Drugs Affecting the Renal Handling of Uric Acid

DIFFERENTIAL SPECTROPHOTOMETRY OF PURINE COMPOUNDS BY MEANS OF SPECIFIC ENZYMES

1947 • 1,102 citations

Renal tubular mechanisms for excretion of organic acids and bases

1964 • 241 citations

STUDY OF THE PARADOXICAL EFFECTS OF SALICYLATE IN LOW, INTERMEDIATE AND HIGH DOSAGE ON THE RENAL MECHANISMS FOR EXCRETION OF URATE IN MAN *

1959 • 205 citations

Factors affecting urate excretion following diuretic administration in man

1969 • 183 citations

The renal mechanism for urate homeostasis in normal man

1967 • 173 citations

Physiology of the Human Kidney.

1969 • 167 citations

‘Benemid,’ p-(di-n-Propylsulfamyl)-Benzoic Acid: Its Renal Affinity and Its Elimination

1951 • 161 citations

TUBULAR SECRETION OF URATE IN MAN*

1959 • 159 citations

EFFECT OF CHLOROTHIAZIDE ON ELECTROLYTE TRANSPORT IN MAN

1958 • 153 citations

THE RENAL MECHANISM FOR URATE EXCRETION IN MAN 1

1950 • 137 citations

THE COMPARATIVE PHYSIOLOGY OF THE KIDNEY IN RELATION TO THEORIES OF RENAL SECRETION

1934 • 136 citations

Pharmacology of pyrazinamide: metabolic and renal function studies related to the mechanism of drug-induced urate retention.

1972 • 131 citations

The influence of the extracellular fluid volume on the tubular reabsorption of uric acid.

1975 • 127 citations

THE URIC ACID PROBLEM

1924 • 118 citations

Recent Advances in Renal Physiology and Pharmacology

1975 • 109 citations

A three-component system for regulation of renal excretion of uric acid in man.

1961 • 108 citations

Uricosuric Action of Cholecystographic Agents

1971 • 103 citations

Influence of the kidney upon urate homeostasis in health and disease

1974 • 97 citations

EFFECT OF BENEMID (p-[di-n-PROPYLSULFAMYL]-BENZOIC ACID) ON URATE CLEARANCE AND OTHER DISCRETE RENAL FUNCTIONS IN GOUTY SUBJECTS 1

1952 • 90 citations

Effect of chlorothiazide on the renal excretion of uric acid

1962 • 86 citations

Uricosuric Drugs, with Special Reference to Probenecid and Sulfinpyrazone

1966 • 84 citations

OBSERVATIONS CONCERNING THE CAUSES OF THE EXCESS EXCRETION OF URIC ACID IN THE DALMATIAN DOG

1948 • 80 citations

Effect of Pyrazinamide and Pyrazinoic Acid on Urate Clearance and Other Discrete Renal Functions.

1957 • 80 citations

Tubular secretion of urate in the dog

1960 • 75 citations

Biochemistry of the Alligator

1965 • 75 citations

RENAL FUNCTION IN PATIENTS WITH GOUT 1

1940 • 75 citations

The kidney and uric acid excretion in man

1972 • 67 citations

Origins of the Uricosuric Response

1973 • 66 citations

Handling of uric acid by the rat kidney

1971 • 65 citations

Bidirectional urate transport limited to the proximal tubule in dogs

1968 • 63 citations

The binding of urate to plasma proteins determined by means of equilibrium dialysis.

1970 • 62 citations

Urate-2-14C transport in the rat nephron

1971 • 61 citations

Ultrafiltrability of Plasma Urate in Man.

