Nitroglycerin Tolerance in Vitro: Effect on cGMP Turnover in Vascular Smooth Muscle

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Multiple cyclic nucleotide phosphodiesterase activities from rat brain

1971 • 1,054 citations

Cyclic GMP Metabolism and Involvement in Biological Regulation

1977 • 629 citations

Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.

1981 • 527 citations

Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.

1979 • 444 citations

Pharmacological estimation of drug-receptor dissociation constants. Statistical evaluation. I. Agonists.

1971 • 435 citations

DISTRIBUTION OF METALS IN SUBCELLULAR FRACTIONS OF RAT LIVER

1957 • 321 citations

Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols

1980 • 313 citations

Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle

1979 • 301 citations

Vascular neuroeffector Mechanisms

1980 • 279 citations

Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.

1977 • 209 citations

Possible involvement of S‐nitrosothiols in the activation of guanylate cyclase by nitroso compounds

1980 • 173 citations

Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets.

1978 • 156 citations

Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover

1983 • 140 citations

Reversible inactivation of guanylate cyclase by mixed disulfide formation.

1981 • 132 citations

Relationship between nitroglycerin, cyclic GMP and relaxation of vascular smooth muscle

1979 • 123 citations

Vascular tolerance to nitroglycerin and cyclic GMP generation in rat aortic smooth muscle.

1982 • 114 citations

Guanylate cyclase activation by nitroprusside and nitrosoguanidine is related to formation of S-nitrosothiol intermediates

1980 • 96 citations

METABOLISM OF INORGANIC NITRITE AND NITRATE ESTERS

1950 • 90 citations

Soluble guanylate cyclase activation by nitric oxide and its reversal

1983 • 65 citations

Vascular Smooth Muscle Relaxation by Nitro Compounds: Reduced Relaxation and cGMP Elevation in Tolerant Vessels and Reversal of Tolerance by Dithiothreitol

1982 • 63 citations

Determination of the Oil/ Water Distribution Coefficients of Glyceryl Trinitrate and Two Similar Nitrate Esters

1963 • 54 citations

Correlation between Vascular Smooth Muscle Relaxation and Increase in Cyclic GMP Induced by some Organic Nitro Esters

1981 • 29 citations

Effects of cysteine and nitroglycerin on bovine heart guanylate cyclase and on tissue cyclic GMP and lactate of rat atria

1983 • 22 citations

Involvement of sulfhydryl groups in the oxidative modulation of particulate lung guanylate cyclase by nitric oxide and N-methyl-N′-nitro-N-nitrosoguanidine

1982 • 18 citations

Dissociation of increases in cyclic GMP from relaxation of arterial smooth muscle

1981 • 11 citations

Inhibitory Effects of Different Retinoids (Vitamin A Analogues) on the Stimulated Rat Liver Guanylate Cyclase Activity

1982 • 5 citations

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