A Novel Cellular Signaling System Based on the Integration of Phospholipid and Calcium Metabolism

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

Intracellular phospholipases A

1980 • 989 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

Diglyceride lipase: a pathway for arachidonate release from human platelets.

1979 • 696 citations

Prostaglandins released by the Spleen

1968 • 542 citations

Metabolism of [14C]arachidonic acid by human platelets

1976 • 453 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Phospholipid Metabolism in Stimulated Human Platelets

1980 • 367 citations

Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

Phospholipid precursors of prostaglandins

1968 • 333 citations

Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.

1981 • 332 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Role of phosphatidylinositol turnover in alpha1 and of adenylate cyclase inhibition in alpha2 effects of catecholamines

1980 • 298 citations

Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes.

1981 • 293 citations

Corticotropin-(1–24)-tetracosapeptide affects protein phosphorylation and polyphosphoinositide metabolism in rat brain

1981 • 287 citations

Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.

1980 • 287 citations

Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin

1979 • 285 citations

Release and metabolism of arachidonic acid in human neutrophils.

1981 • 281 citations

The Importance of Calcium Ions for the Regulation of Guanosine 3′:5′-Cyclic Monophosphate Levels

1973 • 276 citations

Phospholipids as ionophores.

1976 • 275 citations

Inositol phospholipids in membrane function

1979 • 272 citations

THE DISTRIBUTION AND METABOLISM OF ARACHIDONIC ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS

1977 • 264 citations

Proposed mechanism of cholinergic action in smooth muscle

1980 • 256 citations

Stimulation of phospholipid methylation, Ca2+ influx, and histamine release by bridging of IgE receptors on rat mast cells.

1980 • 256 citations

ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS

1974 • 247 citations

Molecular mechanisms involved in α-adrenergic responses

1981 • 246 citations

PHOSPHOLIPIDS IN SYNAPTIC FUNCTION

1979 • 235 citations

The phosphatidylinositol cycle and the regulation of arachidonic acid production

1981 • 230 citations

Formation of lysophosphatidylcholine by human platelets in response to thrombin. Support for the phospholipase A2 pathway for the liberation of arachidonic acid.

1981 • 217 citations

Mechanism of action of gonadotropin-releasing hormone. Involvement of phospholipid turnover in luteinizing hormone release.

1981 • 208 citations

Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function

1981 • 205 citations

Studies on alpha-adrenergic activation of hepatic glucose output. The role of mitochondrial calcium release in alpha-adrenergic activation of phosphorylase in perfused rat liver.

1979 • 201 citations

Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland

1979 • 193 citations

Muscarinic Receptors in Chromaffin Cell Cultures Mediate Enhanced Phospholipid Labeling but Not Catecholamine Secretion

1981 • 193 citations

Erythrocyte Membrane Polyphosphoinositide Metabolism and the Regulation of Calcium Binding

1972 • 193 citations

Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.

1980 • 188 citations

Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine

1979 • 181 citations

Purification of phosphatidylinositol-specific phospholipase C from rat liver.

1981 • 180 citations

Biosynthesis of lipids in golgi complex and other subcellular fractions from rat liver

1974 • 179 citations

Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A23187

1977 • 178 citations

Modulation of brain polyphosphoinositide metabolism by ACTH-sensitive protein phosphorylation

1980 • 178 citations

Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands.

1980 • 168 citations

Calcium-activated hydrolysis of phosphatidyl-myo-inositol 4-phosphate and phosphatidyl-myo-inositol 4,5-bisphosphate in guinea-pig synaptosomes

1978 • 167 citations

The action of prostaglandin synthetase on 2-arachidonyl-lecithin

1968 • 160 citations

Recent hypotheses regarding the phosphatidylinositol effect

1981 • 156 citations

Control of arachidonic acid accumulation in bone marrow-derived macrophages by acyltransferases.

1981 • 154 citations

Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin

1981 • 152 citations

Activation and inhibition of calcium‐dependent histamine secretion by ATP ions applied to rat mast cells.

1979 • 151 citations

Modulation of purified phospholipase A2 activity from human platelets by calcium and indomethacin

1979 • 150 citations

Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides

1978 • 150 citations

Differential activation of platelet phospholipases by thrombin and ionophore A23187.

