Pharmacokinetic and Pharmacodynamic Parameters Affected by RE Cell Activators

Virus interference. I. The interferon

1957 • 3,331 citations

Development of Arthritis, Periarthritis and Periostitis in Rats Given Adjuvants.

1956 • 847 citations

Progress in Liver Diseases

1965 • 697 citations

Multiplicity of mammalian microsomal cytochromes P-45.

1979 • 633 citations

CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT

1963 • 523 citations

The Clearance, Tissue Distribution, and Cellular Localization of Intravenously Injected Lipopolysaccharide in Rabbits

1979 • 427 citations

The Role of Endotoxin in Liver Injury

1975 • 291 citations

ALTERED THEOPHYLLINE PHARMACOKINETICS DURING ACUTE RESPIRATORY VIRAL ILLNESS

1978 • 283 citations

Progress in Liver Diseases.

1979 • 261 citations

Substrate interaction with cytochrome P-450

1981 • 207 citations

Cellular and Molecular Mechanisms of Action of Bacterial Endotoxins

1979 • 198 citations

Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents

1976 • 194 citations

Uptake by liver cells of endotoxin following its intravenous injection.

1981 • 187 citations

Depression of hepatic gluconeogenesis and the hypoglycemia of endotoxin shock

1974 • 180 citations

Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity

1976 • 174 citations

Chemistry and Immunochemistry of Bacterial Lipopolysaccharides as Cell Wall Antigens and Endotoxins

2015 • 168 citations

Time course of cellular distribution of endotoxin in liver, lungs and kidneys of rats.

1982 • 138 citations

Muramyl peptides

1981 • 135 citations

Decreased elimination of theophylline after influenza vaccination.

1980 • 133 citations

Bordetella pertussis toxins

1982 • 109 citations

Hepatic microsomal drug metabolism after administration of endotoxin in rats

1976 • 108 citations

Depression of Aminopyrine Metabolism by Influenza Vaccination

1981 • 106 citations

EFFECTS OF INTERFERON‐INDUCING AGENTS ON HEPATIC CYTOCHROME P‐450 DRUG METABOLIZING SYSTEMS*

1980 • 104 citations

Histamine-sensitizing factors from microbial agents, with special reference to Bordetella pertussis

1968 • 104 citations

Anionic polymeric drugs

1980 • 101 citations

Classes of hepatic microsomal mixed function oxidase inducers

1979 • 100 citations

Allergic Diseases of Infancy, Childhood, and Adolescence

1980 • 95 citations

Sites of tissue binding and uptake in vivo of bacterial lipopolysaccharide-high density lipoprotein complexes: studies in the rat and squirrel monkey.

1981 • 95 citations

Inhibition of drug-metabolizing enzymes in the rat after bacillus calmette-guérin treatment

1976 • 91 citations

Advances in Immunopharmacology

1989 • 89 citations

Cytochrome P-450 heme and the regulation of δ-aminolevulinic acid synthetase in the liver

1976 • 87 citations

Homogeneous interferon from E. coli depresses hepatic cytochrome P-450 and drug biotransformation

1982 • 84 citations

The effect of Corynebacterium parvum on the structure and function of the lymphoid system in mice

1974 • 82 citations

Fate of 51Cr-labeled lipopolysaccharide in tissue culture cells and livers of normal mice

1976 • 80 citations

Effects of polyribonoinosinic acid polyribocytidylic acid and a mouse interferon preparation on cytochrome P-450-dependent monooxygenase systems in cultures of primary mouse hepatocytes.

1978 • 80 citations

Endotoxins of gram-negative bacteria

1981 • 79 citations

Endotoxin effects on the liver

1977 • 76 citations

The effects of adjuvant-induced arthritis on the liver metabolism of drugs in rats

1970 • 73 citations

Effects of three recombinant human leukocyte interferons on drug metabolism in mice.

1982 • 69 citations

Depression of the hepatic cytochrome P-450 mono-oxygenase system by administered tilorone (2,7-bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride).

