Astrocytes as a primary locus for the conversion MPTP into MPP+

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

1984 • 1,005 citations

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1984 • 913 citations

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1984 • 575 citations

Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons.

1982 • 509 citations

Distinct Monoamine Oxidase A and B Populations in Primate Brain

1985 • 496 citations

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP

1984 • 313 citations

An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe nucleus to the substantia nigra in the rat

1977 • 210 citations

Advances in Biochemical Psychopharmacology vol 1.

1970 • 188 citations

The nucleus raphe dorsalis of the rat and its projection upon the caudatoputamen. A combined cytoarchitectonic, immunohistochemical and retrograde transport study.

1981 • 166 citations

High-Affinity Uptake of Serotonin Into Immunocytochemically Identified Astrocytes

1985 • 147 citations

Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum

1985 • 110 citations

Effect of 3-(p-trifluoromethylphenoxy). N. N. methyl-3-phenylpropylamine on the depletion of brain serotonin by 4-chloroamphetamine.

1975 • 100 citations

Chemical lesioning of central monoamine axons by means of 5,6-dihydroxytryptamine and 5,7-dihydroxytryptamine.

1974 • 82 citations

Age-dependent effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)

1985 • 78 citations

Occurrence and functional significance of serotonin and catecholamine uptake by astrocytes

1986 • 74 citations

Serotonergic conversion of MPTP and dopaminergic accumulation of MPP⁺

1985 • 38 citations

Serotonin neurotoxins: recent advances in the mode of administration and molecular mechanism of action.

1981 • 31 citations

Differential time course of protection by monoamine oxidase inhibition and uptake inhibition against MPTP neurotoxicity on central catecholamine neurons in mice

1986 • 25 citations

Tolerance following the repeated administration of high doses of phencyclidine: No relation to central catecholamine depletion

1984 • 17 citations

The neurotoxic actions of 1-methyl-4-phenylpyridine (MPP+) are not prevented by deprenyl treatment

1985 • 11 citations

Cocaine blocks the dopamine depletion induced by MPTP.

1985 • 7 citations