Genetic and epigenetic control of early mouse development

Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

2005 • 4,388 citations

Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

2000 • 3,564 citations

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

1998 • 3,360 citations

The ground state of embryonic stem cell self-renewal

2008 • 3,292 citations

Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells

2003 • 3,230 citations

The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells

2003 • 3,179 citations

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

2006 • 2,414 citations

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

2006 • 2,241 citations

Nanog safeguards pluripotency and mediates germline development

2007 • 1,472 citations

Demethylation of the zygotic paternal genome

2000 • 1,292 citations

Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation

2005 • 1,160 citations

Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

2005 • 1,077 citations

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

2008 • 954 citations

Early Lineage Segregation between Epiblast and Primitive Endoderm in Mouse Blastocysts through the Grb2-MAPK Pathway

2006 • 877 citations

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

2008 • 864 citations

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

2008 • 811 citations

FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment

2007 • 784 citations

How is pluripotency determined and maintained?

2007 • 780 citations

The protamine family of sperm nuclear proteins

2007 • 687 citations

The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

2007 • 677 citations

Genomic Imprinting Disrupted by a Maternal Effect Mutation in the Dnmt1 Gene

2001 • 675 citations

Chromatin dynamics during epigenetic reprogramming in the mouse germ line

2008 • 653 citations

Dynamic Equilibrium and Heterogeneity of Mouse Pluripotent Stem Cells with Distinct Functional and Epigenetic States

2008 • 637 citations

Histone arginine methylation regulates pluripotency in the early mouse embryo

2007 • 578 citations

Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b

2006 • 543 citations

Epigenetic reprogramming and induced pluripotency

2009 • 539 citations

PGC7/Stella protects against DNA demethylation in early embryogenesis

2006 • 535 citations

Differentiation of embryonic stem cells is induced by GATA factors

2002 • 530 citations

Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development

2007 • 502 citations

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

2007 • 499 citations

Stochastic patterning in the mouse pre-implantation embryo

2007 • 497 citations

The molecular foundations of the maternal to zygotic transition in the preimplantation embryo

2002 • 467 citations

Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos

2007 • 461 citations

Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development

2008 • 456 citations

The transcription factor GATA6 is essential for early extraembryonic development

1999 • 444 citations

Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice

2007 • 424 citations

Transcript profiling during preimplantation mouse development

2004 • 408 citations

Dynamic chromatin modifications characterise the first cell cycle in mouse embryos

2005 • 388 citations

Global Mapping of DNA Methylation in Mouse Promoters Reveals Epigenetic Reprogramming of Pluripotency Genes

2008 • 347 citations

Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5

2008 • 341 citations

Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo

2007 • 332 citations

Asymmetry in Histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote

2005 • 324 citations

Polycomb Repressive Complex 2 Is Dispensable for Maintenance of Embryonic Stem Cell Pluripotency

2008 • 322 citations

Nuclear Transplantation, Embryonic Stem Cells, and the Potential for Cell Therapy

2003 • 321 citations

Maternal BRG1 regulates zygotic genome activation in the mouse

2006 • 321 citations

PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos

2008 • 310 citations

Polycomb Group Proteins Ezh2 and Rnf2 Direct Genomic Contraction and Imprinted Repression in Early Mouse Embryos

2008 • 306 citations

Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity

2008 • 292 citations

Dynamic Reprogramming of DNA Methylation at an Epigenetically Sensitive Allele in Mice

2006 • 244 citations

Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo

2008 • 240 citations

Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos

2006 • 237 citations

Isolation of four core histones from human sperm chromatin representing a minor subset of somatic histones

1990 • 236 citations

Four-cell stage mouse blastomeres have different developmental properties

2005 • 234 citations

Regulation of histone H3 lysine 9 methylation in oocytes and early pre-implantation embryos

2004 • 219 citations

Lineage allocation and cell polarity during mouse embryogenesis

2004 • 218 citations

Dynamic alterations of specific histone modifications during early murine development

2004 • 206 citations

Sperm-derived histones contribute to zygotic chromatin in humans

2008 • 178 citations

Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells

2007 • 177 citations

Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: Expression of Cdx2 and Oct4 and developmental potential of inner and outer blastomeres of 16- and 32-cell embryos

2008 • 174 citations

Modifiers of epigenetic reprogramming show paternal effects in the mouse

2007 • 168 citations

Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos

2008 • 155 citations

Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells

2006 • 127 citations

Ubiquitin E3 Ligase Ring1b/Rnf2 of Polycomb Repressive Complex 1 Contributes to Stable Maintenance of Mouse Embryonic Stem Cells

2008 • 115 citations

A Novel and Critical Role for Oct4 as a Regulator of the Maternal-Embryonic Transition

2008 • 110 citations