Renal tubular mechanisms for excretion of organic acids and bases

The Kidney: Structure and Function in Health and Disease

1952 • 1,326 citations

DETOXICATION MECHANISMS

1960 • 760 citations

CALCULATION OF INTRACELLULAR pH FROM THE DISTRIBUTION OF 5,5-DIMETHYL-2,4-OXAZOLIDINEDIONE (DMO). APPLICATION TO SKELETAL MUSCLE OF THE DOG*

1959 • 686 citations

The concept of carrier transport and its corollaries in pharmacology.

1961 • 541 citations

The Kidney: Structure and Function in Health and Disease.

1951 • 463 citations

Some Physico-Chemical Factors in Drug Action

1957 • 396 citations

Non-ionic diffusion and the excretion of weak acids and bases

1958 • 377 citations

Physical Chemistry of Cells and Tissues

1946 • 348 citations

Active transport of Diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood

1961 • 301 citations

Passage of drugs across body membranes.

1962 • 262 citations

Secretion of organic anions in the formation of urine and bile.

1959 • 262 citations

SOME ASPECTS OF CELL PERMEABILITY TO WEAK ELECTROLYTES

1940 • 237 citations

The Distribution and Excretion of Phenobarbital1

1957 • 225 citations

STUDY OF THE PARADOXICAL EFFECTS OF SALICYLATE IN LOW, INTERMEDIATE AND HIGH DOSAGE ON THE RENAL MECHANISMS FOR EXCRETION OF URATE IN MAN *

1959 • 205 citations

Localization of Nephron Transport by Stop Flow Analysis

1958 • 192 citations

Localization of urine acidification in the mammalian kidney

1960 • 186 citations

Present knowledge of the counter-current system in the mammalian kidney

1961 • 177 citations

‘Benemid,’ p-(di-n-Propylsulfamyl)-Benzoic Acid: Its Renal Affinity and Its Elimination

1951 • 161 citations

TUBULAR SECRETION OF URATE IN MAN*

1959 • 159 citations

KINETICS OF PENETRATION OF DRUGS AND OTHER FOREIGN COMPOUNDS INTO CEREBROSPINAL FLUID AND BRAIN

1959 • 159 citations

Relationship between the lipid solubility of drugs and their oxidation by liver microsomes

1959 • 152 citations

THE MECHANISM OF THE EXCRETION OF AMMONIA IN THE DOG

1956 • 145 citations

THE RENAL MECHANISM FOR URATE EXCRETION IN MAN 1

1950 • 137 citations

Studies on the pharmacology of salicylates.

1946 • 134 citations

Physiological basis for the action of newer diuretic agents.

1961 • 122 citations

Salicylate and Salicyl Conjugates: Fluorimetric Estimation, Biosynthesis and Renal Excretion in Man1

1958 • 119 citations

Renal tubular excretion of organic bases.

1960 • 113 citations

A three-component system for regulation of renal excretion of uric acid in man.

1961 • 108 citations

Paradoxical Retention of Uric Acid by Uricosuric Drugs in Low Dosage.

1955 • 106 citations

On the mechanism of action of probenecid on renal tubular secretion.

1960 • 104 citations

RENAL TUBULAR EXCRETION

1939 • 100 citations

A drug-induced change in the distribution and renal excretion of sulfonamides.

1961 • 99 citations

The physiological disposition of probenecid, including renal clearance, in man, studied by an improved method for its estimation in biological material.

1963 • 98 citations

Mechanisms of Drug Absorption and Distribution

1961 • 90 citations

Effect of chlorothiazide on the renal excretion of uric acid

1962 • 86 citations

Distribution of drugs between blood and cerebrospinal fluid: general methodology and effect of pH gradients.

1959 • 85 citations

OBSERVATIONS CONCERNING THE CAUSES OF THE EXCESS EXCRETION OF URIC ACID IN THE DALMATIAN DOG

1948 • 80 citations

THE SECRETORY FUNCTION OF THE RENAL TUBULES

1924 • 75 citations

Tubular secretion of urate in the dog

1960 • 75 citations

Mechanisms of renal tubular transport

1958 • 73 citations

Passage of organic bases into human red cells.

1961 • 73 citations

Ciba Foundation Symposium ‐ Enzymes and Drug Action

1962 • 72 citations

The Transport of Organic Anions by the Rabbit Eye

1960 • 72 citations

A STUDY, BY SIMULTANEOUS CLEARANCE TECHNIQUES, OF SALICYLATE EXCRETION IN MAN. EFFECT OF ALKALINIZATION OF THE URINE BY BICARBONATE ADMINISTRATION; EFFECT OF PROBENECID 1

1955 • 70 citations

Active Cellular Transport of Urea by Frog Renal Tubules

1954 • 69 citations

in vitro transport of dyes by isolated renal tubules of the flounder as disclosed by direct visualization. Intracellular accumulation and transcellular movement

1958 • 68 citations

The physiological disposition of chlorothiazide (diuril) in the dog.

