Renal mechanisms for regulation of uric acid excretion, with special reference to normal and gouty man

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Thomas, Springfield, Illinois

1965 • 2,935 citations

The Metabolic Basis of Inherited Disease.

1972 • 1,407 citations

The Kidney: Structure and Function in Health and Disease

1952 • 1,326 citations

Diseases of the kidney

1963 • 829 citations

Physiology of the Kidney and Body Fluids

1963 • 633 citations

The Kidney: Structure and Function in Health and Disease.

1951 • 463 citations

Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency in Gout

1969 • 452 citations

Non-ionic diffusion and the excretion of weak acids and bases

1958 • 377 citations

Uric acid nephrolithiasis

1968 • 324 citations

Studies on Kidney Function

1926 • 290 citations

Physiology of the Human Kidney

1970 • 289 citations

Diseases of metabolism

1947 • 278 citations

Renal function in gout

1957 • 266 citations

Secretion of organic anions in the formation of urine and bile.

1959 • 262 citations

Physiology of the Kidney and Body Fluids.

1969 • 257 citations

The Kidney in Gout

1960 • 249 citations

Renal tubular mechanisms for excretion of organic acids and bases

1964 • 241 citations

URIC ACID PRODUCTION IN GOUT

1961 • 230 citations

OBSERVATIONS ON THE COMPOSITION OF GLOMERULAR URINE, WITH PARTICULAR REFERENCE TO THE PROBLEM OF REABSORPTION IN THE RENAL TUBULES

1924 • 220 citations

STUDY OF THE PARADOXICAL EFFECTS OF SALICYLATE IN LOW, INTERMEDIATE AND HIGH DOSAGE ON THE RENAL MECHANISMS FOR EXCRETION OF URATE IN MAN *

1959 • 205 citations

Renal clearance of oxipurinol, the chief metabolite of allopurinol

1968 • 201 citations

Role of the intestinal tract in the elimination of uric acid

1965 • 197 citations

QUANTITATIVE CLINICAL CHEMISTRY. INTERPRETATIONS

1947 • 191 citations

Factors affecting urate excretion following diuretic administration in man

1969 • 183 citations

IV. On the structure and use of the Malpighian bodies of the kidney, with observations on the circulation through that gland

1842 • 176 citations

The renal mechanism for urate homeostasis in normal man

1967 • 173 citations

Excretion in fresh-water turtle (Pseudemys scripta) and desert tortoise (Gopherus agassi)

1966 • 168 citations

Physiology of the Human Kidney.

1969 • 167 citations

‘Benemid,’ p-(di-n-Propylsulfamyl)-Benzoic Acid: Its Renal Affinity and Its Elimination

1951 • 161 citations

TUBULAR SECRETION OF URATE IN MAN*

1959 • 159 citations

Effects of food, fast and alcohol on serum uric acid and acute attacks of gout

1967 • 149 citations

Effect of angiotensin and norepinephrine upon urate clearance in man

1968 • 147 citations

THE RENAL EXCRETION OF URIC ACID IN PATIENTS WITH GOUT AND IN NONGOUTY SUBJECTS *†

1959 • 144 citations

THE RENAL MECHANISM FOR URATE EXCRETION IN MAN 1

1950 • 137 citations

THE COMPARATIVE PHYSIOLOGY OF THE KIDNEY IN RELATION TO THEORIES OF RENAL SECRETION

1934 • 136 citations

Evidence for altered renal urate reabsorption during changes in volume of the extracellular fluid.

1969 • 132 citations

Pharmacology of pyrazinamide: metabolic and renal function studies related to the mechanism of drug-induced urate retention.

1972 • 131 citations

Hypouricemia: with evidence for tubular elimination of uric acid.

1950 • 126 citations

Renal Retention of Uric Acid Induced by Infusion of Beta-Hydroxybutyrate and Acetoacetate

1965 • 126 citations

THE URIC ACID PROBLEM

1924 • 118 citations

The Secretion of the Urine

2010 • 110 citations

Uricosuric Effect of Radiocontrast Agents

1971 • 109 citations

A three-component system for regulation of renal excretion of uric acid in man.