1953 • 60 citations

Localization of urate transport in the nephron of mongrel and Dalmatian dog kidney

1959 • 58 citations

Pyrazinoate Excretion in the Chimpanzee. RELATION TO URATE DISPOSITION AND THE ACTIONS OF URICOSURIC DRUGS

1973 • 56 citations

Control of Uric Acid Excretion

1971 • 55 citations

Hyperuricemia induced by the administration of chlorthalidone and other sulfonamide diuretics

1962 • 51 citations

Binding of urate to proteins of human and rabbit plasma

1968 • 49 citations

Functional characteristics of renal urate transport in the Cebus monkey

1970 • 49 citations

Effect of drugs that alter uric acid excretion in man on uric acid clearance in the chicken

1960 • 48 citations

Potassium-Depletion Syndrome Secondary to Nephropathy Apparently Caused by Outdated Tetracycline

1965 • 47 citations

Tubular Excretion of Uric Acid in Rabbits.

1954 • 47 citations

Renal excretion of uric acid in the dog

1968 • 45 citations

Influence of inorganic electrolytes and ouabain on uric acid transport

1965 • 41 citations

Urate Secretion in Man: The Pyrazinamide Suppression Test

1973 • 41 citations

Proximal tubular reabsorption of some organic acids in the rat kidney in vivo

1965 • 41 citations

Uric Acid in Human Plasma III. Investigations on the Interaction Between the Urate Ion and Human Albumin

1965 • 41 citations

Low uricase activity in the Dalmatian dog simulated in mongrels given oxonic acid

1971 • 41 citations

Accumulation of uric acid by slices of kidney cortex

1961 • 41 citations

Effect of single oral doses of benzbromarone on serum and urinary uric acid

1974 • 39 citations

SALYRGAN AND RENAL TUBULAR SECRETION OF PARAAMINOHIPPURATE IN THE DOG AND MAN

1948 • 39 citations

Handling of uric acid by the rat kidney

1972 • 39 citations

Renal tubular secretion of uric acid in the mongrel dog

1960 • 37 citations

Stop-flow analysis of tubular transport of uric acid in rabbits

1964 • 37 citations

Effect of metabolic alkalosis and acidosis on tubular urate secretion in water snakes

1968 • 37 citations

Localization and Pyrazinamide Inhibition of Distal Transtubular Movement of Uric Acid-2-C14 with a Modified Stop-Flow Technique*

1965 • 36 citations

Renal urate transport in the chimpanzee

1971 • 36 citations

Binding levels of urate ions in human serum albumin and plasma

1971 • 35 citations

Uric Acid in Human Plasma III. Investigations on the Interaction Between the Urate Ion and Human Albumin

1965 • 32 citations

Effects of mercurial diuretics on renal transport of urate in the chimpanzee

1973 • 31 citations

Renal transport of uric acid in the guinea pig

1968 • 30 citations

Urate handling by the rat kidney

1974 • 30 citations

Renal mechanisms for regulation of uric acid excretion, with special reference to normal and gouty man

1972 • 29 citations

Excretion of urate by the kidneys of Cebus monkeys: a micropuncture study

1973 • 29 citations

Effects of probenecid, sodium salicylate, 2,4-dinitrophenol and pyrazinamide on renal secretion of uric acid in chickens.

1959 • 29 citations

Nature of the uricosuric action of benziodarone

1973 • 28 citations

Hypoglycemic and uricosuric properties of acetohexamide and hydroxyhexamide

1968 • 25 citations

THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND

1950 • 25 citations

The Tubular Site of Urate Transport in the Rabbit Kidney, and the Effect of Probenecid on Urate Secretion

1965 • 25 citations

Quantitative analysis of uric acid in blood and urine; methods and interpretation.

1957 • 24 citations

Uric acid metabolism in Cebus monkeys

1971 • 24 citations

Uric Acid in Nonhuman Primates with Special Reference to Its Renal Transport

1974 • 24 citations

Urate clearance in Cebus monkeys

1968 • 23 citations

Hypolipidemic, uricosuric, and thyroxine‐displacing effects of MK‐185 (halofenate)

1971 • 22 citations

Kidney Secretion in Reptiles

1932 • 21 citations

Uric Acid Elimination in Man¹

1935 • 21 citations

Renal effects of uricosuric agents in the chimpanzee.

1971 • 21 citations

Comparison of renal tubular transport of urate and PAH in water snakes: Evidence for differences in mechanisms and sites of transport

1970 • 21 citations

Inhibition of Uric Acid Exeretion in Rabbits given Probenecid or Salicylic Acid.

