Fibroblast Growth Factors

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Structural Characterization and Biological Functions of Fibroblast Growth Factor

1987 • 1,299 citations

Anti-Angiogenesis

1972 • 1,167 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells

1985 • 911 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

1986 • 870 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

1974 • 786 citations

Long-term culture of capillary endothelial cells.

1979 • 780 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

1985 • 710 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor.

1984 • 624 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Purification of a fibroblast growth factor from bovine pituitary.

1975 • 595 citations

A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro.

1976 • 579 citations

Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.

1990 • 533 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 • 495 citations

Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.

1987 • 480 citations

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

1989 • 469 citations

Purification of proteins by IMAC

1985 • 435 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Clonal growth of bovine vascular endothelial cells: fibroblast growth factor as a survival agent.

1976 • 423 citations

Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition.

1987 • 422 citations

Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells invitro: Implications for a role of heparinase-like enzymes in the neovascular response

1987 • 416 citations

Pituitary Extracts and Steroid Hormones in the Control of 3T3 Cell Growth

1973 • 387 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds

1988 • 382 citations

Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity

1986 • 380 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence

1990 • 373 citations

Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor

1985 • 372 citations

Fibroblast growth factor

1986 • 367 citations

The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm Inducer

1988 • 367 citations

Fibroblast growth factors promote the survival of adult rat retinal ganglion cells after transection of the optic nerve

1987 • 355 citations

Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration.

1986 • 354 citations

The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells.

1985 • 352 citations

Heparan Sulfate Degradation: Relation to Tumor Invasive and Metastatic Properties of Mouse B16 Melanoma Sublines

1983 • 350 citations

Basement Membrane Collagen: Degradation by Migrating Endothelial Cells

1983 • 345 citations

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

1986 • 340 citations

Molecular Characterization of Fibroblast Growth Factor: Distribution and Biological Activities in Various Tissues

1986 • 340 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Brain-Derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies

1985 • 335 citations

Nuclear and cytoplasmic localization of different basic fibroblast growth factor species

1990 • 332 citations

Receptor- and heparin-binding domains of basic fibroblast growth factor.

1988 • 318 citations

Transforming growth factor-beta inhibits endothelial cell proliferation

1986 • 313 citations

Inhibition of endothelial cell proliferation by type β-transforming growth factor: Interactions with acidic and basic fibroblast growth factors

1986 • 312 citations

An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes

1989 • 305 citations

Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography

1984 • 298 citations

Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1.

1985 • 294 citations

Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

1989 • 294 citations

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

1987 • 293 citations

Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon

1990 • 293 citations

Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts

1986 • 285 citations

Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia

1987 • 285 citations

Human endothelial cells are chemotactic to endothelial cell growth factor and heparin.

1985 • 282 citations

Purification of heparin-binding growth factors

1986 • 279 citations

Site-Directed Neovessel Formation in Vivo

1988 • 278 citations

Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells.

1988 • 276 citations

Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor.

1990 • 274 citations

Fibroblast growth factors

1987 • 273 citations

Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration.

1986 • 272 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Retina- and eye-derived endothelial cell growth factors: partial molecular characterization and identity with acidic and basic fibroblast growth factors

1985 • 268 citations

Growth of purified astrocytes in a chemically defined medium.

1981 • 268 citations

Purification and characterization of acidic fibroblast growth factor from bovine brain.

1984 • 267 citations

Regulation of Bovine Bone Cell Proliferation by Fibroblast Growth Factor and Transforming Growth Factorβ

1988 • 264 citations

Purification and characterization of heparin-binding endothelial cell growth factors.

1986 • 263 citations

The angiogenic activity of the fibroblast and epidermal growth factor

1979 • 261 citations

Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

1988 • 261 citations

Corpus Luteum Angiogenic Factor Is Related to Fibroblast Growth Factor*

1985 • 260 citations

bFGF is the putative natural growth factor for human melanocytes

1987 • 259 citations

Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis.