1961 • 108 citations

Paradoxical Retention of Uric Acid by Uricosuric Drugs in Low Dosage.

1955 • 106 citations

A definition of substrate specificity in renal transport of organic anions

1965 • 106 citations

Uricosuric Action of Cholecystographic Agents

1971 • 103 citations

THE RENAL EXCRETION OF URIC ACID IN GOUT

1962 • 103 citations

An abnormality of glutamine metabolism in primary gout

1963 • 102 citations

Mikroskopische Beiträge zur Anatomie und Physiologie der Nieren

1874 • 101 citations

RENAL TUBULAR EXCRETION

1939 • 100 citations

Diseases of captive reptiles.

1968 • 99 citations

Diminished Renal Urate Secretion Per Nephron As a Basis for Primary Gout

1970 • 94 citations

The contribution of residual nephrons within the chronically diseased kidney to urate homeostasis in man

1967 • 91 citations

EFFECT OF BENEMID (p-[di-n-PROPYLSULFAMYL]-BENZOIC ACID) ON URATE CLEARANCE AND OTHER DISCRETE RENAL FUNCTIONS IN GOUTY SUBJECTS 1

1952 • 90 citations

Pathogenesis of Hyperuricemia in Saturnine Gout

1969 • 87 citations

Effect of chlorothiazide on the renal excretion of uric acid

1962 • 86 citations

Degradation of uric acid in man.

1959 • 84 citations

A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671.

1957 • 84 citations

Uricosuric Drugs, with Special Reference to Probenecid and Sulfinpyrazone

1966 • 84 citations

THE OCCURRENCE AND STRUCTURE OF MICROBODIES

1965 • 83 citations

The Competitive Inhibition of Uricase by Oxonate and by Related Derivatives of s-Triazines

1965 • 82 citations

Uricase Inhibition in the Rat by s-Triazines: An Animal Model for Hyperuricemia and Hyperuricosuria

1969 • 80 citations

OBSERVATIONS CONCERNING THE CAUSES OF THE EXCESS EXCRETION OF URIC ACID IN THE DALMATIAN DOG

1948 • 80 citations

Effect of Pyrazinamide and Pyrazinoic Acid on Urate Clearance and Other Discrete Renal Functions.

1957 • 80 citations

A COMPARISON OF THE FUNCTION OF THE GLOMERULAR AND AGLOMERULAR KIDNEY

1930 • 77 citations

Renal function in gout

1969 • 76 citations

THE SECRETORY FUNCTION OF THE RENAL TUBULES

1924 • 75 citations

RENAL FUNCTION IN PATIENTS WITH GOUT 1

1940 • 75 citations

Tubular secretion of urate in the dog

1960 • 75 citations

144. Untersuchungen zur Physiologie und Pathologie der Harnsäure bei Säugethieren

1898 • 74 citations

Mechanisms of renal tubular transport

1958 • 73 citations

Zoxazolamine

1958 • 72 citations

Renal function in gout

1962 • 71 citations

RENAL DISEASE IN PRIMARY GOUT

1968 • 70 citations

Quantitative clinical chemistry. Interpretations

1947 • 69 citations

Versuche über den Vorgang der Harnabsonderung, in Verbindung mit Herrn stud. med. A. Neisser

1874 • 67 citations

Handling of uric acid by the rat kidney

1971 • 65 citations

Bidirectional urate transport limited to the proximal tubule in dogs

1968 • 63 citations

Rarity of X-Linked Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency in a Large Gouty Population

1972 • 63 citations

The binding of urate to plasma proteins determined by means of equilibrium dialysis.

1970 • 62 citations

Urate-2-14C transport in the rat nephron

1971 • 61 citations

Ultrafiltrability of Plasma Urate in Man.

