The Role of Endotoxin in Liver Injury

Renal failure in the patient with cirrhosis

1970 • 458 citations

Influences of Dietary and Environmental Stress on Microbial Populations in the Murine Gastrointestinal Tract

1974 • 343 citations

Changes in the Blood Coagulation System Associated with Septicemia

1968 • 318 citations

The problem of chronic liver disease in young women

1956 • 299 citations

CHARCOAL HÆMOPERFUSION IN THE TREATMENT OF FULMINANT HEPATIC FAILURE

1974 • 269 citations

Protection Against Enteric Bacterial Infection by Secretory IgA Antibodies

1973 • 263 citations

TOLERANCE TO BACTERIAL PYROGENS

1947 • 262 citations

ON THE ABSORPTION OF BACTERIAL ENDOTOXIN FROM THE GASTRO-INTESTINAL TRACT OF THE NORMAL AND SHOCKED ANIMAL

1960 • 229 citations

PATHOGENESIS OF EXPERIMENTAL SHOCK

1962 • 226 citations

BACTERIAL AND DIETARY ANTIBODIES IN LIVER DISEASE

1972 • 224 citations

RELATION OF RENAL IMPAIRMENT AND HAEMORRHAGIC DIATHESIS TO ENDOTOXAEMIA IN FULMINANT HEPATIC FAILURE

1974 • 213 citations

Immunization with R mutants of S. Minnesota. I. Protection against challenge with heterologous gram-negative bacilli.

1972 • 197 citations

ANTIBODIES TO INTESTINAL MICROBES IN SERUM OF PATIENTS WITH CIRRHOSIS OF THE LIVER

1972 • 191 citations

RENAL AND INTRARENAL BLOOD-FLOW IN CIRRHOSIS OF THE LIVER

1971 • 174 citations

The bacterial content of the small intestine in normal and cirrhotic subjects: relation to methionine toxicity.

1957 • 170 citations

Evidence for a Common Hapten Associated with Endotoxin Fractions of E. coli and other Enterobacteriaceae.

1962 • 159 citations

Passive Immunization against the Local Shwartzman Reaction

1972 • 142 citations

ROLE OF THE LIVER IN CONTROLLING THE IMMUNOGENICITY OF COMMENSAL BACTERIA IN THE GUT

1973 • 121 citations

Herpesvirus hominis Infection in Newborn Mice. I. An Experimental Model and Therapy with Iododeoxyuridine

1973 • 115 citations

Effect of Endotoxemia on Liver Cell Mitochondria in Man

1970 • 108 citations

THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS

1957 • 108 citations

Hyperlipidemia, fatty liver, and bromsulfo-phthalein retention in rabbits injected intravenously with bacterial endotoxins

1964 • 106 citations

Endotoxin and Acute Renal Failure Associated with Obstructive Jaundice

1970 • 104 citations

INFLUENCE OF NEOMYCIN AND INGESTED ENDOTOXIN IN THE PATHOGENESIS OF CHOLINE DEFICIENCY CIRRHOSIS IN THE ADULT RAT

1964 • 101 citations

Alcohol induced depression of reticuloendothelial function in the rat.

1967 • 97 citations

Immunization with R Mutants of S. Minnesota

1972 • 90 citations

Effect of endotoxin on capillary permeability to macromolecules

1964 • 74 citations

HOST DEFENSE AGAINST BACTERIAL ENDOTOXEMIA: MECHANISM IN NORMAL ANIMALS

1970 • 71 citations

ANTI-SALMONELLA AGGLUTININS IN CHRONIC ACTIVE LIVER DISEASE

1971 • 70 citations

Role of the Intestinal Flora in Major Trauma

1973 • 67 citations

Hepatic changes produced by a single dose of endotoxin in the mouse. Electron microscopy.

1968 • 65 citations

Hemodynamic changes in endotoxin shock

1966 • 61 citations

Toward an Artificial Liver

1974 • 57 citations

THE ESSENTIAL ROLE OF THE LIVER IN DETOXIFICATION OF ENDOTOXIN

1966 • 55 citations

THE ROLE OF ENDOTOXIN DURING TYPHOID FEVER AND TULAREMIA IN MAN. I. ACQUISITION OF TOLERANCE TO ENDOTOXIN*

1963 • 53 citations

GERMFREE ANIMALS AND LIVER NECROSIS

1954 • 51 citations

Endotoxin and the Liver. I. Toxicity in Rats with Choline Deficient Fatty Livers

1968 • 51 citations

IN VIVO DETOXIFICATION OF ENDOTOXIN BY THE RETICULOENDOTHELIAL SYSTEM

1960 • 51 citations

Intestinal Microflora in Patients with Alcoholic Cirrhosis: Urea-Splitting Bacteria and Neomycin Resistance

1972 • 50 citations

Endotoxin and the liver. II. Effect of tolerance on carbon tetrachloride-induced injury.

1973 • 48 citations

Experimental Shigella Infections. III. Sensitivity of Normal, Starved and Carbon Tetrachloride Treated Guinea Pigs to Endotoxin

1960 • 48 citations

Some metabolic and nutritional studies with germfree animals.

1963 • 48 citations

Comparative Response of Normal and Cirrhotic Rats to Intravenously Injected Bacteria.