1981 • 145 citations

A membrane-bound activity catalysing phosphatidylinositol breakdown to 1,2-diacylglycerol, <scp>d</scp>-myoinositol 1:2-cyclic phosphate and <scp>d</scp>-myoinositol 1-phosphate. Properties and subcellular distribution in rat cerebral cortex

1973 • 141 citations

Regulation of Pancreatic Exocrine Function In Vitro: Initial Steps in the Actions of Secretagogues

1979 • 141 citations

Phosphoinositides. 3. Enzymic hydrolysis of inositol-containing phospholipids

1961 • 137 citations

Molecular actions of angiotensin

1981 • 137 citations

Relationship between phosphatidylinositol synthesis and recovery of 5-hydroxytryptamine-responsive Ca2+ flux in blowfly salivary glands

1979 • 135 citations

Why is phosphatidylinositol degraded in response to stimulation of certain receptors?

1981 • 135 citations

Phosphatidylinositol metabolism in rat hepatocytes stimulated by glycogenolytic hormones. Effects of angiotensin, vasopressin, adrenaline, ionophore A23187 and calcium-ion deprivation

1979 • 133 citations

Effect of various lipoxygenase metabolites of arachidonic acid on degranulation of polymorphonuclear leukocytes.

1981 • 129 citations

Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol

1979 • 129 citations

The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets.

1981 • 125 citations

Indomethacin-induced accumulation of diglyceride in activated human platelets. The role of diglyceride lipase.

1980 • 122 citations

EFFECTS OF ACETYLCHOLINE ON PHOSPHOLIPIDES IN THE PANCREAS

1954 • 122 citations

Transfer of arachidonic acid between phospholipids in rat liver microsomes

1979 • 121 citations

Mechanisms involved in alpha-adrenergic phenomena: role of calcium ions in actions of catecholamines in liver and other tissues

1980 • 118 citations

SEPARATE 5‐HYDROXYTRYPTAMINE RECEPTORS ON THE SALIVARY GLAND OF THE BLOWFLY ARE LINKED TO THE GENERATION OF EITHER CYCLIC ADENOSINE 3‘,5’‐MONOPHOSPHATE OR CALCIUM SIGNALS

1981 • 111 citations

Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides.

1977 • 110 citations

Diacylglycerol metabolism and arachidonic acid release in human fetal membranes and decidua vera.

1981 • 110 citations

Evidence for a role of phosphatidylinositol turnover in stimulus–secretion coupling. Studies with rat peritoneal mast cells

1979 • 107 citations

Characterization of a calcium-mediated activation of arachidonic acid turnover in adrenal phospholipids by corticotropin.

1979 • 106 citations

Hormonal stimulation of arachidonic release from isolated perfused organs relationship to prostaglandin biosynthesis

1977 • 106 citations

The Possible Involvement of Phosphatidylinositol Breakdown in the Mechanism of Stimulus-Response Coupling at Receptors which Control Cell-Surface Calcium Gates

1977 • 105 citations

The activation of phosphatidylinositol-hydrolyzing phospholipase A2 during prostaglandin synthesis in transformed mouse BALB/3T3 cells.

1981 • 104 citations

The possible functional significance of phosphatidylethanolamine methylation

1980 • 100 citations

Phosphoinositide interconversion: A model for control of Na+ and K+ permeability in the nerve axon membrane

1971 • 100 citations

Stimulus–secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown

1980 • 97 citations

The metabolism of phosphatidylinositol in the thyroid gland of the pig

1971 • 96 citations

Lipoxygenase products modulate histamine release in human basophils

1981 • 95 citations

Phosphatidate as a Molecular Link Between Depolarization and Neurotransmitter Release in the Brain

1981 • 95 citations

Relationship of prostaglandin secretion by rabbit alveolar macrophages to phagocytosis and lysosomal enzyme release

1979 • 90 citations

The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments

1975 • 89 citations

Phospholipids as the molecular instruments of ion and solute transport in biological membranes.

1980 • 88 citations

On the mechanism whereby ACTH and cyclic AMP increase adrenal polyphosphoinositides. Rapid stimulation of the synthesis of phosphatidic acid and derivatives of CDP - diacylglycerol.

1980 • 87 citations

PHYSIOLOGICAL SIGNIFICANCE OF POLYPHOSPHOINOSITIDES IN BRAIN ^*

1970 • 84 citations

Calcium ion-dependent diacylglycerol accumulation in erythrocytes is associated with microvesiculation but not with efflux of potassium ions

1977 • 83 citations

Stimulation of phosphatidylinositol turnover in various tissues by cholinergic and adrenergic agonists, by histamine and by caerulein

1979 • 79 citations

Arachidonate metabolite(s) increase the permeability of the plasma membrane of the neutrophils to calcium

1980 • 78 citations

Calcium ion requirement for acetylcholine-stimulated breakdown of triphosphoinositide in rabbit iris smooth muscle.

1978 • 73 citations

Receptors and calcium signalling

1980 • 73 citations

Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products.