1953 • 60 citations

Uric Acid in Human Plasma: V. Isolation and Identification of Plasma Proteins Interacting with Urate

1966 • 59 citations

Localization of urate transport in the nephron of mongrel and Dalmatian dog kidney

1959 • 58 citations

Control of Uric Acid Excretion

1971 • 55 citations

Secretion of purines by the small intestine: general characteristics

1968 • 55 citations

The excretion of uric acid by the chicken

1938 • 54 citations

Secretion as a factor in elimination by the bird's kidney

1924 • 54 citations

QUANTITATIVE STUDIES OF THE COMPOSITION OF GLOMERULAR URINE

1933 • 54 citations

URINE FORMATION IN THE AMPHIBIAN KIDNEY

1935 • 53 citations

Hyperuricemia induced by high fat diets and starvation

1965 • 53 citations

Functional characteristics of renal urate transport in the Cebus monkey

1970 • 49 citations

Binding of urate to proteins of human and rabbit plasma

1968 • 49 citations

Factors influencing renal excretion of foreign organic acids

1964 • 48 citations

Effect of drugs that alter uric acid excretion in man on uric acid clearance in the chicken

1960 • 48 citations

Tubular Excretion of Uric Acid in Rabbits.

1954 • 47 citations

Fortgesetzte Untersuchungen über die Secretion der Niere

1878 • 47 citations

Uric Acid Dihydrate in Bird Urine

1971 • 46 citations

Renal excretion of uric acid in the dog

1968 • 45 citations

Mechanisms of Drug Absorption and Excretion The Renal Excretion of Drugs and Related Compounds

1967 • 45 citations

Uric Acid in Blood and Urine.

1938 • 43 citations

Effect of drugs on urate binding to plasma proteins

1969 • 43 citations

Metabolic Aspects of Renal Function

1961 • 43 citations

Avian nephritis and visceral gout.

1959 • 42 citations

Uric Acid Metabolism in Dalmatians and Other Dogs

1972 • 42 citations

Uric Acid in Human Plasma III. Investigations on the Interaction Between the Urate Ion and Human Albumin

1965 • 41 citations

Low uricase activity in the Dalmatian dog simulated in mongrels given oxonic acid

1971 • 41 citations

Accumulation of uric acid by slices of kidney cortex

1961 • 41 citations

Significance of the renal clearance of uric acid in normal and gouty man

1964 • 40 citations

Ueber die Ausscheidung der Harnsäure durch die Nieren

1896 • 40 citations

Suppression of Tubular Secretion of Urate by Pyrazinamide in the Dog.

1961 • 40 citations

Factors basic to the development of useful inhibitors of renal transport mechanisms.

1954 • 39 citations

Die Natur und Behandlung der Gicht

1882 • 39 citations

THE RENAL EXCRETION OF URATE IN CHRONIC LEAD NEPHROPATHY

1965 • 39 citations

Renal Regulation of Acid-Base Balance in the Chicken

1955 • 38 citations

Views on the Pathogenesis and Management of Primary Gout-1971

1972 • 37 citations

Stop-flow analysis of tubular transport of uric acid in rabbits

1964 • 37 citations

Effect of metabolic alkalosis and acidosis on tubular urate secretion in water snakes

1968 • 37 citations

Renal tubular secretion of uric acid in the mongrel dog

1960 • 37 citations

Evidence for a Three‐Component System of Renal Excretion

1947 • 36 citations

Renal urate transport in the chimpanzee

1971 • 36 citations

Localization and Pyrazinamide Inhibition of Distal Transtubular Movement of Uric Acid-2-C14 with a Modified Stop-Flow Technique*

1965 • 36 citations

Binding levels of urate ions in human serum albumin and plasma

1971 • 35 citations

Renal Excretion of Urate in Patients With Gout

1964 • 34 citations

Increased renal excretion of urate in young patients with gout

1950 • 33 citations

Hyperuricemia induced by drugs

1965 • 33 citations

Experimental Urate Nephropathy: Studies of the Distribution of Urate in Renal Tissue

1964 • 33 citations

Genetic studies in primary gout

1968 • 33 citations

Über die Anomalie der Harnsäurelöslichkeit (kolloide Harnsäure).

1913 • 32 citations

Effect of phloridzin on uric acid excretion in man

1970 • 32 citations

Uric Acid in Human Plasma III. Investigations on the Interaction Between the Urate Ion and Human Albumin

1965 • 32 citations

Physiopathology, Clinical Manifestations, and Treatment of Gout : Part 1. Physiopathology and Pathogenesis

1958 • 31 citations

Renal transport mechanisms.