1959 • 47 citations

Qualitative and Quantitative Relationships of the Fecal Flora in Cirrhotic Patients with Portal Systemic Encephalopathy and Following Portacaval Anastomosis

1970 • 47 citations

Endotoxin Binding by Charged and Uncharged Resins

1975 • 46 citations

Effect of cholestyramine on endotoxin toxicity and absorption

1972 • 46 citations

Demonstration of a lethal endotoxemia in experimental occlusion of the superior mesenteric artery.

1971 • 44 citations

Production of Fatal Endotoxic Shock by Vasoactive Substances

1973 • 44 citations

The fever of Laennec's cirrhosis.

1960 • 44 citations

Effects of endotoxin on renal function and hemodynamics

1963 • 42 citations

ANTIBIOTICS AND LIVER INJURY

1954 • 40 citations

Sulfonamide Drugs as Protective Agents Against Carbon Tetrachloride Poisoning.

1941 • 36 citations

Antibodies to Escherichia Coli in Alcoholic and Non-Alcoholic Patients with Cirrhosis of the Liver or Fatty Liver

1973 • 35 citations

Mechanisms of endotoxin tolerance. VII. The role of the liver.

1970 • 33 citations

Reticuloendothelial dysfunction and endotoxemia following protal vein occlusion.

1974 • 33 citations

Experimental endotoxin shock

1962 • 32 citations

Effect of Cortisone on Response to Endotoxin in Mature Rabbits

1954 • 30 citations

Homologous and Heterologous Resistance in Mice Given Bacterial Endotoxins

1957 • 30 citations

Host Defense Against Bacterial Endotoxemia-Contribution of The Early and Late Components of Complement to Detoxification

1972 • 30 citations

Effect of Antibiotics, Sulfonamides, and a Nitrofuran on Development of Hepatic Cirrhosis in Choline-Deficient Rats

1962 • 28 citations

Studies on the Absorption of Escherichia Coli Endotoxin from the Gastrointestinal Tract of Dogs in the Pathogenesis of “Irreversible” Hemorrhagic Shock1

1958 • 28 citations

EFFECT OF NUTRITION ON THE RESISTANCE OF MICE TO ENDOTOXIN AND ON THE BACTERICIDAL POWER OF THEIR TISSUES

1959 • 27 citations

Effect of Route of Administration on Protective Action of Corticosterone and Cortisol Against Endotoxin

1956 • 26 citations

VASCULAR RESPONSE IN THE ISOLATED RAT LIVER

1965 • 25 citations

Effect of Endotoxins on Phagocytic Activity of the Reticuloendothelial System of the Rat

1963 • 25 citations

Endotoxemia in the Rhesus Monkey: Alterations in Host Lipid and Carbohydrate Metabolism

1974 • 24 citations

Late effect of estrogen on endotoxin response in the rat.

1968 • 23 citations

Function of the Reticuloendothelial System in Experimental Shock and Combined Injury

1969 • 22 citations

Mechanisms of Endotoxin Tolerance

1970 • 22 citations

Protective effect of cysteine and methylprednisolone in lead acetate-endotoxin induced shock

1973 • 21 citations

Experimental giant-cell transformation in the liver induced by E. coli endotoxin.

1967 • 20 citations

Influence of Carbon Tetrachloride on Inducible Liver Enzymes and Response to Endotoxin in Mice

1967 • 19 citations

Early alterations in mitochondrial membrane transport during endotoxemia

1974 • 19 citations

Susceptibility of Rabbits to Pyrogenic and Lethal Effects of Endotoxin after Acute Liver Injury

1968 • 16 citations

Serial assessment of reticuloendothelial function in experimentally induced nutritional cirrhosis.

1969 • 15 citations

Influence of diethylstilbestrol (DES) on reticuloendothelial function, tissue distribution, and detoxication of S. enteritidis endotoxin.

1972 • 13 citations

Cardiovascular and Metabolic Effects of Whole or Fractionated Gram-Negative Bacterial Endotoxin in the Unanesthetized Rhesus Monkey

1973 • 13 citations

Septicemia as a manifestation of acute liver failure.

1971 • 13 citations

Changes in Total Peripheral Resistance in Endotoxin Shock.

1961 • 13 citations

Renal blood flow during endotoxin shock in the subhuman primate.

1973 • 12 citations

The effect of estrogen on the liver in murine viral hepatitis.

1963 • 11 citations

Hepatic damage by reticuloendothelial interference.

1963 • 11 citations

DEPRESSION OF ISOLATED HEART MUSCLE BY BACTERIAL ENDOTOXIN

1973 • 11 citations

Stability of Escherichia coli endotoxin in the rat gastro‐intestinal tract

1968 • 10 citations

Endotoxin-Induced Inhibition of Renal Function in the Mouse

1968 • 10 citations

Successful induction of increased resistance to gram-negative bacteria and to endotoxin in immunosuppressed mice

1974 • 8 citations

Sulfaguanidine protection of mouse liver from carbon tetrachloride-induced necrosis.

1973 • 8 citations

Hemodynamic, Biochemical and Coagulation Alterations in Endotoxin Shock

1968 • 6 citations

Early hepatic and extrahepatic pooling in response to endotoxin

1970 • 5 citations