The Possible Involvement of Phosphatidylinositol Breakdown in the Mechanism of Stimulus-Response Coupling at Receptors which Control Cell-Surface Calcium Gates

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

1968 • 1,393 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Transport and metabolism of calcium ions in nerve

1972 • 754 citations

Membrane Receptors

1974 • 636 citations

Metabolism and Physiological Significance of Lipids

1963 • 482 citations

The Sodium-Potassium Adenosinetriphosphatase

1974 • 476 citations

Metabolism of [14C]arachidonic acid by human platelets

1976 • 453 citations

BIOCHEMICAL STUDIES ON MUSCARINIC ACETYLCHOLINE RECEPTORS

1976 • 314 citations

EFFECT OF MAGNESIUM ION ON THE RESPONSE OF THE RAT UTERUS TO NEUROHYPOPHYSIAL HORMONES AND ANALOGUES¹

1960 • 301 citations

Phospholipids as ionophores.

1976 • 275 citations

Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase.

1975 • 265 citations

Hormone and neurotransmitter receptors in an established vascular endothelial cell line.

1976 • 257 citations

Calcium couples flagellar reversal to photostimulation in Chlamydomonas reinhardtii

1976 • 255 citations

Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro.

1975 • 235 citations

The Role of Cyclic AMP and Calcium in Cell Activatio

1972 • 209 citations

Metabolism and Physiological Significance of Lipids

1965 • 197 citations

Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha.

1975 • 196 citations

An early alteration in the phospholipid metabolism of lymphocytes by phytohemagglutinin.

1968 • 167 citations

Acetylcholine Action: Biochemical Aspects

1969 • 152 citations

A membrane-bound activity catalysing phosphatidylinositol breakdown to 1,2-diacylglycerol, <scp>d</scp>-myoinositol 1:2-cyclic phosphate and <scp>d</scp>-myoinositol 1-phosphate. Properties and subcellular distribution in rat cerebral cortex

1973 • 141 citations

Dynamic Aspects of Phospholipids during Protein Secretion

1968 • 137 citations

Phosphatidylinositol metabolism in cells receiving extracellular stimulation

1973 • 127 citations

Activation of guanyl cyclase and intracellular cyclic GMP by fibroblast growth factor

1974 • 125 citations

Regulation of Adenylate Cyclase Coupled β-Adrenergic Receptors by β-Adrenergic Catecholamines

1976 • 123 citations

Breakdown of phosphatidylinositol provoked by muscarinic cholinergic stimulation of rat parotid-gland fragments

1974 • 110 citations

Stimulus-Secretion Coupling in the Gastrointestinal Tract

1976 • 110 citations

Acetylcholine causes a net decrease in phosphatidylinositol and a net increase in phosphatidic acid in mouse pancreas

1974 • 108 citations

Control by TSH of a phospholipase A₂ activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid

1973 • 108 citations

Production of 1,2-diacylglycerol and phosphatidate in human erythrocytes treated with calcium ions and ionophore A23187

1976 • 105 citations

Oscillation of Cyclic Adenosine Monophosphate Concentration during the Myocardial Contraction Cycle

1973 • 100 citations

Receptor occupancy dose—response curve suggests that phosphatidyl‐inositol breakdown may be intrinsic to the mechanism of the muscarinic cholinergic receptor

1976 • 92 citations

The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments

1975 • 89 citations

Phosphoinositide metabolism and insulin secretion from isolated rat pancreatic islets.

1976 • 84 citations

Inter-Relations between the Phospholipids of Rat Pancreatic Islets during Glucose Stimulation and Their Response to Medium Inositol and Tetracaine

1975 • 83 citations

Cyclic changes in levels of cyclic AMP and cyclic GMP in frog myocardium during the cardiac cycle

1973 • 82 citations

Function of muscarinic and nicotinic acetylcholine receptors

1976 • 75 citations

Changes in lipid metabolism and cell morphology following attack by phospholipase C (Clostridium perfringens) on red cells or lymphocytes

1975 • 74 citations

Stimulation of Hydrolysis of Phosphatidic Acid by Cholinergic Agents in Guinea Pig Synaptosomes

1974 • 73 citations

THE DIFFERENT EFFECTS OF D‐600 (METHOXYVERAPAMIL) ON THE RELEASE OF ADRENAL CATECHOLAMINES INDUCED BY ACETYLCHOLINE, HIGH POTASSIUM OR SODIUM DEPRIVATION

1976 • 68 citations

Production of Cyclic Inositol Phosphate in Stimulated Tissues

1972 • 67 citations

Muscarinic cholinergic stimulation of phosphatidylinositol turnover in the longitudinal smooth muscle of guinea-pig ileum

1976 • 66 citations

Function and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems

1976 • 66 citations

Enkephalin regulates the levels of cyclic nucleotides in neuroblastoma × glioma hybrid cells

1976 • 60 citations

Incorporation of inorganic [32P] phosphate into rat parotid phosphatidylinositol. Induction through activation of alpha adrenergic and cholinergic receptors and relation to K+ release.

