Developmental changes predispose the fetal thymus to positive selection of CD4+CD8- T cells.

A rapid method for the isolation of functional thymus‐derived murine lymphocytes

1973 • 4,203 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Selective Events in T Cell Development

1994 • 486 citations

Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments

1982 • 324 citations

TISSUE INTERACTION IN THE DEVELOPMENT OF THYMUS LYMPHOCYTES

1969 • 295 citations

Studies on T cell maturation on defined thymic stromal cell populations in vitro.

1992 • 249 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

A single stem cell can recolonize an embryonic thymus, producing phenotypically distinct T-cell populations

1985 • 199 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.

1991 • 175 citations

Cytokines in T-cell development

1991 • 164 citations

The majority of CD4+8- thymocytes are functionally immature.

1991 • 137 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells.

1985 • 126 citations

Two subsets of epithelial cells in the thymic medulla.

1992 • 116 citations

Differentiation of epithelial cells in the mouse thymus

1970 • 70 citations

Immunosuppression with cyclosporin A alters the thymic microenvironment.

1989 • 56 citations

Ontogeny of a novel CD4⁺CD8⁻CD3⁻thymocyte subpopulation: a comparison with CD4⁻ CD8⁺ CD3⁻thymocytes

1990 • 54 citations

Thymic Dendritic Cells: Phenotype and Function

1990 • 52 citations

I-A-positive nonlymphoid cells and T cell development in murine fetal thymus organ cultures: interleukin 1 circumvents the block in T cell differentiation induced by monoclonal anti-I-A antibodies.

1986 • 51 citations

Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.

1992 • 50 citations

The development of helper T cell precursors in mouse thymus.

1988 • 50 citations

T cell specificity in twice-irradiated F1----parent bone marrow chimeras: failure to detect a role for immigrant marrow-derived cells in imprinting intrathymic H-2 restriction.

1986 • 48 citations

A rapid and simple immunoperoxidase staining procedure for blood and bone marrow samples

1986 • 38 citations

The ontogeny of antigen-presenting cells in fetal thymus evaluated by MLR stimulation.

1983 • 30 citations

The Identity of the Cells that Positively Select Thymocytes

1993 • 10 citations