1967 • 31 citations

Metabolic Aspects of Renal Function

1960 • 31 citations

Spherical Urine in Birds: Petrography

1969 • 31 citations

THE URICASE OF DOGS, INCLUDING THE DALMATIAN

1938 • 30 citations

Renal transport of uric acid in the guinea pig

1968 • 30 citations

THE EFFECT OF DIODRAST ON THE NORMAL URIC ACID CLEARANCE 1

1944 • 29 citations

Effects of probenecid, sodium salicylate, 2,4-dinitrophenol and pyrazinamide on renal secretion of uric acid in chickens.

1959 • 29 citations

THE PURINE METABOLISM OF THE DALMATIAN COACH HOUND

1918 • 27 citations

THE TRANSPORT AND EXCRETION OF URIC ACID IN MAN. I. TRUE URIC ACID IN NORMAL CEREBROSPINAL FLUID, IN PLASMA, AND IN ULTRAFILTRATES OF PLASMA

1947 • 27 citations

Etude chez l’homme de la cinétique d’apparition dans l’urine de l’acide urique 2 <sup>14</sup>C

1968 • 27 citations

Competitive inhibition and specificity of renal tubular transport mechanisms.

1954 • 26 citations

Renal urate excretion in gout studied by feeding ribonucleic acid

1965 • 25 citations

THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND

1950 • 25 citations

Uric Acid Transport System: Apparent Absence in Erythrocytes of the Dalmatian Coach Hound

1964 • 25 citations

The Tubular Site of Urate Transport in the Rabbit Kidney, and the Effect of Probenecid on Urate Secretion

1965 • 25 citations

Renal Excretion of Uric Acid in Leukemia and Gout

1962 • 25 citations

Effect of glycine loading on plasma and urinary uric acid and amino acids in normal and gouty subjects

1970 • 24 citations

Some cases of gout in reptiles

1960 • 24 citations

CONCENTRATION AND TRANSPORT OF TRUE URATE IN THE PLASMA OF THE AZOTEMIC CHICKEN

1947 • 24 citations

Entstehung und Wesen der “Vogelgicht” und ihre Beziehungen zur Arthritis urica des Menschen

1900 • 23 citations

Effect of Reciprocal Allogeneic Renal Transplantation Between Dalmatian and Non-Dalmatian Dogs on Urinary Excretion of Uric Acid.

1966 • 23 citations

CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE: A COMPARATIVE STUDY OF THEIR HYPOTENSIVE, SALURETIC AND HYPERURICEMIC ACTION

1960 • 23 citations

Urate clearance in Cebus monkeys

1968 • 23 citations

Effects of tubular secretion and reabsorption on titration curves of tubular transport

1961 • 22 citations

THE SECRETION OF URIC ACID BY THE FOWL

1929 • 22 citations

URIC ACID PARTITION IN GOUT AND IN HEPATIC DISEASE

1942 • 22 citations

Renal tubular reabsorption of p-aminohippuric acid (PAH)in the dog.

1970 • 22 citations

The Distribution of Urate in Human and Primate Kidney

1968 • 22 citations

Kidney Secretion in Reptiles

1932 • 21 citations

Comparison of renal tubular transport of urate and PAH in water snakes: Evidence for differences in mechanisms and sites of transport

1970 • 21 citations

The excretion of uric acid by the kidney

1926 • 21 citations

Inhibition of Uric Acid Exeretion in Rabbits given Probenecid or Salicylic Acid.

1955 • 21 citations

Renal effects of uricosuric agents in the chimpanzee.

1971 • 21 citations

The Pathogenesis of Gout

1961 • 21 citations

Uric Acid Elimination in Man¹

1935 • 21 citations

Physikalisch-chemisches Verhalten der Harnsäure und ihrer Salze im Blut

1909 • 20 citations

The Cyclopedia of Medicine, Surgery, Specialties.

1952 • 20 citations

Bidirectional active transport of m-hydroxybenzoate in proximal tubule of dogs

1970 • 20 citations

Uricosuric potency of 2-substituted analogs of probenecid.

