Coupling of Bone Resorption and Formation during Bone Remodeling

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

1997 • 4,191 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

1998 • 2,473 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

1999 • 2,238 citations

Leptin Inhibits Bone Formation through a Hypothalamic Relay

2000 • 2,045 citations

Prediction of bone density from vitamin D receptor alleles

1994 • 1,931 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 • 1,836 citations

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

1999 • 1,832 citations

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

1999 • 1,660 citations

RANK is essential for osteoclast and lymph node development

1999 • 1,417 citations

Regulation of bone mass by mechanical strain magnitude

1985 • 1,285 citations

Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction

2000 • 1,268 citations

Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro¹

1998 • 1,211 citations

Osteopontin: a protein with diverse functions

1993 • 1,082 citations

Bone and Mineral Research

1990 • 1,070 citations

Modulation of Osteoclast Differentiation

1992 • 1,014 citations

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

1986 • 870 citations

Estrogen Binding, Receptor mRNA, and Biologic Response in Osteoblast-Like Osteosarcoma Cells

1988 • 836 citations

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

1999 • 777 citations

Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur.

1990 • 734 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts

1999 • 697 citations

Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.

1993 • 642 citations

The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents.

1987 • 608 citations

Normal and Pathological Remodeling of Human Trabecular Bone: Three Dimensional Reconstruction of the Remodeling Sequence in Normals and in Metabolic Bone Disease*

1986 • 596 citations

In VivoStimulation of Bone Formation by Transforming Growth Factor-β

1989 • 592 citations

Insights from the study of animals lacking functional estrogen receptor

1994 • 587 citations

Bone and Mineral Research/4

1986 • 581 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

Increased intracortical remodeling following fatigue damage

1993 • 555 citations

Transforming Growth Factor-β Gene Family Members and Bone*

1994 • 493 citations

Osteotropic Agents Regulate the Expression of Osteoclast Differentiation Factor and Osteoprotegerin in Osteoblastic Stromal Cells

1998 • 444 citations

Vascular Endothelial Growth Factor Can Substitute for Macrophage Colony-Stimulating Factor in the Support of Osteoclastic Bone Resorption

1999 • 438 citations

Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

1987 • 434 citations

Osteoblastic Cells Mediate Osteoclastic Responsiveness to Parathyroid Hormone*

1986 • 411 citations

Activated T Lymphocytes Support Osteoclast Formation in Vitro

1999 • 408 citations

Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts.

1994 • 393 citations

Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts.

1986 • 392 citations

Effects of Interleukin-1 on Bone Turnover in Normal Mice*

1989 • 366 citations

Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption

1999 • 364 citations

Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo

1989 • 357 citations

Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1989 • 337 citations

Bone remodelling induced by physical stress is prostaglandin E2 mediated

1980 • 335 citations

Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats.

1994 • 331 citations

Osteopontin is synthesized by macrophage, smooth muscle, and endothelial cells in primary and restenotic human coronary atherosclerotic plaques.

1994 • 314 citations

Bone Mass in Lifetime Tennis Athletes

1980 • 298 citations

Cultured Bovine Bone Cells Synthesize Basic Fibroblast Growth Factor and Store It in Their Extracellular Matrix

1989 • 297 citations

Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation

1989 • 286 citations

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

1989 • 281 citations

Skeletal Renewal and Metabolic Bone Disease

1969 • 280 citations

Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta.

1993 • 267 citations

Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclasts.

1986 • 265 citations

Prostaglandin E2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovariectomized female rats

1990 • 256 citations

Regulatory Role of Transforming Growth Factor-β, Bone Morphogenetic Protein-2, and Protein-4 on Gene Expression of Extracellular Matrix Proteins and Differentiation of Dental Pulp Cells

1994 • 254 citations

Heritability of bone mass: a longitudinal study in aging male twins.

1989 • 252 citations

Consequences of the remodelling process for vertebral trabecular bone structure: a scanning electron microscopy study (uncoupling of unloaded structures)

1990 • 237 citations

Bone cells predispose bone surfaces to resorption by exposure of mineral to osteoclastic contact

1985 • 229 citations

Hormonal and Nutritional Regulation of IGF-I and Its Binding Proteins

1994 • 227 citations

Stimulation of endosteal bone formation by systemic injections of recombinant basic fibroblast growth factor in rats

1995 • 227 citations

Dynamics of bone remodeling

1964 • 222 citations

In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats

1991 • 220 citations

1,25-Dihydroxyvitamin D3 stimulates rat osteoblastic cells to release a soluble factor that increases osteoclastic bone resorption.

1987 • 218 citations

Transforming growth factor-beta and remodeling of bone.

1991 • 216 citations

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice

1999 • 213 citations

Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells.

