The first EGF-like domain from human factor IX contains a high-affinity calcium binding site.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Transformation of yeast.

1978 • 2,267 citations

Transformation of yeast by a replicating hybrid plasmid

1978 • 1,362 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae.

1984 • 477 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

1987 • 399 citations

The gene structure of human anti-haemophilic factor IX.

1984 • 361 citations

Efficient synthesis of enzymatically active calf chymosin in Saccharomyces cerevisiae

1983 • 337 citations

The solution structure of human epidermal growth factor

1987 • 322 citations

The role of beta-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX.

1988 • 240 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C.

1983 • 202 citations

Molecular pathology of haemophilia B.

1989 • 178 citations

Beta-hydroxyaspartic acid in vitamin K-dependent proteins.

1983 • 163 citations

Prothrombin requires two sequential metal-dependent conformational transitions to bind phospholipid. Conformation-specific antibodies directed against the phospholipid-binding site on prothrombin.

1986 • 124 citations

Calcium binding to the isolated β-hydroxyaspartic acid-containing epidermal growth factor-like domain of bovine factor X

1989 • 109 citations

Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid.

1984 • 101 citations

Calcium binding to the epidermal growth factor homology region of bovine protein C.

1988 • 99 citations

Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region.

1984 • 96 citations

Calcium-dependent interaction between the epidermal growth factor precursor-like region of human protein C and a monoclonal antibody.

1987 • 65 citations

Factor IXAlabama: a point mutation in a clotting protein results in hemophilia B

1987 • 60 citations

The factor IX phospholipid-binding site is required for calcium-dependent activation of factor IX by factor XIa.

1987 • 59 citations

Calcium binding of bovine protein S. Effect of thrombin cleavage and removal of the gamma-carboxyglutamic acid-containing region.

1986 • 54 citations

Calcium binding to a human factor IXa derivative lacking γ-carboxyglutamic acid: Evidence for two high-affinity sites that do not involve β-hydroxyaspartic acid

1985 • 46 citations

Disulphide bridges of bovine factor X

1987 • 40 citations

Calcium binding and putative activity of the epidermal growth factor domain of blood coagulation Factor IX

1989 • 36 citations