1983 • 259 citations

Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo

1988 • 255 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

Both normal and tumor cells produce basic fibroblast growth factor

1986 • 250 citations

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

1987 • 247 citations

Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor.

1986 • 247 citations

Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers.

1987 • 239 citations

bFGF as an autocrine growth factor for human melanomas.

1988 • 237 citations

Purification of two astroglial growth factors from bovine brain

1985 • 235 citations

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.

1986 • 234 citations

Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet‐derived growth factor‐like protein which is secreted

1987 • 229 citations

Fibroblast growth factor is a mitogen for oligodendrocytes in vitro

1985 • 227 citations

Ceruloplasmin, Copper Ions, and Angiogenesis<xref ref-type="fn" rid="fn2">2</xref>

1982 • 226 citations

Isolation and partial molecular characterization of pituitary fibroblast growth factor.

1984 • 225 citations

Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities.

1984 • 224 citations

Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilage-derived growth factor.

1985 • 221 citations

Primary structure of bovine brain acidic fibroblast growth factor (FGF)

1985 • 213 citations

Multiple influences of a heparin-binding growth factor on neuronal development.

1987 • 212 citations

The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle

1943 • 212 citations

Fibroblast Growth Factor and Transforming Growth Factor β Repress Transcription of the Myogenic Regulatory Gene MyoD1

1989 • 212 citations

Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system

1990 • 212 citations

Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.

1985 • 210 citations

Complementary DNA cloning and sequencing of rat ovarian basic fibroblast growth factor and tissue distribution study of its mRNA

1988 • 210 citations

Characterization of cultured rat oligodendrocytes proliferating in a serum-free, chemically defined medium.

1985 • 205 citations

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

1989 • 203 citations

Fibroblast growth factors

1989 • 202 citations

Factors regulating ovarian function

1983 • 202 citations

Control of Bovine Adrenal Cortical Cell Proliferation by Fibroblast Growth Factor. Lack of Effect of Epidermal Growth Factor

1977 • 201 citations

Pituitary follicular cells produce basic fibroblast growth factor.

1987 • 200 citations

An alternative approach to somatic cell gene therapy.

1988 • 198 citations

Cell surface fibroblast growth factor and epidermal growth factor receptors are permanently lost during skeletal muscle terminal differentiation in culture.

1988 • 197 citations

Hormones and growth factors induce the synthesis of glial fibrillary acidic protein in rat brain astrocytes

1985 • 195 citations

Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).

1987 • 194 citations

Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints.

1990 • 185 citations

Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.

1988 • 181 citations

Induction of angiogenesis by bovine brain derived class 1 heparin-binding growth factor

1985 • 180 citations

Sulfated proteoglycan synthesis by confluent cultures of rabbit costal chondrocytes grown in the presence of fibroblast growth factor.

1985 • 179 citations

Acidic fibroblast growth factor (FGF) from bovine brain: amino-terminal sequence and comparison with basic FGF.

1985 • 178 citations

The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts.

1986 • 178 citations

Bovine Granulosa Cells Produce Basic Fibroblast Growth Factor*

1987 • 175 citations

Production a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum.

1978 • 174 citations

Basic fibroblast growth factor in Alzheimer's disease

1990 • 173 citations

Stimulation of Growth of Keratinocytes by Basic Fibroblast Growth Factor

1988 • 172 citations

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential.

1988 • 171 citations

Control by fibroblast growth factor of differentiation in the BC3H1 muscle cell line.

1985 • 166 citations

Heparin modulation of the neurotropic effects of acidic and basic fibroblast growth factors and nerve growth factor on PC12 cells

1987 • 163 citations

Peptides: Integrators of Cell and Tissue Function

1981 • 156 citations

Angiogenic activity from bovine retina: partial purification and characterization.