1994 • 206 citations

Primary structure of human skeletal growth factor: homology with human insulin-like growth factor-II

1988 • 204 citations

Mammalian collagenase predisposes bone surfaces to osteoclastic resorption

1985 • 203 citations

Localization of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) during Human Embryonic Development: High Affinity Binding to Basement Membranes

1994 • 202 citations

The Cellular Basis of Bone Resorption

1980 • 201 citations

Prostaglandin E₂Stimulates Insulin-Like Growth Factor I Synthesis in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1991 • 197 citations

The short-term effects of conjugated estrogen on bone turnover in older women.

1994 • 191 citations

Secreted phosphoproteins associated with neoplastic transformation: close homology with plasma proteins cleaved during blood coagulation.

1988 • 187 citations

Hormonal Regulation of the Production of Collagenase and a Collagenase Inhibitor Activity by Rat Osteogenic Sarcoma Cells*

1987 • 186 citations

TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption

1998 • 179 citations

Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein.

1994 • 173 citations

Fibroblast Growth Factor

1990 • 173 citations

In VivoDistribution of Parathyroid Hormone Receptors in Bone: Evidence that a Predominant Osseous Target Cell Is Not the Mature Osteoblast*

1988 • 156 citations

Pattern of gene expression following rat tibial marrow ablation

1993 • 155 citations

Indomethacin inhibition of tenotomy-induced bone resorption in rats

1988 • 152 citations

Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta.

1991 • 147 citations

Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex.

1992 • 141 citations

Transforming growth factor-beta gene family members and bone

1994 • 138 citations

Expression of bone morphogenetic protein messenger RNA in prolonged cultures of fetal rat calvarial cells

1994 • 133 citations

Perspectives: Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption

1991 • 133 citations

Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat bone.

1993 • 130 citations

Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells.

1989 • 125 citations

Insulin‐like growth factors.

1995 • 121 citations

Latent Forms of Transforming Growth Factor-β (TGFβ) Derived from Bone Cultures: Identification of a Naturally Occurring 100-kDa Complex with Similarity to Recombinant Latent TGFβ

1991 • 119 citations

Benefit of systemically administered rhIGF-I and rhIGF-I/IGFBP-3 on cancellous bone in ovariectomized rats

1994 • 115 citations

Interleukins in the Control of Osteoclast Differentiation

1998 • 113 citations

Characterization of the major parathyroid hormone target cell in the endosteal metaphysis of rat long bones

1990 • 112 citations

Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.

1995 • 106 citations

Bone sialoprotein mRNA expression and ultrastructural localization in fetal porcine calvarial bone: comparisons with osteopontin

1994 • 102 citations

A murine skeletal adaptation that significantly increases cortical bone mechanical properties. Implications for human skeletal fragility.

1993 • 102 citations

Bone sialoprotein mRNA expression and ultrastructural localization in fetal porcine calvarial bone: comparisons with osteopontin

1994 • 96 citations

Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation and activity.

1992 • 90 citations

Long-term anabolic effects of prostaglandin-E2 on tibial diaphyseal bone in male rats

1991 • 90 citations

Opposite effects of insulin-like growth factor-I on the formation of trabecular and cortical bone in adult female rats.

1992 • 85 citations

Stage-specific Expression of Decapentaplegic-Vg-related Genes 2, 4, and 6 (Bone Morphogenetic Proteins 2, 4, and 6) During Human Tooth Morphogenesis

1994 • 84 citations

Purification and characterization of transforming growth factor-beta 2.3 and -beta 1.2 heterodimers from bovine bone.

1992 • 77 citations

Developing human lung and kidney are major sites for synthesis of bone morphogenetic protein-3 (osteogenin).

1994 • 71 citations

Local infusion of prostaglandin E₁ stimulates mandibular bone formation in vivo

1988 • 66 citations

Spaceflight results in reduced mRNA levels for tissue-specific proteins in the musculoskeletal system

1994 • 66 citations

A computerised technique for the quantitative assessment of resorption cavities in trabecular bone

1990 • 54 citations

The effects of age on the response of rabbit periosteal osteoprogenitor cells to exogenous transforming growth factor-β2

1994 • 53 citations

Autoradiographic localization of osteogenin binding sites in cartilage and bone during rat embryonic development

1990 • 48 citations

The plasminogen activator and inhibitor system in bone remodelling.

1993 • 47 citations

Determination and expression of platelet-derived growth factor-AA in bone cell cultures.

1992 • 46 citations

Partial Characterization of a Parathyroid Hormone-Stimulated Resorption Factor(s) from Osteoblast-Like Cells*

1989 • 45 citations

A New Method for Identification of Cement Lines in Undecalcified, Plastic Embedded Sections of Bone

1986 • 33 citations

The Short-Term Effects of Conjugated Estrogen on Bone Turnover in Older Women

1995 • 26 citations

Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system.

1991 • 24 citations

The hematopoietic microenvironment : the functional and structural basis of blood cell development

1993 • 15 citations