1959 • 68 citations

The Transport of Organic Anions by the Rabbit Eye

1960 • 66 citations

EFFECT OF ACETATE ON THE RENAL EXCRETION OF P-AMINOHIPPURATE IN THE DOG

1950 • 65 citations

Energy metabolism of the renal medulla

1961 • 65 citations

Localization of action of chlorothiazide in the nephron of the dog

1959 • 60 citations

Renal tubular secretion of creatinine in the dog

1962 • 60 citations

THE EXCRETION OF PHENOL RED BY THE DOG

1935 • 58 citations

Localization of urate transport in the nephron of mongrel and Dalmatian dog kidney

1959 • 58 citations

A study of the inverse relationship between pKa and rate of renal excretion of phenylbutazone analogs in man and dog

1960 • 58 citations

THE RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND PHYSIOLOGICAL RESPONSE

1932 • 57 citations

Studies on the renal excretion of salicylate in the dog.

1959 • 56 citations

The Prolongation of Penicillin Retention in the Body by Means of Para-Aminohippuric Acid

1944 • 54 citations

Intracellular Accumulation as an Active Process in a Mammalian Renal Transport System in Vitro

1956 • 51 citations

THE EXCRETION OF SALICYLATE

1955 • 50 citations

The mechanism of the renal excretion of oxalate in the dog.

1962 • 50 citations

Factors influencing renal excretion of foreign organic acids

1964 • 48 citations

Effect of drugs that alter uric acid excretion in man on uric acid clearance in the chicken

1960 • 48 citations

The excretion of indolylacetic acid and related indolic acids in man and the rat.

1960 • 47 citations

Absorption and renal excretion of the tetraethylammonium ion.

1947 • 46 citations

DEPRESSION OF THE EXOGENOUS CREATININE/INULIN OR THIOSULFATE CLEARANCE RATIOS IN MAN BY DIODRAST AND p-AMINOHIPPURIC ACID 1

1948 • 45 citations

Renal Elimination of 3-Methylaminoisocamphane Hydrochloride (Mecamylamine)

1956 • 44 citations

Renal Synthesis, Degradation and Active Transport of Aliphatic Acyl Amino Acids

1955 • 43 citations

Metabolic Aspects of Renal Function

1961 • 43 citations

On the Tubular Excretion of Thiosulphate and Creatinine Under the Influence of Caronamide

1949 • 41 citations

Accumulation of uric acid by slices of kidney cortex

1961 • 41 citations

Renal utilization and excretion of α-ketoglutarate in dog: effect of alkalosis

1963 • 41 citations

THE SECRETION OF PHENOL RED BY THE MAMMALIAN KIDNEY

1931 • 40 citations

Factors basic to the development of useful inhibitors of renal transport mechanisms.

1954 • 39 citations

Some effects of inorganic ions on the active transport of phenol red by isolated kidney tubules of the flounder

1952 • 39 citations

SALYRGAN AND RENAL TUBULAR SECRETION OF PARAAMINOHIPPURATE IN THE DOG AND MAN

1948 • 39 citations

Modern Views on the Secretion of Urine

1957 • 38 citations

THE INFLUENCE OF ORALLY ADMINISTERED ALKALI AND ACID ON THE RENAL EXCRETION OF QUINACRINE, CHLOROQUINE AND SANTOQUINE 1

1947 • 38 citations

Dimethylation Studies--III. The in vitro Demethylation of Dialkylmethylamines

1961 • 38 citations

Stop-flow analysis of tubular transport of uric acid in rabbits

1964 • 37 citations

Renal tubular secretion of uric acid in the mongrel dog

1960 • 37 citations

Studies on the run out of p-aminohippurate from renal slices.

1963 • 37 citations

Studies on the uptake of N'-methylnicotinamide by renal slices of the dog.

1959 • 35 citations

Modern Views on the Secretion of Urine

1957 • 34 citations

Transport of p-aminohippurate from cell to lumen in kidney tubule

1958 • 34 citations

THE RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND PHYSIOLOGICAL RESPONSE

1933 • 33 citations

Renal Excretion of Phlorizin and Phlorizin Glucuronide

1957 • 33 citations

RENAL TUBULAR SECRETION AND REABSORPTION OF ORGANIC BASES IN THE DOG*

1962 • 33 citations

Site of reabsorption of citrate and calcium in the renal tubule of the dog

1963 • 33 citations

Renal Excretion of 5,5-Dimethyl-2,4-oxazolidinedione (Product of Demethylation of Trimethadione).

1957 • 32 citations

Metabolic Aspects of Renal Function

1960 • 31 citations

Disparity Between Phenol Red and Diodrast Clearances in the Dog

1956 • 31 citations

Carbonic anhydrase inhibition. IV. The effects of metabolic acidosis on the response to diamox.

