Acid-induced unfolding and refolding transitions of cytochrome c: A three-state mechanism in water and deuterium oxide

Dominant forces in protein folding

1990 • 3,682 citations

USE OF GLASS ELECTRODES TO MEASURE ACIDITIES IN DEUTERIUM OXIDE^1,2

1960 • 2,132 citations

Protein denaturation. C. Theoretical models for the mechanism of denaturation.

1970 • 1,550 citations

The molten globule state as a clue for understanding the folding and cooperativity of globular‐protein structure

1989 • 1,446 citations

INTERMEDIATES IN THE FOLDING REACTIONS OF SMALL PROTEINS

1990 • 1,133 citations

‘Molten‐globule state’: a compact form of globular proteins with mobile side‐chains

1983 • 723 citations

The folding of hen lysozyme involves partially structured intermediates and multiple pathways

1992 • 719 citations

Structural Characterization of a Partly Folded Apomyoglobin Intermediate

1990 • 708 citations

The Stability of Globular Protein

1975 • 648 citations

Mechanism of acid-induced folding of proteins

1990 • 560 citations

Acid-induced folding of proteins.

1990 • 555 citations

Protein folding: Hypotheses and experiments

1987 • 544 citations

Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig .alpha.-lactalbumin

1989 • 473 citations

Conformational states in .beta.-lactamase: molten-globule states at acidic and alkaline pH with high salt

1989 • 404 citations

Structural description of acid-denatured cytochrome c by hydrogen exchange and 2D NMR

1990 • 306 citations

Molten globule intermediates and protein folding

1991 • 281 citations

Structure and dynamics of the acid-denatured molten globule state of .alpha.-lactalbumin: a two-dimensional NMR study

1993 • 248 citations

The folding of an enzyme

1992 • 247 citations

Molten Globule of Cytochrome c Studied by Small Angle X-ray Scattering

1993 • 232 citations

Stable submolecular folding units in a non-compact form of cytochrome c

1991 • 220 citations

Early steps in cytochrome c folding probed by time-resolved circular dichroism and fluorescence spectroscopy

1992 • 219 citations

Detection and characterization of a folding intermediate in barnase by NMR

1990 • 212 citations

Unfolded proteins, compact states and molten globules

1992 • 199 citations

Probing the stability of a partly folded apomyoglobin intermediate by site-directed mutagenesis

1991 • 179 citations

Structure and stability of the molten globule state of guinea pig .alpha.-lactalbumin: A hydrogen exchange study

1993 • 177 citations

The molten globule intermediate of apomyoglobin and the process of protein folding

1993 • 175 citations

Fluorescence and the structure of proteins. I. Effects of substituents on the fluorescence of indole and phenol compounds

1963 • 165 citations

Truncated staphylococcal nuclease is compact but disordered.

1992 • 162 citations

Phase diagram for acidic conformational states of apomyoglobin

1990 • 156 citations

Characterization of a partially denatured state of a protein by two-dimensional NMR: reduction of the hydrophobic interactions in ubiquitin

1991 • 154 citations

Thermodynamic characterization of cytochrome c at low pH

1992 • 153 citations

Protein stability: electrostatics and compact denatured states.

1991 • 151 citations

The molten globule protein conformation probed by disulphide bonds

1991 • 143 citations

Melittin binding causes a large calcium-dependent conformational change in calmodulin.

1989 • 141 citations

Role of electrostatic repulsion in the acidic molten globule of cytochrome c

1991 • 137 citations

Acid induced conformational transition of denatured cytochrome c in urea and guanidine hydrochloride solutions

1975 • 109 citations

Spin state and unfolding equilibria of ferricytochrome c in acidic solutions.

1982 • 99 citations

Small-angle x-ray scattering study of calmodulin bound to two peptides corresponding to parts of the calmodulin-binding domain of the plasma membrane calcium pump

1991 • 95 citations

Mechanism of the conformational transition of melittin

1992 • 81 citations

Stabilization of the globular structure of ferricytochrome c by chloride in acidic solvents

1975 • 80 citations

Anion and pH-dependent conformational transition of an amphiphilic polypeptide

1991 • 69 citations

Effects of D2O on the Association-Dissociation Equilibrium in Subunit Proteins

1970 • 66 citations

The three states of globular proteins: Acid denaturation

1991 • 66 citations

Protein folding in vitro

1992 • 60 citations

Cold denaturation and 2H2O stabilization of a staphylococcal nuclease mutant.

1991 • 40 citations

Increased conformational stability of mitochondrial soluble ATPase (F1) by substitution of H2O for D2O

1978 • 35 citations

Stability of butyrylcholinesterase: thermal inactivation in water and deuterium oxide

1988 • 34 citations