1981 • 154 citations

Stabilizing basic fibroblast growth factor using protein engineering

1988 • 153 citations

An angiogenic growth factor is expressed in human glioma cells.

1987 • 152 citations

Association of bovine brain-derived growth factor receptor with protein tyrosine kinase activity.

1986 • 151 citations

Heparin protects heparin-binding growth factor-I from proteolytic inactivation in vitro

1988 • 149 citations

Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells.

1988 • 149 citations

Induction of protein kinase C activation and Ca²⁺ mobilization by fibroblast growth factor in Swiss 3T3 cells

1985 • 148 citations

Increased levels of fibroblast growth factor-like activity in urine from patients with bladder or kidney cancer.

1988 • 146 citations

Control of mouse myoblast commitment to terminal differentiation by mitogens

1980 • 146 citations

Isolation of Fibroblast Growth Factor from Bovine Adrenal Gland: Physicochemical and Biological Characterization*

1986 • 145 citations

Developing brain produces an angiogenesis factor.

1986 • 143 citations

High and low molecular weight forms of endothelial cell growth factor.

1982 • 140 citations

Mitogens for glial cells: a comparison of the response of cultured astrocytes, oligodendrocytes and schwann cells

1981 • 137 citations

Regulation of skeletal muscle satellite cell proliferation by bovine pituitary fibroblast growth factor

1984 • 136 citations

A nonmitogenic pituitary function of fibroblast growth factor: regulation of thyrotropin and prolactin secretion.

1985 • 135 citations

Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.

1987 • 134 citations

Fibroblast growth factor effects on peripheral nerve regeneration in a silicone chamber model

1988 • 133 citations

Neurite outgrowth induced by an endothelial cell mitogen isolated from retina.

1986 • 131 citations

Expression of basic fibroblast growth factor in the nervous system of early avian embryos

1990 • 128 citations

Isolation of pituitary fibroblast growth factor by fast protein liquid chromatography (FPLC): Partial chemical and biological characterization

1985 • 128 citations

Evidence that fibroblast growth factor promotes lens fibre differentiation

1987 • 127 citations

Activation of guanyl cyclase and intracellular cyclic GMP by fibroblast growth factor

1974 • 125 citations

Hormonal Control of Adrenocortical Cell Proliferation

1977 • 124 citations

An in vivo model for study of the angiogenic effects of basic fibroblast growth factor

1987 • 123 citations

Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor.

1986 • 121 citations

General Endocrinology.

1966 • 118 citations

Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.

1987 • 117 citations

Modulation of the sis Gene Transcript During Endothelial Cell Differentiation in Vitro

1985 • 117 citations

Porcine follistatin gene structure supports two forms of mature follistatin produced by alternative splicing

1988 • 117 citations

Human brain-derived acidic and basic fibroblast growth factors: Amino terminal sequences and specific mitogenic activities

1986 • 112 citations

Glycosylation of the basic fibroblast growth factor receptor. The contribution of carbohydrate to receptor function.

1988 • 112 citations

The characterization of the receptor for endothelial cell growth factor by covalent ligand attachment.

1986 • 111 citations

Initiation of Angiogenesis by Human Follicular Fluid

1984 • 111 citations

Is There a Ubiquitous Growth Factor in the Eye?

1981 • 111 citations

A form of human basic fibroblast growth factor with an extended amino terminus

1987 • 110 citations

Vascular endothelial cells maintained in the absence of fibroblast growth factor undergo structural and functional alterations that are incompatible with their in vivo differentiated properties.

1979 • 108 citations

Growth Stimulation of Rat Calvaria Osteoblastic Cells by Acidic Fibroblast Growth Factor

1987 • 106 citations

Production of a heparin-binding angiogenesis factor by the embryonic kidney.

1986 • 105 citations

Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells.

1986 • 105 citations

Effects of aFGF and bFGF on wound healing in rabbit corneas

1987 • 103 citations

Brain fibroblast growth factor: nonidentity with myelin basic protein fragments.