1956 • 30 citations

Concentrative transfer of an organic cation from blood into bile

1962 • 30 citations

Urinary Excretion Patterns for Substances with Simultaneous Secretion and Reabsorption by Active Transport

1961 • 29 citations

Effects of probenecid, sodium salicylate, 2,4-dinitrophenol and pyrazinamide on renal secretion of uric acid in chickens.

1959 • 29 citations

Renal tubular transport of Diodrast-I¹³¹ and PAH in Necturus: evidence for simultaneous reabsorption and secretion

1959 • 29 citations

Inhibition of the renal tubular excretion of tetraethylammonium and N'-methylnicotinamide by basic cyanine dyes.

1956 • 29 citations

Stop-flow analysis of creatinine excretion in the dog

1962 • 28 citations

Renal excretion of nitrofurantoin (Furadantin)

1959 • 28 citations

The renal tubular excretion of choline and thiamine in the chicken.

1958 • 27 citations

Kinetics of p-aminohippurate secretion in the rabbit

1963 • 26 citations

Competitive inhibition and specificity of renal tubular transport mechanisms.

1954 • 26 citations

Stop-flow localization of renal tubular excretion of tetraethylammonium

1960 • 25 citations

The renal clearance of barbital and the mechanism of its reabsorption.

1951 • 25 citations

INTESTINAL ABSORPTION OF BILE SALTS AND SOME BIOLOGICAL IMPLICATIONS.

1963 • 25 citations

THE RELATION BETWEEN CHEMICAL STRUCTURE AND PHYSIOLOGICAL DISPOSITION OF A SERIES OF SUBSTANCES ALLIED TO SULFANILAMIDE

1943 • 25 citations

Renal tubular secretion of tetraethylammonium in the dog and the chicken.

1954 • 24 citations

Excretion of para‐aminohippurate by the kidney of the cat

1949 • 23 citations

Renal excretion of choline in the dog

1962 • 23 citations

Transport of phenolsulfonphthalein dyes in isolated tubules of the flounder and in kidney slices of the dogfish. Competitive phenomena

1954 • 22 citations

Tubular Excretion of Creatinine in the Rat

1952 • 22 citations

Renal tubular transport of nitrofurantoin

1962 • 22 citations

Effects of tubular secretion and reabsorption on titration curves of tubular transport

1961 • 22 citations

Autoradiographic study of Diodrast-I¹³¹ transport in Necturus kidney

1960 • 22 citations

Renal Tubular Secretion of Sulfonamides and p‐Aminobenzoic Acid

1945 • 22 citations

Exchange diffusion and runout of Diodrast-I¹³¹ from renal tissue in vitro

1961 • 22 citations

The excretion of piperidine, guanidine, methylguanidine and N1-methylnicotinamide in the chicken.

1949 • 21 citations

OBSERVATIONS ON THE BEHAVIOR OF DIODRAST IN THE DOG

1940 • 21 citations

The renal excretion of phenol red by the aglomerular fishes, Opsanus tau and Lophius piscatorius

1938 • 21 citations

On the Renal Excretion of Salicylate.

1951 • 21 citations

Urinary excretion by nonionic diffusion

1959 • 20 citations

Conjugation and excretion of the amino and acetamido benzoic acids

1959 • 20 citations

Molecular features of sulfonamide transport in renal excretory processes

1962 • 20 citations

THE REMOVAL OF DIODRAST FROM BLOOD BY THE DOG'S EXPLANTED KIDNEY

1941 • 20 citations

Use of Thiosulfate Clearance As a Measure of Glomerular Filtration Rate in Acidotic Dogs.

1947 • 19 citations

Displacement Characteristics of Intracellularly Accumulated p-Aminohippurate in a Mammalian Renal Transport System in Vitro

1958 • 19 citations

Renal disposal of salicyluric acid

1962 • 17 citations

Renal Clearance in Dogs with Regard to Variations According to Age and Sex

1961 • 17 citations

Studies on Elimination of Procaine. III. Determination of the Renal Clearance of Procaine and p‐Aminobenzoic Acid in Dog and Rabbit.

1951 • 17 citations

Biochemorphology of renal tubular transport: hippuric acid and related substances.

1959 • 16 citations

Urinary and biliary excretion of dyes in acidosis and alkalosis in the dog

1962 • 16 citations

Modification by Bromcresol Green or Probenecid of the Excretion and Diuretic Effect of three Mercurial Diuretics, Diurgin®, Chlormerodrin and Mercumatilin.

1960 • 16 citations

Pharmacology of benzydroflumethiazide (Naturetin).

