Substrate interaction with cytochrome P-450

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

A New Cytochrome in Liver Microsomes

1962 • 658 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems

1965 • 503 citations

Microsomes and Drug Oxidations

1970 • 463 citations

Coupling of spin, substrate, and redox equilibriums in cytochrome P450

1976 • 424 citations

Drug interaction with hepatic microsomal cytochrome.

1966 • 335 citations

SPIN-STATE CHANGES IN CYTOCHROME P-450 _cam ON BINDING OF SPECIFIC SUBSTRATES

1970 • 266 citations

Camphor binding by Pseudomonas putida cytochrome P-450

1971 • 262 citations

Ligand interactions with cytochrome P-450. I. Binding of primary amines

1969 • 227 citations

Cytochrome P-450 of liver microsomes—One pigment or many

1968 • 224 citations

The absorption spectra, magnetic moments and the binding of iron in some haemoproteins

1961 • 202 citations

THE LIGHT REVERSIBLE CARBON MONOXIDE INHIBITION OF THE STEROID C21-HYDROXYLASE SYSTEM OF THE ADRENAL CORTEX.

1963 • 189 citations

Biological hydroxylation mechanisms

1973 • 186 citations

Substrate interaction with hydroxylase system in liver microsomes

1966 • 183 citations

Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.

1972 • 180 citations

Binding of¹⁴C-Carbon Tetrachloride to Microsomal Proteinsin vitroand Formation of CHCl₃by Reduced Liver Microsomes

1973 • 177 citations

Ligand interactions with hemoprotein P-450. II. Influence of phenobarbital and methylcholanthrene induction processes on P-450 spectra

1969 • 141 citations

Microsomes and Drug Oxidations

1977 • 131 citations

Spin state control of the hepatic cytochrome P450 redox potential

1979 • 130 citations

Glycerol as an Enzyme-Stabilizing Agent: Effects on Aldehyde Dehydrogenase

1972 • 128 citations

Mössbauer studies of cytochrome P-450_cam

1973 • 127 citations

Studies on the Kinetics of Cytochrome P-450 Reduction in Rat Liver Microsomes

1970 • 123 citations

Sex differences in drug metabolism by rat liver microsomes.

1967 • 122 citations

Spectrophotometric properties of a triton-clarified steroid 21-Hydroxylase system of adrenocortical microsomes

1965 • 121 citations

Studies on the Substrate Interactions with P-450 in Drug Hydroxylation by Liver Microsomes

1967 • 121 citations

Ferrihemoprotein Hydroxides: A Correlation Between Magnetic and Spectroscopic Properties

1964 • 120 citations

Purified liver microsomal cytochrome P-450. Electron-accepting properties and oxidation-reduction potential.

1975 • 120 citations

The nature of the reverse type I (modified type II) spectral change in liver microsomes

1972 • 116 citations

Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation

1969 • 108 citations

On the Hydroxylation of Cyclohexane in Rat Liver Microsomes

1969 • 101 citations

Studies on Cytochrome c Peroxidase

1966 • 100 citations

Metyrapone interaction with hepatic microsomal cytochrome P-450 from rats treated with phenobarbital

1969 • 98 citations

Microsomal mixed-function oxidations: the metabolism of xenobiotics.

1965 • 95 citations

Temperature dependence of cholesterol binding to cytochrome P-450scc of the rat adrenal. Effect of adrenocorticotropic hormone and cycloheximide.

1976 • 89 citations

An Electron Spin Resonance Study of Microsomal Electron Transport

1962 • 88 citations

Pseudomonas putida cytochrome P-450. The effect of complexes of the ferric hemeprotein on the relaxation of solvent water protons

1975 • 83 citations

Correlation of type I, type II, and reverse type I difference spectra with absolute changes in spin state of hepatic microsomal cytochrome P-450 iron from five mammalian species

1978 • 78 citations

Cytochrome P-450 difference spectra: effect of chemical structure on type II spectra in mouse hepatic microsomes.

1974 • 78 citations

Ethanol binding to hepatic microsomes—its increase by ethanol consumption

1971 • 76 citations

Electron Paramagnetic Resonance Study of the High- and Low-Spin Forms of Cytochrome P-450 in Liver and in Liver Microsomes from a Methylcholanthrene-Treated Rabbit

1970 • 76 citations

Mechanism of cholestasis. 1. Effect of bile acids on microsomal cytochrome P-450 dependent biotransformation system

1970 • 74 citations

Substrate binding to hepatic microsomal cytochrome P-450. Influence of the microsomal membrane.