1980 • 102 citations

Nucleotide sequence of rat basic fibroblast growth factor cDNA

1988 • 99 citations

Control of myogenic differentiation by fibroblast growth factor is mediated by position in the G1 phase of the cell cycle.

1985 • 99 citations

Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein.

1988 • 98 citations

Fibroblast growth factor levels in the whole embryo and limb bud during chick development

1988 • 97 citations

Basic fibroblast growth factor as a regulator of ovarian granulosa cell differentiation: a novel non-mitogenic role

1988 • 97 citations

Characterization of acidic and basic fibroblast growth factors in brain, retina and vitreous chick embryo

1987 • 96 citations

Fibroblast growth factor treatment of Swiss 3T3 cells activates a subunit S6 kinase that phosphorylates a synthetic peptide substrate.

1986 • 96 citations

Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury

1988 • 94 citations

Isolation and partial characterization of basic fibroblast growth factor from bovine testis

1987 • 93 citations

Isolation and partial characterization of an endothelial cell growth factor from the bovine kidney: homology with basic fibroblast growth factor

1985 • 93 citations

Expression of the K-fgf proto-oncogene is controlled by 3' regulatory elements which are specific for embryonal carcinoma cells.

1990 • 93 citations

Involvement of three intracellular messenger systems, protein kinase C, calcium ion and cyclic AMP, in the regulation of c‐fos gene expression in Swiss 3T3 cells

1986 • 90 citations

Fibroblast growth factor stimulates colony formation of differentiated chondrocytes in soft agar

1987 • 89 citations

Isolation of a Receptor for Acidic and Basic Fibroblast Growth Factor from Embryonic Chick

1989 • 88 citations

Fibroblast growth factor as an intraovarian hormone: differential regulation of steroidogenesis by an angiogenic factor

1986 • 86 citations

Myogenic growth factor present in skeletal muscle is purified by heparin-affinity chromatography.

1985 • 86 citations

The complete amino acid sequence of human brain-derived acidic fibroblast growth factor

1986 • 85 citations

Effect of heparin on the stimulation of non-vascular cells by human acidic and basic FGF

1986 • 83 citations

Growth requirements of low‐density rabbit costal chondrocyte cultures maintained in serum‐free medium

1984 • 83 citations

Expression and processing of biologically active fibroblast growth factors in the yeast Saccharomyces cerevisiae.

1988 • 81 citations

Purification of a cartilage-derived growth factor.

1980 • 81 citations

Human Basic Fibroblast Growth Factor: Nucleotide Sequence, Genomic Organization, and Expression in Mammalian Cells

1986 • 79 citations

The genes for basic and acidic fibroblast growth factors are on different human chromosomes

1986 • 78 citations

Enhancement of angiogenesis by bFGF in mandibular bone graft healing in the rabbit

1988 • 78 citations

Localization of acidic fibroblast growth factor in specific subcortical neuronal populations

1992 • 77 citations

Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor.

1988 • 77 citations

Sequential degradation of heparan sulfate in the subendothelial extracellular matrix by highly metastatic lymphoma cells

1985 • 75 citations

Effects of endothelial cell growth factor on bone remodelling in vitro.

1987 • 75 citations

Isolation of an amino terminal extended form of basic fibroblast growth factor

1986 • 74 citations

Endothelial Cell Growth Factors and the Vessel Wall

1987 • 73 citations

Circulating Fibroblast Growth Factor-Like Substance in Familial Multiple Endocrine Neoplasia Type 1*

1990 • 72 citations

Heparin binding affinity of rat prostatic growth factor in normal and cancerous prostates: partial purification and characterization of rat prostatic growth factor in the Dunning tumor.

1987 • 71 citations

Intracrine regulation at the nucleus–a further mechanism of growth factor activity?

