Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Cancer statistics, 2016

2016 • 15,590 citations

Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

2017 • 14,809 citations

Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer

2016 • 8,644 citations

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

2015 • 5,944 citations

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

2015 • 5,526 citations

Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria

2009 • 3,044 citations

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

2015 • 2,154 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Checking the Cox model with cumulative sums of martingale-based residuals

1993 • 1,343 citations

Overall Survival and Long-Term Safety of Nivolumab (Anti–Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer

2015 • 1,128 citations

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

2005 • 894 citations

Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy

2015 • 748 citations

Incidence of Programmed Cell Death 1 Inhibitor–Related Pneumonitis in Patients With Advanced Cancer

2016 • 636 citations

Role of Local Radiation Therapy in Cancer Immunotherapy

2015 • 631 citations

From Vaccines to Memory and Back

2010 • 578 citations

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1–Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

2014 • 578 citations

Radiotherapy Promotes Tumor-Specific Effector CD8+ T Cells via Dendritic Cell Activation

2012 • 396 citations

Current clinical trials testing the combination of immunotherapy with radiotherapy

2016 • 347 citations

Lung cancer epidemiology: contemporary and future challenges worldwide

2016 • 344 citations

Combining Radiation and Immunotherapy: A New Systemic Therapy for Solid Tumors?

2014 • 298 citations

Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

2012 • 270 citations

The Blood-Brain Barrier and Its Role in Immune Privilege in the Central Nervous System

2003 • 269 citations

In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment

2015 • 159 citations

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

2016 • 145 citations

T-Cell Responses to Survivin in Cancer Patients Undergoing Radiation Therapy

2008 • 140 citations

Ionizing Radiation Affects Human MART-1 Melanoma Antigen Processing and Presentation by Dendritic Cells

2004 • 114 citations

Apoptotic, necrotic, or fused tumor cells: An equivalent source of antigen for dendritic cell loading

2006 • 46 citations

Fractionated radiotherapy combined with PD-1 pathway blockade promotes CD8 T cell-mediated tumor clearance for the treatment of advanced malignancies.

2016 • 13 citations