1976 • 66 citations

Isolation and comparison of endoplasmic reticulum membranes and their mixed function oxidase activities from mammalian extrahepatic tissues

1979 • 64 citations

Apocytochrome P-450: reconstitution of functional cytochrome with hemin in vitro.

1975 • 62 citations

Stimulation of heme oxygenase in macrophages and liver by endotoxin.

1974 • 60 citations

Reticuloendothelial cells as the site of sulfanilamide acetylation in the rabbit.

1965 • 57 citations

Impaired drug metabolism in rats with adjuvant-induced arthritis: a brief review.

1973 • 56 citations

Effect of adjuvant disease in rats on cyclophosphamide and isophosphamide metabolism

1973 • 55 citations

Effect of endotoxin on tryptophan pyrrolase and delta-aminolaevulinate synthase: evidence for an endogenous regulatory haem fraction in rat liver

1977 • 55 citations

Interferon-mediated depression of cytochrome P-450-dependent drug biotransformation.

1981 • 53 citations

Adjuvant-induced arthritis and drug-metabolizing enzymes

1976 • 51 citations

Endotoxin and the liver. II. Effect of tolerance on carbon tetrachloride-induced injury.

1973 • 48 citations

Decreased liver and lung drug-metabolizing activity in mice treated with Corynebacterium parvum.

1976 • 47 citations

Type II interferon induction and passive transfer depress the murine cytochrome P-450 drug metabolism system

1980 • 44 citations

Depression of hepatic cytochrome P-450-dependent mixed function oxidases durino infection with encephalomyocarditis virus

1981 • 43 citations

The hepatocellular uptake and biliary excretion of endotoxin in the rat

1981 • 43 citations

Allergic diseases of infancy, childhood, and adolescence

1980 • 41 citations

Decrease in the activity of the drug-metabolizing enzymes of rat liver following the administration of tilorone hydrochloride.

1976 • 40 citations

Pyran and Polyribonucleotides: Differences in Biological Activities

1972 • 38 citations

Immuno-modulating properties of interferons

1982 • 38 citations

Stimulation of Aryl Hydrocarbon Hydroxylase Induction in Cell Cultures by Interferon

1973 • 37 citations

Pharmacokinetic studies of interferons

1981 • 36 citations

In Vivo vs In Vitro Effects of Endotoxin on Glycogenolysis, Gluconeogenesis, and Glucose Utilization

1977 • 36 citations

Endotoxin and the liver

1978 • 35 citations

Impaired Drug Metabolism in Rats Associated with Acute Inflammation: A Possible Assay for Anti-injury Agents

1974 • 33 citations

Effect of interferon inducing agents (polyriboinosinic acid . polyribocytidylic acid and tilorone) on the heme turnover of hepatic cytochrome P-450.

1980 • 33 citations

The deleterious effect of Bordetella pertussis vaccine and poly(rI.rC) on the metabolism and disposition of phenytoin.

1979 • 32 citations

Role of mononuclear phagocytes in decreased hepatic drug metabolism following administration of Corynebacterium parvum

1979 • 32 citations

The turnover of cytochrome P450b

1982 • 31 citations

Histamine-sensitizing factors from microbial agents, with special reference to Bordetella pertussis.

1968 • 30 citations

Endotoxin-induced release of tumour necrosis factor and interferon in vivo is inhibited by prior adrenoceptor blockade

1982 • 26 citations

Mechanism of the Antiviral Activity Resulting from Sequential Administration of Complementary Homopolyribonucleotides to Cell Cultures

1972 • 26 citations

Enhanced phenobarbital induction of liver microsomal drug-metabolizing enzymes in mice infected with murine hepatitus virus

1963 • 25 citations

Interferons and Interferon Inducers

1982 • 25 citations

Evaluation of effects of interferon and interferon inducers on the immune response

1977 • 24 citations

The effects of maleic anhydride-divinyl ether (MVE) copolymers on hepatic microsomal mixed-function oxidases and other biologic activities.