1990 • 71 citations

Immunoreactive fibroblast growth factor (FGF) in rat tissues: Molecular weight forms and the effects of hypophysectomy

1985 • 71 citations

Bovine brain-derived growth factor. Purification and characterization of its interaction with responsive cells.

1986 • 69 citations

Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue

1987 • 69 citations

Acidic fibroblast growth factor is present in nonneural tissue: isolation and chemical characterization from bovine kidney

1987 • 69 citations

Induction of mesodermal tissues by acidic and basic heparin binding growth factors

1988 • 68 citations

Basic fibroblast growth factor as a growth inhibitor for cultured human tumor cells.

1987 • 68 citations

Evidence for a Role of Basic Fibroblast Growth Factor in Rat Embryonic Growth and Differentiation*

1988 • 67 citations

The isolation and purification of two anionic endothelial cell growth factors from human brain

1984 • 66 citations

Comparison of the effects of EGF, pFGF and EDGF on corneal epithelium wound healing

1984 • 66 citations

Basic Fibroblast Growth Factor: Production and Growth Stimulation in Cultured Adrenal Cortex Cells*

1987 • 66 citations

Morphological and biochemical maturation of rat astroglial cells grown in a chemically defined medium: Influence of an astroglial growth factor

1985 • 64 citations

Biological equivalence of natural bovine and recombinant human alpha-endothelial cell growth factors.

1987 • 63 citations

Mitogenic effect of a growth factor derived from myelin on denervated regenerates of newt forelimbs

1979 • 63 citations

Purification of basic FGF receptors from rat brain

1988 • 63 citations

Studies on the Growth of Tissues in Vitro

1939 • 63 citations

Reductive methylation of lysine residues in acidic fibroblast growth factor: effect on mitogenic activity and heparin affinity

1988 • 60 citations

Stimulation of wound healing, using brain extract with fibroblast growth factor (PGF) activity

1982 • 60 citations

Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells

1988 • 58 citations

Cell Proliferation in the Mammalian Testis: Biology of the Seminiferous Growth Factor (SGF)

1984 • 57 citations

Purification of basic fibroblast growth factor from rat brain: Identification of a Mr 22,000 immunoreactive form

1988 • 57 citations

Fibroblast Growth Factor Inhibits Luteinizing Hormone-Stimulated Androgen Production by Cultured Rat Testicular Cells*

1988 • 57 citations

Purification and partial characterization of an acidic fibroblast growth factor from bovine pituitary.

1982 • 56 citations

Superinduction by cycloheximide of mitogen‐induced secreted proteins produced by Balb/c 3T3 cells

1985 • 55 citations

Growth stimulation of human breast epithelial cells by basic fibroblast growth factor in serum‐free medium

1989 • 55 citations

Differential effects of heparin, fibronectin, and laminin on the phosphorylation of basic fibroblast growth factor by protein kinase C and the catalytic subunit of protein kinase A.

1989 • 55 citations

The Nonluteal Porcine Ovary as a Source of Angiogenic Activity*

1984 • 53 citations

Characterization of multiple forms of prostatropin (prostate epithelial cell growth factor) from bovine brain

1986 • 51 citations

Fibroblast growth factor induces the soft agar growth of two non-transformed celllines

1986 • 50 citations

Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1.

1990 • 50 citations

Fibroblast Growth Factor Modulates Synthesis of Collagen in Cultured Vascular Endothelial Cells

1982 • 50 citations

Transforming potential of fibroblast growth factor genes

1988 • 50 citations

The FGF-related oncogenes hst and int.2, and the bcl.1 locus are contained within one megabase in band q13 of chromosome 11, while the fgf.5 oncogene maps to 4q21.

1988 • 49 citations

Isolation and characterization of different molecular and chromatographic forms of heparin-binding growth factor 1 from bovine brain

1987 • 49 citations

Appearance of basic fibroblast growth factor receptors upon differentiation of rat mammary epithelial to myoepithelial‐like cells in culture

1990 • 47 citations

Humoral control of cell proliferation: the role of fibroblast growth factor in regeneration, angiogenesis, wound healing, and neoplastic growth.

