The molten globule intermediate of apomyoglobin and the process of protein folding

The molten globule state as a clue for understanding the folding and cooperativity of globular‐protein structure

1989 • 1,446 citations

Hydrogen exchange and structural dynamics of proteins and nucleic acids

1983 • 1,329 citations

Study of the “molten globule” intermediate state in protein folding by a hydrophobic fluorescent probe

1991 • 1,231 citations

‘Molten‐globule state’: a compact form of globular proteins with mobile side‐chains

1983 • 723 citations

The folding of hen lysozyme involves partially structured intermediates and multiple pathways

1992 • 719 citations

Structural Characterization of a Partly Folded Apomyoglobin Intermediate

1990 • 708 citations

Evidence for a molten globule state as a general intermediate in protein folding

1990 • 677 citations

Structure of myoglobin refined at 2·0 Å resolution

1977 • 676 citations

α‐lactalbumin: compact state with fluctuating tertiary structure?

1981 • 611 citations

Helix to helix packing in proteins

1981 • 556 citations

Acid-induced folding of proteins.

1990 • 555 citations

Protein folding: Hypotheses and experiments

1987 • 544 citations

Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig .alpha.-lactalbumin

1989 • 473 citations

Packing of α-helices: Geometrical constraints and contact areas

1978 • 366 citations

Hydrogen exchange and the dynamic structure of proteins

1982 • 308 citations

Structural description of acid-denatured cytochrome c by hydrogen exchange and 2D NMR

1990 • 306 citations

Evidence for identity between the equilibrium unfolding intermediate and a transient folding intermediate: a comparative study of the folding reactions of .alpha.-lactalbumin and lysozyme

1986 • 254 citations

Three-state denaturation of α-lactalbumin by guanidine hydrochloride

1976 • 249 citations

Pulsed H/D-exchange studies of folding intermediates

1993 • 245 citations

Residual structure in large fragments of staphylococcal nuclease: effects of amino acid substitutions

1989 • 234 citations

Three-state analysis of sperm whale apomyoglobin folding

1993 • 226 citations

Early steps in cytochrome c folding probed by time-resolved circular dichroism and fluorescence spectroscopy

1992 • 219 citations

Detection and characterization of a folding intermediate in barnase by NMR

1990 • 212 citations

How does protein folding get started?

1989 • 184 citations

Probing the stability of a partly folded apomyoglobin intermediate by site-directed mutagenesis

1991 • 179 citations

Structure and stability of the molten globule state of guinea pig .alpha.-lactalbumin: A hydrogen exchange study

1993 • 177 citations

A folding model of α-lactalbumin deduced from the three-state denaturation mechanism

1977 • 173 citations

Truncated staphylococcal nuclease is compact but disordered.

1992 • 162 citations

Phase diagram for acidic conformational states of apomyoglobin

1990 • 156 citations

Ca2+ Alteration in the Unfolding Behavior of α-Lactalbumin1

1986 • 143 citations

The molten globule protein conformation probed by disulphide bonds

1991 • 143 citations

Molecular dynamics simulations of the unfolding of apomyoglobin in water

1993 • 118 citations

Detection and characterization of an early folding intermediate of T4 lysozyme using pulsed hydrogen exchange and two-dimensional NMR

1992 • 107 citations

Characterization of “native” apomyoglobin by molecular dynamics simulation

1992 • 64 citations

Conformation of a T cell stimulating peptide in aqueous solution

1989 • 50 citations