1978 • 72 citations

Histamine-Induced release of arachidonic acid and of prostaglandins in the peripheral vascular bed

1980 • 71 citations

Intestinal mucosal cyclic GMP: regulation and relation to ion transport

1976 • 70 citations

Phosphatidylinositol turnover in mitogen-activated lymphocytes. Suppression by low-density lipoproteins

1980 • 62 citations

Metabolism and Role of Phosphatidylinositol in Acetylcholinestimulated Membrane Function

1977 • 61 citations

Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process.

1980 • 61 citations

Evidence for a role in stimulus--secretion coupling of prostaglandins derived from release of arachidonoyl residues as a result of phosphatidylinositol breakdown.

1980 • 59 citations

The relationship of phosphatidylinositol turnover to receptors and calcium-ion channels in rat parotid acinar cells

1981 • 59 citations

Incorporation of inorganic [32P] phosphate into rat parotid phosphatidylinositol. Induction through activation of alpha adrenergic and cholinergic receptors and relation to K+ release.

1975 • 58 citations

f‐MetLeuPhe‐induced phosphatidylinositol turnover in rabbit neutrophils is dependent on extracellular calcium

1980 • 57 citations

Intracellular messenger role of cyclic GMP in exocrine pancreas

1976 • 56 citations

Studies on the properties of triphosphoinositide phosphomonoesterase and phosphodiesterase of rabbit iris smooth muscle

1978 • 54 citations

Light stimulates the incorporation of inositol into phosphatidylinositol in the retina

1981 • 54 citations

Ca2+-dependent and Ca2+-independent degradation of phosphatidylinositol in rabbit vas deferens

1981 • 52 citations

Evidence that phosphatidic acid stimulates the uptake of calcium by liver cells but not calcium release from mitochondria

1981 • 52 citations

Parathyroid Hormone and Adenosine-3′,5′-Monophosphate Acutely Increase Phospholipids of the Phosphatidate-Polyphosphoinositide Pathway in Rabbit Kidney Cortex Tubulesin Vitroby a Cycloheximide-Sensitive Process*

1981 • 51 citations

Nuclear magnetic resonance studies of drug-receptor interactions. The binding of epinphrine to isolated mouse liver cells.

1969 • 50 citations

Potassium and angiotensin II increase the concentrations of phosphatidic acid, phosphatidylinositol, and polyphosphoinositides in rat adrenal capsules in vitro.

1980 • 47 citations

Cyclitols and Phosphoinositides

1979 • 46 citations

Stimulation of inorganic-phosphate incorporation into phosphatidylinositol in rat thoracic aorta mediated through V1-vasopressin receptors

1981 • 45 citations

Stimulation of phosphatidylinositol turnover by histamine, 5-hydroxytryptamine and adrenaline in the longitudinal smooth muscle of guinea pig ileum

1976 • 45 citations

Effect of phagocytosis and lonophores on release and metabolism of arachidonic acid from human neutrophils

1981 • 45 citations

The involvement of prostaglandin endoperoxide formation in the elevation of cyclic GMP levels during platelet aggregation.

1977 • 44 citations

CALCIUM IONOPHORE A23187 INDUCES RELEASE OF CHEMOKINETIC AND AGGREGATING FACTORS FROM POLYMORPHO‐NUCLEAR LEUCOCYTES

1980 • 42 citations

Studies on the properties of a soluble phosphatidylinositol-phosphodiesterase of rabbit iris smooth muscle

1980 • 42 citations

Phosphatidate releases calcium from cardiac sarcoplasmic reticulum

1980 • 40 citations

Phosphatidylinositol Labelling in Response to Activation of Muscarinic Receptors in Bovine Adrenal Medulla

1981 • 40 citations

Calcium and Phospholipid Turnover as Transmembrane Signaling for Protein Phosphorylation

1982 • 40 citations

Temperature Dependence of Muscarinic Acetylcholine Receptor Activation, Desensitization, and Resensitization

1980 • 39 citations

On the relationship between formylmethionyl-leucyl-phenylalanine stimulation of arachidonyl phosphatidylinositol turnover and lysosomal enzyme secretion by rabbit neutrophils.

1981 • 38 citations

The effect of Ca++ omission on the secretion of catecholamines and the incorporation of orthophosphate-32P into nucleotides and phospholipids of bovine adrenal medulla during acetylcholine stimulation.

1969 • 37 citations

Activation of (arachidonyl) phosphatidylinositol turnover in rabbit neutrophils by the calcium ionophore A23187

1981 • 37 citations

Effects of Neomycin on Calcium and Polyphosphoinositide Metabolism of Guinea Pig Synaptosomes

1980 • 35 citations

Involvement of calcium channels in short-term desensitization of muscarinic receptor-mediated cyclic GMP formation in mouse neuroblastoma cells.