1976 • 46 citations

The effects of epidermal and fibroblast growth factors on the repair of corneal endothelial wounds in bovine corneas maintained in organ culture

1979 • 46 citations

Radioimmunoassay for fibroblast growth factor (FGF): release by the bovine anterior pituitary in vitro

1985 • 45 citations

Immunoreactive fibroblast growth factor (FGF) in a transplantable chondrosarcoma: Inhibition of tumor growth by antibodies to FGF

1986 • 45 citations

Purification and partial characterization of bovine pituitary fibroblast growth factor

1983 • 45 citations

Evidence for FGF-like growth factor in adult bovine retina: Analogies with EDGF I

1986 • 45 citations

Synthesis of basic fibroblast growth factor upon differentiation of rat mammary epithelial to myoepithelial‐like cells in culture

1990 • 44 citations

The effect of an Eye Derived Growth Factor (EDGF) on corneal epithelial regeneration

1982 • 44 citations

Chapter 42 Trophic effects of fibroblast growth factor on neural tissue

1988 • 44 citations

Newt forelimb regeneration blastemas in vitro: Cellular response to explantation and effects of various growth‐promoting substances

1981 • 43 citations

Brain-derived growth factor is a chemoattractant for fibroblasts and astroglial cells

1986 • 41 citations

Stimulation of aromatase activity in immature porcine Leydig cells by fibroblast growth factor (FGF)

1988 • 41 citations

Eye-Derived Growth Factor Isolated from Bovine Retina and Used for Epidermal Wound Healing In Vivo

1986 • 39 citations

The development of a quantitative RIA for basic fibroblast growth factor using polyclonal antibodies against the 157 amino acid form of human bFGF

1988 • 39 citations

Growth Factors With Heparin Binding Affinity In Human Synovial Fluid

1987 • 39 citations

An amino-terminally extended and post-translationally modified form of a 25kD basic fibroblast growth factor

1989 • 38 citations

The Angiogenic Properties of the Rat Vibrissa Hair Follicle Associate with the Bulb

1988 • 38 citations

Heparin-copper biaffinity chromatography of fibroblast growth factors.

1988 • 38 citations

An eye-derived growth factor regulates epithelial cell proliferation in the cultured lens

1985 • 35 citations

Fibroblast growth factor induces a transient net K+ influx carried by the bumetanide-sensitive transporter in quiescent BALB/c 3T3 fibroblasts

1986 • 35 citations

The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2.

1988 • 32 citations

Antibodies against basic fibroblast growth factor inhibit the autocrine growth of pulmonary artery endothelial cells

1988 • 32 citations

Lens regeneration from cultured newt irises stimulated by retina-derived growth factors (EDGFs)

1986 • 32 citations

Biochemical comparative studies between eye- and brain-derived growth factors

1987 • 31 citations

Stimulation of wound healing, using brain extract with fibroblast growth factor (FGF) activity

1984 • 30 citations

Purification and characterization of a human mammary tumor-derived growth factor.

1986 • 29 citations

Primary structure of ovine pituitary basic fibroblast growth factor

1987 • 28 citations

Glycosaminoglycan production in cultures of early and late passage human endothelial cells: The influence of an anionic endothelial cell growth factor and the extracellular matrix

1985 • 28 citations

Decrease in the density of orthogonal arrays of particles in membranes of cultured rat astroglial cells by the brain fibroblast growth factor

1986 • 27 citations

Heparin-binding growth factor-I (endothelial cell growth factor) binds to endothelium in vivo

1988 • 27 citations

A bovine brain fraction with fibroblast growth factor activity inducing articular cartilage regeneration in vivo.