1978 • 72 citations

Partial purification and properties of cytochromes P-450 and P-448 from rat liver microsomes

1972 • 72 citations

On the problem of possible other forms of cytochrome P450 in liver microsomes

1969 • 70 citations

Temperature-dependent spin equilibrium of microsomal and solubilized cytochrome P-450 from rat liver

1979 • 69 citations

Studies on the Substrate-induced Spectral Change of Cytochrome P-450 in Liver Microsomes1

1975 • 67 citations

Substrate-induced Changes in Visible Absorption and Electron Spin Resonance Properties of Adrenal Cortex Mitochondrial P450

1970 • 66 citations

A study of the interaction of a series of substituted barbituric acids with the hepatic microsomal monooxygenase

1972 • 66 citations

Studies on P-450

1969 • 64 citations

The effect of ethanol on drug oxidations in vitro and the significance of ethanol–cytochrome P-450 interaction

1973 • 63 citations

Comparative study of two highly purified forms of liver microsomal cytochrome P-450: Circular dichroism and other properties

1979 • 61 citations

Kinetic experiments on the binding of metyrapone to liver microsomes

1969 • 59 citations

The effects of unsaturated fatty acids on hepatic microsomal drug metabolism and cytochrome P-450

1969 • 56 citations

EPR measurements of substrate interaction with cytochrome P-450

1966 • 55 citations

Effect of hexane and carbon tetrachloride on microsomal cytochrome (P450)

1967 • 54 citations

The Low‐Spin ⇌ High‐Spin Transition of Camphor‐Bound Cytochrome P‐450

1977 • 52 citations

The effect of microsomal fatty acids and other lipids on the spin state of partially purified cytochrome P-450.

1980 • 51 citations

Heterogeneity of cytochrome P‐450 in rat liver microsomes: Selective interaction of metyrapone and SKF 525‐A with different fractions of microsomal cytochrome P‐450

1975 • 50 citations

Studies on P-450: V. On the Substrate-Induced Spectral Change of P-450 Solubilized from Bovine Adrenocortical Mitochondria<xref ref-type="fn" rid="fn1"><sup>*</sup></xref>

1969 • 48 citations

Newer aspects of substrate binding to cytochrome P-450.

1973 • 46 citations

Effect of substrate on the spin state of cytochrome P-450 in hepatic microsomes

1973 • 46 citations

Electron paramagnetic resonance and temperature dependent spin state studies of ferric cytochrome P-450 from Rhizobium japonicum

1972 • 45 citations

Quantitative analysis of the spin equilibrium of cytochrome LM-2 fraction from rabbit liver microsomes

1978 • 44 citations

Characteristics of guinea pig liver and adrenal monooxygenase systems.

1970 • 43 citations

Studies on the EPR and Light Absorption Spectra of Horse Erythrocyte Catalase and Its Derivatives

1968 • 42 citations

Mechanism of cholestasis

1971 • 41 citations

Fatty Acid Interaction with the Hydroxylating Enzyme System of Rat Liver Microsomes

1969 • 41 citations

The effects of temperature and substrates on component reactions of the hepatic microsomal mixed-function oxidase.

1972 • 39 citations

Studies on the relationship between the effects of various substances on absorption spectrum of cytochrome P-450 and the reduction of p-nitrobenzoate by mouse liver microsomes.

1969 • 39 citations

Magnetic circular dichroism of purified forms of rabbit liver cytochromes P-450 and P-420

1978 • 38 citations

Evidence for the existence of a high spin—low spin equilibrium in liver microsomal cytochrome P‐450

1977 • 37 citations

Biphenyl Hydroxylations and Spectrally Apparent Interactions with Liver Microsomes from Hamsters Pre-treated with Phenobarbitone and 3-Methylcholanthrene

1975 • 37 citations

The rate-limiting step in aminopyrine demethylase of rat liver microsomes

1970 • 36 citations

Induction of liver microsomal mixed-function oxidases by volatile hydrocarbons

1976 • 36 citations

The interaction of vinyl chloride with rat hepatic microsomal cytochrome P-450 in vitro

1977 • 36 citations

Substrate induced spin state changes in cytochrome P450

1969 • 35 citations

Cytochrome P-450 optical difference spectra of insecticides. Comparative study

1975 • 34 citations

The metabolism in vitro and hepatic microsomal interactions of some enantiomeric drug substrates

1970 • 34 citations

Analysis of a thermal equilibrium phenomenon between high-spin and low-spin states of ferrimyoglobin azide

1968 • 33 citations

Hydroperoxides and superoxides in microsomal oxidations

1978 • 33 citations

Studies on adrenal cortical cytochrome P-450

1968 • 32 citations

Studies on P-450. III. On the Absorption Spectrum of P-450 in Rabbit Liver Microsomes

1967 • 32 citations

Hydroxylation of Aliphatic Compounds by Liver Microsomes, II. Effect of Phenobarbital Induction in Rats on Specific Activity and Cytochrome P-450 Substrate Binding Spectra

1970 • 31 citations

Organic Solvent Extraction of Liver Microsomal Lipid: II. Effect on the Metabolism of Substrates and Binding Spectra of Cytochrome P-450