1972 • 20 citations

Uric Acid in Blood and Urine

1938 • 20 citations

The renal mechanisms for the excretion of m-hydroxybenzoic acid in Cebus monkeys: relationship to urate transport.

1971 • 20 citations

Studies on renal urate secretion in the dog.

1971 • 19 citations

Renal regulation of uric acid excretion in normal and gouty man; modification by uricosuric agents.

1958 • 18 citations

Renal clearance of uric acid in nonhuman primates

1970 • 17 citations

Visceral gout in captive reptiles.

1967 • 16 citations

Clearance Experiments on the Effect of Probenecid on Urate Excretion in the Rabbit

1965 • 16 citations

Renal effects of uricosuric agents in the Cebus monkey.

1970 • 16 citations

The effects of intravenous administration of uric acid on its concentration in plasma and urine of Dalmatian and non-Dalmatian dogs.

1961 • 16 citations

THE TRANSPORT OF URIC ACID IN SERUM

1958 • 16 citations

Renal excretion and uricosuric properties of halofenate, a hypolipidemic-uricosuric agent, in the chimpanzee.

1972 • 16 citations

On variations in the uric acid clearance after administration of purine, with special reference to the threshold problem

1939 • 16 citations

Stop-flow study of renal function in conscious water snakes (natrix sipedon)

1967 • 15 citations

Urinary Excretion of Uric Acid in the Dalmatian and Non-Dalmatian Dog Following Administration of Diodrast, Sodium Salicylate and a Mercurial Diuretic

1950 • 15 citations

The Excretion of Urate at Various Plasma Concentrations and During Osmotic Diuresis in the Rabbit

1966 • 14 citations

ON THE EXCRETION OF URIC ACID AND URATES BY THE BIRD

1933 • 13 citations

Renal Allotransplantation and Allantoin Excretion of Dalmatian

1965 • 13 citations

Diagnosis of Gout.

1939 • 13 citations

Experimentelle Untersuchungen übergeformte Harnsäureausscheidung in den Nieren

1913 • 13 citations

Synovial gout in the parakeet.

1959 • 13 citations

The Urate‐Binding Alpha₁–₂Globulin

1971 • 13 citations

Experimental gout in turkeys

1936 • 13 citations

Electromigration on Filter Paper of Uric Acid from Serum and Synovial Fluid

1958 • 12 citations

The renal tubular transport of urate

1965 • 11 citations

Effect of sodium lactate on urate clearance in the Dalmatian and in the mongrel

1964 • 11 citations

Über die Harnsäureausscheidung durch die Froschniere

1932 • 11 citations

Biochemical and genetic studies of an X-linked neurological disease (The Lesch-Nyhan syndrome).

1971 • 11 citations

Uric acid metabolism in dalmatians and other dogs. Role of the liver

1972 • 10 citations

The Pathogenesis of Gout

2015 • 10 citations

EFFECT OF SODIUM SALICYLATE UPON THE URIC ACID CLEARANCE OF THE DALMATIAN DOG

1948 • 10 citations

The Effects of D‐ and L‐lactate and Osmotic Diuretics on Uric Acid Clearance in the Rabbit

1962 • 10 citations

Excretion of <scp>l</scp>-malic acid in the chicken

1960 • 9 citations

Ultrafiltration of Plasma Uric Acid

1951 • 9 citations

RATE OF ENTRANCE OF URATE AND ALLANTOIN INTO THE CEREBROSPINAL FLUID OF THE DALMATIAN AND NON-DALMATIAN DOG

1949 • 8 citations

THE EFFECT OF CHLOROTHIAZIDE ON THE EXCRETION OF URIC ACID AND ELECTROLYTES BY THE CHICKEN.

1963 • 8 citations

Specific and Non-specific Competition in Tubular Excretion

1948 • 6 citations

Excretion of <scp>d</scp>-malic acid in the chicken

1960 • 5 citations

Bilirubinemia and Fasting

1970 • 5 citations

Urinary excretion of uric acid after instantaneous intra-renal-arterial injection in mongrel and Dalmation dogs.

1970 • 2 citations

[Action of benziodarone in 25 cases of uric gout].

1968 • 1 citations

Monkey Uricase

1970 • 1 citations

Deleted Work

1955 • 0 citations