Conversion To N-Hydroxy-N-2-fluorenylacetamide2

1980 • 21 citations

Benzo(a)pyrene metabolism by rat liver microsomes: effects of adding purified glutathione S-transferases A, B, and C.

1982 • 18 citations

Inhibition of Carcinogen Metabolism and Action by Disulfiram, Pyrazole, and Related Compounds

1981 • 18 citations

Failure of glutathione to prevent liver cancer development in rats initiated with diethylnitrosamine in the resistant hepatocyte model

1983 • 17 citations

Relationship between carcinogenicity and in vitro metabolism of nitrosomethylethylamine, nitrosomethyl-N-butylamine, and nitrosomethyl-(2-phenylethyl)amine labeled with deuterium in the methyl and alpha-methylene positions.

1982 • 16 citations

A half automated, non time consuming radiochemical separation scheme for determination of 25 trace elements in biological specimens

1977 • 16 citations

Effects of disulfiram on mixed function oxidase system and trace element concentration in the liver of rats

1982 • 15 citations

Zinc-induced resistance to alkylating agents: Lack of correlation between cell survival and metallothionein content

1982 • 15 citations

The effect of cupric oxyacetate on rat liver damage associated with five poisons of unrelated chemical structure.

1966 • 15 citations

On the Action of Diethyldithiocarbamate as Inhibitor of Copper-Zinc Superoxide Dismutase

1979 • 15 citations

Cancer: etiology, mechanisms, and prevention--a summary.

1980 • 14 citations

Elevation of conjugation capacity in isolated hepatocytes from BHA-treated mice

1982 • 14 citations

Effect of disulfiram on the alkylation of rat liver DNA by nitrosodiethylamine

1980 • 12 citations

γ-Glutamyltransferase and the Inhibition of Azo Dye-Produced Neoplasia by Concomitant Administration of Disulfiram23

1980 • 12 citations

Suppressive effect of concurrent administration of metal salts on carcinogenesis by 3'-methyl-4-(dimethylamino)azobenzene, and the effect of these metals on aminoazo dye metabolism during carcinogenesis.

1973 • 12 citations

Effect of copper administration on the incorporation of [3H]-thymidine into the liver DNA of rats stimulated by dimethyl-nitrosamine and diethylnitrosamine

1981 • 11 citations

Chemical interaction of disulfiram with nitrosodimethylamine after in vitro enzymatic activation

1984 • 11 citations

Inhibition of diethylnitrosamine-induced strand breaks in liver DNA by disulfiram

1977 • 10 citations

Glutathione inhibits the alkylation of liver DNA by N-nitrosodimethylamine

1983 • 10 citations

Wirkung von Disulfiram auf die Toxizit�t und Carcinogenit�t von N-Methyl-N-nitrosobenzylamin bei Ratten

1981 • 10 citations

Effect of Long-Term Disulfiram Administration on Rat Liver

1980 • 8 citations

In vitro formation of methyldiethyldithiocarbamate after the reaction of nitrosoacetoxymethylmethylamine or methylnitrosourea with disulfiram

1982 • 8 citations

MICROSOMAL ENZYMES AND THE TOXICITY OF THIONO-SULFUR COMPOUNDS

1980 • 7 citations

Mechanism of suppressive effect of basic cupric acetate on rat liver carcinogenesis by ethionine.

1976 • 7 citations

Metal Chelates of 3-Ethoxy-2-Oxobutyraldehyde Bis (Thiosemicarbazone), H2KTS

1975 • 5 citations

Chelating agents and hepatic drug metabolism in the rat.

1977 • 4 citations

Effects of Thioanions of Molybdenum and Tungsten Upon Copper Metabolism

1981 • 4 citations

Suppressive effect of copper on ethylation of rat liver DNA with ethionine in vivo.

1977 • 4 citations

Effects of Thiomolybdate in Rats Fed a High Copper Diet

1981 • 3 citations

Der Einfluß von D-Penicillamin auf den Gehalt einiger Organe an Spurenelementen sowie auf die mechanischen Eigenschaften von Kollagen / Trace Elements in Several Organs and Mechanical Properties of Collagen under the Influence of D-Penicillamin

1978 • 2 citations

Evolution of activation-detoxification enzyme patterns during precarcinogenesis in synergism: 3-Methylcholanthrene and dimethylnitrosamine

1982 • 2 citations

Metabolic activation of chemical carcinogens

1982 • 2 citations