1975 • 58 citations

Acetylcholine-stimulated phosphodiesteratic cleavage of phosphoinositides: hypothetical role in membrane depolarization.

1969 • 58 citations

Effects of calcium-antagonistic drugs on the stimulation by carbamoylcholine and histamine of phosphatidylinositol turnover in longitudinal smooth muscle of guinea-pig ileum

1976 • 54 citations

Inositol is the water-soluble product of acetylcholine-stimulated breakdown of phosphatidylinositol in mouse pancreas

1975 • 53 citations

Glyceride lipases in nerve endings of guinea-pig brain and their stimulation by noradrenaline, 5-hydroxytryptamine and adrenaline

1973 • 51 citations

Evidence of a Dualism between Cyclic GMP and Cyclic AMP in the Regulation of Cell Proliferation and Other Cellular Processes

1974 • 49 citations

Morphine elevates levels of cyclic GMP in a neuroblastoma X glioma hybrid cell line

1975 • 45 citations

Stimulation of phosphatidylinositol turnover by histamine, 5-hydroxytryptamine and adrenaline in the longitudinal smooth muscle of guinea pig ileum

1976 • 45 citations

Acetylcholine stimulation of selective increases in stearic and arachidonic acids in phosphatidic acid in mouse pancreas

1976 • 45 citations

Existence of two pools of prostaglandins during stimulation of the thyroid by TSH

1974 • 42 citations

Acetylcholine stimulates hydrolysis of 32P-labeled phosphatidic acid in guinea pig synaptosomes

1973 • 42 citations

Investigation of the relationship between cell-surface calcium-ion gating and phosphatidylinositol turnover by comparison of the effects of elevated extracellular potassium ion concentration on ileium smooth muscle and pancreas

1976 • 40 citations

Muscarinic cholinergic stimulation of phosphatidylinositol turnover in isolated rat superior cervical sympathetic ganglia

1976 • 38 citations

The effect of Ca++ omission on the secretion of catecholamines and the incorporation of orthophosphate-32P into nucleotides and phospholipids of bovine adrenal medulla during acetylcholine stimulation.

1969 • 37 citations

THE SUBCELLULAR LOCALIZATION OF CARBAMYLCHOLINE‐STIMULATED PHOSPHATIDYL INOSITOL TURNOVER IN RAT CEREBRAL CORTEX IN VIVO

1975 • 35 citations

Stereoselective and calcium-dependent contractile effects of narcotic antagonist analgesics in the vascular smooth muscle of the rat.

1976 • 34 citations

Cholinergically stimulated phosphatidylinositol breakdown in parotid-gland fragments is independent of the ionic environment

1976 • 33 citations

Adrenergic and cholinergic stimulation of 32P-labeling of phospholipids in rabbit iris muscle

1976 • 32 citations

Differences in the metabolism of phospholipids depending on cell population density

1973 • 32 citations

Ca2+ influx across the excitable membrane of behavioural mutants of Paramecium

1976 • 32 citations

A difference in the breakdown of phosphatidylinositol in normal and SV40 transformed mouse fibroblasts

1973 • 31 citations

Hydrolysis of 1,2-diglyceride by membrane-associated lipase activity during phospholipase C treatment of membranes

1973 • 31 citations

Acetylcholine stimulation on phosphatidylinositol-inositol phosphohydrolase of rat brain cortex

1972 • 30 citations

Role of Inositol Cyclic Phosphate in Stimulated Tissues

1973 • 28 citations

Cholinergic control by endogenous prostaglandins of cAMP accumulation under TSH stimulation in the thyroid

1974 • 27 citations

Effect of ionophore A23187 on thyroid secretion

1974 • 21 citations

Stimulierung von Kulturen embryonaler Rattenzellen durch Kälberserum. V. Verhalten der Inosit- und Cholinphospholipide / Stimulation of Embryonic Rat Cells by Calf Serum. V. Metabolism of Inositol- and Choline Phospholipids

1973 • 20 citations

Quantitative aspects of drug-receptor interactions

1973 • 18 citations

Effects of acetylcholine on incorporation of [¹⁴C]glucose into phosphatidylinositol and on phosphatidylinositol breakdown in subcellular fractions from cerebral cortex

1974 • 13 citations

The Effect of Bradykinin and Kallidin on Smooth Muscle

1970 • 8 citations

Phospholipid Metabolism in Electrically Stimulated Synaptosomes

1976 • 5 citations

Phosphatidylinositol Metabolism and Myoinositol 1,2-Cyclic Phosphate Action in Smooth Muscle

1976 • 4 citations