1955 • 21 citations

Urate interaction with plasma proteins and erythrocytes

1974 • 20 citations

Uricosuric potency of 2-substituted analogs of probenecid.

1972 • 20 citations

Studies on renal urate secretion in the dog.

1971 • 19 citations

Pharmacologic Approach to the Maintenance of Urate Homeostasis

1975 • 19 citations

(1-Oxo-2-substituted-5-indanyloxy)acetic acids, a new class of potent renal agents possessing both uricosuric and saluretic activity. Reexamination of the role of sulfhydryl binding in the mode of action of acylphenoxyacetic acid saluretics

1975 • 18 citations

Renal clearance of uric acid in nonhuman primates

1970 • 17 citations

Renal Urate Excretion in Normal Man

1975 • 17 citations

Uricosuric Effect of Chlorprothixene

1965 • 16 citations

Renal effects of uricosuric agents in the Cebus monkey.

1970 • 16 citations

Renal excretion and uricosuric properties of halofenate, a hypolipidemic-uricosuric agent, in the chimpanzee.

1972 • 16 citations

Handling of uric acid by the rat kidney

1973 • 16 citations

Clearance Experiments on the Effect of Probenecid on Urate Excretion in the Rabbit

1965 • 16 citations

Renal Urate Excretion in Animal Models

1975 • 16 citations

The relation between secretion of urate and p‐aminohippurate in the rabbit kidney

1967 • 15 citations

Urinary Excretion of Uric Acid in the Dalmatian and Non-Dalmatian Dog Following Administration of Diodrast, Sodium Salicylate and a Mercurial Diuretic

1950 • 15 citations

Species variations among primates in responses to drugs which alter the renal excretion of uric acid.

1975 • 15 citations

M�canismes de l'excr�tion d'acide urique chez le rat

1971 • 13 citations

Choice of experimental animals for research.

1961 • 13 citations

Uricosuric effect of glyceryl guaiacolate.

1974 • 13 citations

Two lectures on renal physiology.

1966 • 13 citations

Uricosuric Effect of an Anticholinergic Agent in Hyperuricemic Subjects

1974 • 12 citations

Renal synthesis of uric acid

1973 • 11 citations

The renal tubular transport of urate

1965 • 11 citations

Hyperuricemia Induced by Ethambutol

1974 • 10 citations

Uricosuric effect of benziodarone in man and laboratory animals: a comparative study

1973 • 10 citations

In vivo studies on uricase activity in the rat

1974 • 10 citations

Studies of the uricosuric action of the hypolipidemic drug halofenate

1973 • 9 citations

Effects of mercurial diuretics on the renal tubular transport of p-aminohippurate and diodrast in the chimpanzee.

1972 • 9 citations

Effet d'inhibiteurs des transports transtubulaires sur l'excr�tion r�nale d'acide urique chez le rat

1971 • 9 citations

Uricosuric agents

1975 • 8 citations

Urate excretion and urine flow in a lithium-induced diabetes insipidus rat model

1974 • 8 citations

THE EFFECT OF CHLOROTHIAZIDE ON THE EXCRETION OF URIC ACID AND ELECTROLYTES BY THE CHICKEN.

1963 • 8 citations

The renal accumulation of urate and p‐aminohippurate in the rabbit

1967 • 8 citations

The renal handling of zoxazolamine (flexin).

1968 • 7 citations

Effects of mercurial diuretics on renal transport of urate and p-aminohippurate in the Cebus monkey

1973 • 6 citations

Urate binding: a clue to the pathogenesis of gout.

1974 • 5 citations

IUD and Endocarditis

1973 • 4 citations

Tubular Site of Urate Secretion in the Rabbit

1965 • 2 citations

Some Contributions of Exotic Animals to Biomedical Research

1964 • 2 citations

Potential species new to laboratory investigation.

1967 • 1 citations

Mechanisms of Renal Excretion of Urate in the Rat

1974 • 1 citations