1974 • 30 citations

Ligand Binding of Organic Sulfides to Microsomal Cytochrome P‐450

1975 • 30 citations

Ks values of some homologous series of barbiturates and the relationship with the lipophilicity and metabolic clearance

1977 • 30 citations

Relationship between difference spectra and metabolism

1970 • 28 citations

Spectral interactions of a series of chlorinated hydrocarbons with cytochrome P‐450 of liver microsomes from variously‐treated rats

1975 • 28 citations

The magnetic susceptibility of reduced cytochrome P-450cam

1975 • 28 citations

The cytochrome P-450 Substrate optical difference spectra of pesticides with mouse hepatic microsomes

1972 • 27 citations

The interaction of hepatic microsomal cytochrome P-450 with fluroxene (2,2,2-trifluoroethyl vinyl ether) in vitro

1976 • 24 citations

Redox properties of liver cytochrome P-450

1972 • 24 citations

A new class of inhibitory cytochrome P-450 complexes formed during metabolism: A comparison with amphetamine and SKF 525-A type complexes

1976 • 24 citations

Effects of extraction with isooctane upon the properties of liver microsomes.

1971 • 24 citations

Interactions of prostaglandins with hepatic microsomal cytochrome P-450

1974 • 23 citations

Cocaine-induced hepatotoxicity

1988 • 22 citations

Ionization Dependence of Camphor Binding and Spin Conversion of the Complex between Cytochrome P‐450 and Camphor

1977 • 22 citations

Effect of Phenobarbital and_3,4-Benzpyrene Treatment of Rats on the Microsomal Binding and Hydroxylation of Nortriptyline and Desmethyl-imipramine: Evidence for Qualitative Changes in Cytochrome P-450-Ligand Interaction following Phenobarbital Pretreatment

1972 • 22 citations

The relationship between the pH-induced spectral change in ferriprotoheme and the substrate-induced spectral change of the hepatic microsomal mixed-function oxidase.

1968 • 21 citations

Temperature-dependent and -induced spectral characteristics and transitions of liver microsomes

1977 • 19 citations

The effects of albumin upon the spectral changes and metabolism by the hepatic microsomal fraction

1977 • 18 citations

Spectral interactions of marihuana constituents (cannabinoids) with rat liver microsomal monooxygenase system

1972 • 18 citations

Effect of substrates on hepatic microsomal cytochrome P-450.

1968 • 18 citations

A soluble methylene hydroxylase system: structure and role of cytochrome P-450 and iron-sulfur protein components.

1968 • 16 citations

The importance of the spin equilibrium in cytochrome P-450 for the reduction rate of the heme iron

1979 • 15 citations

Quantitative analysis of the spin equilibrium of cytochrome P-450 LM2 fraction from rabbit liver microsomes

1979 • 13 citations

Binding of R and S warfarin to hepatic microsomal cytochrome P-450

1977 • 12 citations

KINETIC AND SPECTRAL EVIDENCE FOR MULTIPLE SPECIES OF CYTOCHROME P-450 IN LIVER MICROSOMES

1977 • 11 citations

Spectral studies of the binding of O,O-diethyl p-nitrophenylphosphorothionate (parathion) to cytochrome P-450

1972 • 11 citations

NADH-synergism of NADPH-dependent O-dealkylation of type II compounds, p-anisidine and p-phenetidine, in rat liver microsomes

1977 • 11 citations

The effects of some stimulators (inducers) of hepatic microsomal drug-metabolizing enzyme activity on substrate-induced difference spectra in rat liver microsomes.

1971 • 11 citations

The Effects of Sulphydryl Reagents on the Binding and Mixed Function Oxidation of Hexobarbital in Rat Hepatic Microsomes

1975 • 11 citations

On the significance of drug-induced spectral changes in liver microsomes.

1972 • 10 citations

Cytochrome P-450—IV. Stability of cytochrome P-450 and conversion to cytochrome P-420: Isolation and properties of cytochrome P-420

1978 • 8 citations

Kinetic and spectral studies of type I and type II compounds with rat hepatic microsomes in the presence of the major metabolite of diphenylhydantoin.

1975 • 8 citations

Substrate Interaction with P-450 and Drug Hydroxylation by Liver Microsomes of Rats under Physiologically Abnormal States

1969 • 7 citations

Enflurane and methoxyflurane: Their interaction with hepatic microsomal stearate desaturase

1980 • 5 citations

Further Studies on the P-450 Difference Spectra induced by Various Compounds in Liver Microsomes from 3-Methylcholanthrene Treated Rats

1973 • 3 citations

INFLUENCE OF SUBSTRATES OF HEPATIC MIXED FUNCTION OXIDASES ON SPIN EQUILIBRIUM OF CYTOCHROME P-450

1980 • 3 citations

THE ROLES OF MEMBRANE AND SUBSTRATES IN THE MODULATION OF CYTOCHROME P-450 FUNCTION

1980 • 1 citations