1980 • 27 citations

Influence of fibroblast growth factor on phosphorylation and activity of a 34 kDa lipocortin‐like protein in bovine epithelial lens cells

1988 • 26 citations

Estrogens, Cyclic Adenosine 3′,5′-Monophosphate, and Phorbol Esters Modulate the Prolactin Response of GH₃Cells to Basic Fibroblast Growth Factor*

1988 • 26 citations

Endothelial cell growth factor and ionophore A23187 stimulation of production of inositol phosphates in porcine aorta endothelial cells.

1988 • 26 citations

Capillary endothelial cell migration: loss of stress fibres in response to retina-derived growth factor

1984 • 25 citations

Amino acid sequence of human acidic fibroblast growth factor

1986 • 25 citations

Neuron localization and neuroblastoma cell expression of brain-derived growth factor

1987 • 24 citations

Presence of heparin binding growth factor in mouse bladder tumors and urine from mice with bladder cancer.

1986 • 23 citations

Lysates of two established human tumor lines contain heparin-binding growth factors related to bovine acidic brain fibroblast growth factor

1986 • 21 citations

Fibroblast growth factor and vertebrate regeneration.

1981 • 21 citations

The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon

1990 • 20 citations

Rapid enzymatic degradation of [125I] (Tyr 10) FGF (1–10) by serum in vitro and involvement in the determination of circulating FGF by RIA

1987 • 20 citations

Purification and partial characterization of a mitogenic factor from bovine liver: structural homology with basic fibroblast growth factor

1986 • 19 citations

Isolation, characterisation and tissue localisation of an N-terminal-truncated variant of fibroblast growth factor

1987 • 19 citations

Enhancement of fibroblast growth factor‐induced diacylglycerol formation and protein kinase C activation by colon tumor‐promoting bile acid in Swiss 3T3 cells

1986 • 18 citations

Differential Effects of Fibroblast Growth Factor on Insulin Receptor and Muscle Specific Protein Gene Expression in BC3H-1 Myocytes

1990 • 18 citations

Chemical and biological characterization of a truncated form of acidic fibroblast growth factor from bovine brain

1986 • 16 citations

The human basic fibroblast growth factor gene (FGFB) is assigned to chromosome 4q25

1990 • 16 citations

Acidic heparin binding growth factor transiently activates adenylate cyclase activity in human adult arterial smooth muscle cells

1987 • 15 citations

Electrophoresis of glycosaminoglycans isolated from normal human plasma. Direct evidence for the presence of a heparin-like molecule.

1987 • 14 citations

Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors

1986 • 13 citations

Induction of c-fos, Calcitonin Gene Expression, and Acidic Fibroblast Growth Factor Production in a Multipeptide-Secreting Neuroendocrine Cell Line*

1988 • 13 citations

Transforming growth factor activity of bovine brain-derived growth factor

1986 • 12 citations

Structural changes induced in capillary endothelial cells by growth factors: Altered distribution of cytoskeletal elements and organelles in cells spreading in the presence of tumor conditioned medium and hypothalamus derived growth factor

1986 • 11 citations

Characterization of the growth responses of hamster fibroblasts and chondrogenic cells to fibroblast growth factor

1984 • 10 citations

Effect of heparin-binding growth factors on monovalent cation transport in Balb/C 3T3 cells

1987 • 9 citations

Induction and Suppression of Type I Collagenase in Cultured Human Cells

1987 • 9 citations

Electron microscopic observations on capillaries of atherosclerotic aorta.

1959 • 9 citations

Fibroblast Growth Factors as Local Mediators of Gonadal Function

1989 • 9 citations

[Use of the eye-derived growth factor in the treatment of ulcer of the cornea. A veterinary medicine study in the dog].

1985 • 4 citations

Basic fibroblast growth factor (bFGF) enhances retinal ganglion cells’ survival and promotes axonal growth of rat transected optic nerve

1989 • 4 citations

Regulation of protein metabolism and DNA synthesis by fibroblast growth factor in BHK-21 cells

1988 • 3 citations