1980 • 35 citations

A Possible Role for Phosphatidylinositol Breakdown in Muscarinic Cholinergic Stimulus-Response Coupling

1977 • 33 citations

Effects of Ca2+ ionophore A23187 and Ca2+ deficiency on pancreatic phospholipids and amylase release in vitro

1980 • 30 citations

Enhanced Phosphatidylinositol Breakdown as a Calcium-Independent Response of Rat Parotid Fragments to Substance P

1978 • 29 citations

Substrate requirements for the phosphoinositide response in rat pancreatic islets

1981 • 29 citations

Effect of arachidonic acid and the chemotactic factor F‐Met‐Leu‐Phe on cation transport in rabbit neutrophils

1981 • 28 citations

Stimulated Phosphatidylinositol Turnover A Brief Appraisal

1982 • 26 citations

A proposal for the mechanism by which α-adrenergic agonists, vasopressin, angiotensin and cyclic AMP induce calcium release from intracellular stores in the liver cell: A possible role for metabolites of arachidonic acid

1981 • 26 citations

Insulin and Its Secretagogues Activate Ca2+-dependent Phosphatidylinositol Breakdown and Amylase Secretion in Rat Pancreas In Vitro

1981 • 25 citations

Leukotriene C stimulates prostaglandin release from rat peritoneal macrophages

1981 • 25 citations

The Influence of Extracellular Calcium Concentration on the Vasopressin-Stimulated Incorporation of Inorganic Phosphate into Phosphatidylinositol in Hepatocyte Suspensions

1978 • 25 citations

Phospholipid methylation and human platelet function

1981 • 25 citations

Lanthanum as a Tool to Study the Role of Phosphatidylinositol in the Calcium Transport in Rat Parotid Glands upon Cholinergic Stimulation

1978 • 23 citations

PHYSIOLOGICAL SIGNIFICANCE OF POLYPHOSPHOINOSITIDES IN BRAIN

1970 • 22 citations

Phosphatidylinositol turnover and calcium movement in the rat pancreas

1980 • 21 citations

Arachidonic acid activation of guinea pig lung guanylate cyclase by two independent mechanisms

1979 • 20 citations

Guanylate cyclase from bovine adrenal medulla: Subcellular distribution and studies on the effect of lysolecithin on enzyme activity

1978 • 19 citations

Involvement of phosphatidylinositol breakdown in elevation of cytosol Ca2+ by hormones and relationship to prostaglandin formation.

1982 • 16 citations

Effects of Changes in Calcium Concentration on Basal and Stimulated ³²P Incorporation into Phospholipids in Rat Pineal Cells

1981 • 15 citations

The importance of Ca2+-mediated phospholipase A2 activation for stimulus-evoked PGE2-release from rabbit splenic capsular strips

1979 • 15 citations

Biosynthesis of phosphatidylinositol in Crithidia fasciculata

1980 • 14 citations

The Influence of Divalent Cations and Substrate Concentration on the Incorporation of Myo‐inositol into Phospholipids of Isolated Bovine Oligodendrocytes

1981 • 14 citations

The possible role of lipids in control of membrane fusion during secretion.

1979 • 14 citations

Calcium and O2-dependent control of inner medullary cGMP: Possible role for Ca2+-dependent arachidonate release and prostaglandin synthesis in expression of the action of osmolality on renal inner medullary guanosine 3′5′ monophosphate

1980 • 13 citations

Thyrotropin‐stimulated phosphatidylinositol‐specific phospholipase A₂ in pig thyroid, a re‐examination

1980 • 13 citations

On the Mechanism whereby ACTH and Cyclic AMP Increase Adrenal Polyphosphoinositides

1980 • 12 citations

Transient increase in prostaglandin production as an acute response of thyroid isolated follicles to thyrotropin

1981 • 11 citations

Membrane protein mediation of thromboxane A2 induced platelet aggregation

1980 • 9 citations

Influence of Potassium and Calcium Ions on the Phosphatidylinositol and Phosphatidylcholine Metabolism in Rat Fibroblasts after Growth Stimulation by Calf Serum

1975 • 8 citations

Calcium dependence of prostaglandin release from the guinea pig Taenia coli

1980 • 7 citations

STUDIES ON THE METABOLIC HETEROGENEITY OF DIFFERENT MOLECULAR SPECIES OF PHOSPHATIDYLINOSITOLS

1978 • 6 citations

Deleted Work

1955 • 0 citations