1961 • 15 citations

Glomerular and Tubular Functions in Sheep and Goats

1957 • 15 citations

Tubular Excretion of Serotonin (5-Hydroxytryptamine) in the Chicken

1962 • 15 citations

Renal Secretion of Thiosulfate in the Dog

1951 • 15 citations

Studies of the renal tubular transport characteristics of N1-methylnicotinamide and tetraalkylammonium compounds in the avian kidney.

1959 • 14 citations

The renal clearance of pantothenic acid in man

1951 • 14 citations

Conjugation of p-Aminohippurate by the Kidney and Effective Renal Plasma-flow

1961 • 14 citations

Run‐out of chlorphenol red following luminal accumulation by isolated renal tubules of the flounder in vitro

1958 • 13 citations

Renal tubular excretion studies with pyrimidine derivatives and analogs.

1962 • 13 citations

Some Characteristics of the Renal Tubular Transport Mechanism for Histamine in the Hen

1958 • 13 citations

Renal Tubular Function During Severe Metabolic Acidosis

1954 • 12 citations

Competitive inhibition of renal transport of p-aminohippurate by other mono-substituted hippurates

1960 • 12 citations

Renal tubular transport of citrate: relations with calcium

1963 • 12 citations

Reabsorption and secretion of ι-malic acid in kidney proximal tubule

1962 • 12 citations

The first common pathway.

1960 • 11 citations

Renal Excretion of Sulphathiazole and Sulphadimidine in Pigs.

1956 • 11 citations

Renal Clearance of Pantothenic Acid in Man: Inhibition by Probenecid ('Benemid').

1953 • 11 citations

Renal tubular transport and molecular structure in the acetamidobenzoic acids.

1961 • 11 citations

Stop-flow analyses of mepiperphenidol and mecamylamine in the dog

1963 • 11 citations

INHIBITION OF THE RENAL TUBULAR EXCRETION OF N1-METHYLNICOTINAMIDE (NMN) IN THE AVIAN KIDNEY BY A CYANINE DYE AND BY BISQUATERNARY COMPOUNDS

1960 • 11 citations

CARINAMIDE (4'-CARBOXYPHENYLMETHANESULFONANILIDE): ITS RENAL CLEARANCE AND BINDING ON PLASMA PROTEIN

1949 • 11 citations

Renal excretion of para-aminosalicylic acid: a two-way transport system in the dog

1960 • 11 citations

Fate of Gentisic Acid in Man as Influenced by Alkalinization and Acidification

1953 • 11 citations

Binding of Some Sulfonphthalein Dyes to Plasma Protein of Various Species

1960 • 10 citations

The Effects of D‐ and L‐lactate and Osmotic Diuretics on Uric Acid Clearance in the Rabbit

1962 • 10 citations

Renal excretion of thiamin by the dog

1960 • 10 citations

The transport of priscoline by the renal tubules.

1953 • 9 citations

Studies on the renal tubular secretion of N1-methylnicotinamide.

1961 • 9 citations

Relation of rate of excretion of salicylate to urinary acidity.

1951 • 8 citations

RENAL TUBULAR TRANSPORT RELATIONSHIPS BETWEEN N1-METHYLNICOTINAMIDE (NMN), MECAMYLAMINE, QUININE, QUINIDINE AND QUINACRINE IN THE AVIAN KIDNEY

1960 • 8 citations

Localization of the renal mechanisms of excretion of mecamylamine and indolylacetic acid in the dog.

1961 • 8 citations

168 Renal excretion of weak organic acids and bases

1961 • 8 citations

Effect of Phenylbutazone (Butazolidin) on Renal Excretion of P-Aminohippurate and Thiosulfate in the Dog.

1953 • 7 citations

Influence of analogues of phenylbutazone on renal transport of 4-aminohippurate

1963 • 7 citations

Tubular Transport Maxima of PAH and Diodrast Measured Individually in the Aglomerular Kidney of Lophius, and Simultaneously as Competitors Under Conditions of Equimolar Loading

1962 • 6 citations

Inhibition of the renal tubular transport of N1-methylnicotinamide (NMN) by 1,1-dialkylpiperidinium compounds in the avian kidney.

1959 • 6 citations

Observations concerning the renal tubular transport characteristics of three quarternary bases in dogs.

1957 • 6 citations

Renal Tubular Transport of Some Nitro and Amino Hippuric Acids.

1962 • 5 citations

Renal tubular secretion of o-acetylaminohippurate

1962 • 5 citations

Kinetic Studies on the Competition Between Para-aminohippuric Acid(PAH) and Diodrast for Renal Trnsport in the Dog

1960 • 5 citations

Secretion of 2,7‐Naphthalenedisulphonic Acid in the Chicken's Renal Tubules

1962 • 5 citations

Comparison between effects of carinamide and probenecid on thiosulphate secretion in the renal tubules of the dog.

1962 • 2 citations

Effect of bio-electric potentials on absorption and distribution of organic electrolytes.

1962 • 1 citations