1979 • 24 citations

Influence of sex and Freund's adjuvant on liver N-acetyltransferase activity and elimination of sulphadimidine in urine of rats

1977 • 24 citations

Kinetics of hepatic cytochrome P-450-dependent mono-oxygenase systems

1980 • 23 citations

Screening and assessment of antiinflammatory drugs.

1979 • 22 citations

The contribution of gut-derived endotoxins to liver injury.

1979 • 22 citations

Cytochrome P-450 linked mixed function oxidase turnover of microsomal components and effects of inducers on the turnover phospholipids, proteins and specific enzymes

1980 • 21 citations

Hepatic cytochrome P-450.

1981 • 21 citations

Abnormal drug metabolism in rats after an inflammatory insult

1973 • 20 citations

Endotoxic Glycolipid as a Potent Depressor of the Hepatic Drug‐Metabolizing Enzyme Systems in Mice*

1979 • 20 citations

Inhibition of drug-metabolizing enzymes in the mouse after treatment with host-mediating antitumor drugs

1977 • 19 citations

Effects of Passive Transfer and Induction of Gamma (Type II Immune) Interferon Preparations on the Metabolism of Diphenylhydantoin by Murine Cytochrome P-450

1982 • 19 citations

Induction of acetylating capacity with complete Freund's adjuvant and hydrocortisone in the rabbit.

1981 • 19 citations

Involvement of a heat-stable and heat-labile component of Bordetella pertussis in the depression of the murine hepatic mixed-function oxidase system

1980 • 18 citations

Selective depression of hepatic cytochrome P-450 hemoprotein by interferon inducers

1980 • 18 citations

Elimination and distribution of phenylbutazone in rats during the course of adjuvant-induced arthritis.

1976 • 17 citations

CORYNEBACTERIUM PARVUM AND ANÆSTHETICS

1975 • 17 citations

I. IMMUNOLOGICAL AND OTHER BIOLOGICAL ACTIVITIES OF BORDETELLA PERTUSSIS ANTIGENS

1963 • 16 citations

Endotoxin depression of hepatic mixed function oxidase system in C3H/HeJ and C3H/HeN mice

1980 • 16 citations

Effect of benzo(a)pyrene induction of liver and lung metabolism in adjuvant-diseased rats

1975 • 16 citations

Enhanced Toxicity for Mice of Combinations of Bacterial Endotoxin with Antitumor Drugs

1973 • 15 citations

Depression of hepatic drug-metabolizing enzyme activity by B. pertussis vaccination

1977 • 15 citations

Effect of endotoxin and its degradation products on hepatic mixed-function oxidase and heme enzyme systems in mice

1982 • 13 citations

Endotoxin inhibition of dexamethasone induction of tryptophan oxygenase in suspension culture of isolated rat parenchymal cells

1981 • 13 citations

Effect of viral infection on drug metabolism and pesticide disposition in ducks

1978 • 13 citations

Depression of hepatic mixed-function oxidase activity by B. pertussis in splenectomized and athymic nude mice

1981 • 12 citations

An Endotoxin‐Induced Serum Factor that Depresses Hepatic δ‐Aminolevulinic Acid Synthetase Activity and Cytochrome P‐450 Levels in Mice

1981 • 12 citations

Binding sites for endotoxic lipopolysaccharide on the plasma membrane of isolated rabbit hepatocytes.

1979 • 12 citations

Clinical application of interferons and their inducers

1986 • 11 citations

Prolongation of barbiturate sleeping time in mice by stimulation of the reticuloendothelial system (RES).

1966 • 11 citations

Effects of Intravenous and Intracutaneous Bacillus Calmette-Guérin Application on the Drug-Metabolizing System of the Liver

1980 • 11 citations

The effect of stimulants and depressants of reticuloendothelial activity on drug metabolism.

1971 • 11 citations

Effects of endotoxin-tolerance on in vivo drug metabolism in mice.

