Endothelial Regulation of Vascular Tone and Growth

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Influence of the Internal-Mammary-Artery Graft on 10-Year Survival and Other Cardiac Events

1986 • 2,691 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Flow-induced release of endothelium-derived relaxing factor

1986 • 1,379 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

1990 • 1,190 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.

1990 • 803 citations

Endothelium‐dependent hyperpolarization of canine coronary smooth muscle

1988 • 785 citations

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

1990 • 596 citations

The Endothelium: Modulator of Cardiovascular Function

2020 • 543 citations

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

1987 • 534 citations

Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?

1990 • 446 citations

Divergent Effects of Serotonin on Coronary-Artery Dimensions and Blood Flow in Patients with Coronary Atherosclerosis and Control Patients

1991 • 420 citations

Superoxide anion is an endothelium-derived contracting factor

1989 • 398 citations

Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium.

1992 • 357 citations

Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis.

1989 • 357 citations

Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery.

1990 • 312 citations

Endothelin is a potent secretagogue for atrial natriuretic peptide in cultured rat atrial myocytes

1988 • 299 citations

Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.

1990 • 297 citations

Imbalance of Endothelium-derived Relaxing and Contracting Factors: A New Concept in Hypertension?

1990 • 243 citations

Structure-activity relationships of endothelin: Importance of the C-terminal moiety

1988 • 220 citations

Age and hypertension promote endothelium-dependent contractions to acetylcholine in the aorta of the rat.

1989 • 219 citations

Endothelium-derived relaxant factor inhibits platelet activation

1987 • 195 citations

Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein.

1991 • 194 citations

Incubation with endotoxin activates the L-arginine pathway in vascular tissue

1990 • 193 citations

Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor.

1991 • 190 citations

Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide

1990 • 183 citations

Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle.

1990 • 152 citations

Atrial natriuretic peptide, nitroglycerine, and nitroprusside reduce basal and stimulated endothelin production from cultured endothelial cells

1990 • 148 citations

Endothelin in hypertensive resistance arteries. Intraluminal and extraluminal dysfunction.

1991 • 122 citations

Endothelial Cells Synthesize Basic Fibroblast Growth Factor and Transforming Growth Factor Beta

1988 • 119 citations

Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries

1990 • 109 citations

Specific binding of endothelin on human vascular smooth muscle cells in culture.

1989 • 103 citations

Synergistic inhibition of platelet aggregation by endothelium derived relaxing factor and prostacyclin

1988 • 99 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 94 citations

Aging differentially affects direct and indirect actions of endothelin‐1 in perfused mesenteric arteries of the rat

1990 • 79 citations

Endothelin-3 regulates endothelin-1 production in cultured human endothelial cells.

1991 • 78 citations

Different Mobilization of Calcium in Endothelin-1 -Induced Contractions in Human Arteries and Veins: Effects of Calcium Antagonists

1990 • 74 citations

Mechanism of contraction to endothelin in isolated porcine coronary artery

1989 • 71 citations

Immunoreactive Endothelin-1 in Plasma Detected by a Sandwich-Type Enzyme Immunoassay

1989 • 59 citations

Release of nitric oxide from human vascular smooth muscle cells

1991 • 51 citations

Endothelin release is inhibited by coculture of endothelial cells with cells of vascular media

1990 • 50 citations

Similar endothelium-dependent relaxation, but enhanced contractility, of the right gastroepiploic artery as compared with the internal mammary artery

1992 • 35 citations

Endothelium-Derived Contracting Factors

1992 • 30 citations

Endothelium, lipoproteins and atherosclerotic vascular disease

1991 • 12 citations