1980 • 11 citations

Continued Studies on the Effect of Interferon Inducers on the Hepatic Microsomal Mixed-Function Oxidase System of Rats and Mice

1983 • 10 citations

Poly I·Poly C and endotoxins share immunosuppressive properties and increase the toxicity of α-amanitin and hexobarbital

1971 • 10 citations

Chloroquine pharmacokinetics in tissues of pyrogen treated rats and implications for chloroquine related pruritus.

1980 • 10 citations

Effects of Corynebacterium parvum vaccine on drug metabolism in the mouse.

1977 • 9 citations

Depression of Hepatic Biotransformations by Chemical Immunoadjuvants

1981 • 9 citations

Endotoxin Induced Changes in the Pharmacokinetics of Warfarin in Rabbits

1978 • 9 citations

Increased acetylation and elimination of sulphadimidine in rats

1981 • 9 citations

Defective drug metabolism in rat liver in endotoxin shock.

1973 • 8 citations

Alteration of hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation

1977 • 8 citations

Effect of Interferon on Murine Cytochrome P-450: Effect of Partially Purified Antigen-Specific Interferon-Gamma

1983 • 8 citations

Changes of Pharmacokinetics and Metabolism of Sulfadimidine in Endotoxin Pretreated Rabbits

1980 • 7 citations

Effects of Interferon Inducers and Viral Infection on the Metabolism of Drugs

1981 • 7 citations

Lethal interaction of bacterial lipopolysaccharide and naturally occurring cannabinoids.

1978 • 7 citations

The mechanism of interferon production

1982 • 7 citations

Reduced drug metabolism in isolated hepatocytes from adjuvant arthritic rats.

1983 • 7 citations

Lack of effect of immunotherapy with BCG and Corynebacterium parvum on hepatic drug hydroxylation in man

1979 • 7 citations

Biotransformation of drugs in rats treated with a synthetic muramyl dipeptide, (MDP)

1983 • 7 citations

Effect of bacterial lipopolysaccharide, lipid A, and concanavalin a on lethality of 5-fluorouracil for mice

1975 • 6 citations

Investigation of adrenergic and prostaglandin influences in the endotoxin alteration of hepatic heme oxygenase, microsomal mixed-function oxidase, and glucocorticoid-induced tryptophan oxygenase activities

1983 • 6 citations

Interactions of the interferon system with cellular metabolism

1986 • 6 citations

Pentobarbital sleeping time and RES stimulation.

1965 • 6 citations

Effects of endotoxin on the pharmacology of antineoplastic agents

1981 • 6 citations

Sequential administrations of polyriboinosinic acid and polyribocytidylic acid induce interferon and depress the hepatic cytochrome P-450-dependent monooxygenase system

1982 • 5 citations

Correlation of induced drug metabolism with titer of duck hepatitis virus in chickens.

1977 • 4 citations

Antipyretic and pharmacokinetic evaluation of coumarin in the rabbit after endotoxin administration.

1982 • 4 citations

Alterations in the pharmacokinetics of 3H-delta9-tetrahydrocannabinol in mice by bacterial endotoxin.

1978 • 3 citations

Immunostimulants and Hepatic Drug Metabolism

1981 • 3 citations

Drug interaction of antitumor drugs. III. Antitumor activity of tegafur in lipopolysaccharide-treated mice.

1982 • 3 citations

Failure of Corynebacterium parvum to inhibit antipyrine metabolism in man

1980 • 2 citations

Pharmacokinetics and metabolism of tolmetin in normal and adjuvant arthritic Lewis rats

1982 • 2 citations

Reticuloendothelial stimulation and drug metabolism.

1970 • 2 citations

Immuno-enhancement and Drug Elimination Kinetics In Vivo

1981 • 2 citations

Effect of adjuvant polyarthritis on liver alcohol dehydrogenase in the rat

1979 • 1 citations

Deleted Work

1955 • 0 citations