Fibrinogen binding to purified platelet glycoprotein IIb-IIIa (integrin alpha IIb beta 3) is modulated by lipids.

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T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 1,031 citations

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Exposure of platelet fibrinogen receptors by ADP and epinephrine.

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The platelet membrane glycoprotein IIb-IIIa complex

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1966 • 821 citations

A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa.

1983 • 780 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

Human platelets possess an inducible and saturable receptor specific for fibrinogen.

1979 • 713 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.

1985 • 594 citations

Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)

1991 • 481 citations

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin”.

1987 • 466 citations

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

1987 • 428 citations

A β ₃ Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation

1990 • 418 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Modulation of the Affinity of Integrin α _IIb β ₃ (GPIIb-IIIa) by the Cytoplasmic Domain of α _IIb

1991 • 322 citations

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

1990 • 285 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

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1984 • 257 citations

Evidence that three adhesive proteins interact with a common recognition site on activated platelets.

1984 • 254 citations

An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2.

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Induction of the fibrinogen receptor on human platelets by intracellular mediators.

1987 • 240 citations

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1980 • 209 citations

Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes.

1986 • 206 citations

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

1990 • 204 citations

Membrane Fluidity in Biology

1985 • 192 citations

Modulation of vitronectin receptor binding by membrane lipid composition.

1990 • 180 citations

Calcium regulation of the platelet membrane glycoprotein IIb-IIIa complex.

1985 • 178 citations

Quantitation of membrane glycoprotein IIIa on intact human platelets using the monoclonal antibody, AP-3

1985 • 175 citations

A calcium-activated polyphosphoinositide phosphodiesterase in the plasma membrane of human and rabbit erythrocytes

1978 • 174 citations

Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins

1992 • 163 citations

Reconstitution of the purified platelet fibrinogen receptor. Fibrinogen binding properties of the glycoprotein IIb-IIIa complex.

1985 • 158 citations

[1] Isolation of human platelets from plasma by centrifugation and washing

1989 • 131 citations

Arachidonate release and phosphatidic acid turnover in stimulated human platelets.

1983 • 126 citations

A method for purifying the platelet membrane glycoprotein IIb-IIIa complex

1985 • 121 citations

Thrombin stimulates the production of a novel polyphosphoinositide in human platelets.

1990 • 107 citations

Effect of calcium on the stability of the platelet membrane glycoprotein IIb-IIIa complex.

1985 • 105 citations

The Role of Endogenously Formed Diacylglycerol in the Propagation and Termination of Platelet Activation

1989 • 98 citations

Phorbol ester treatment of intact rabbit platelets greatly enhances both the basal and guanosine 5′-[γ-thio]triphosphate-stimulated phospholipase D activities of isolated platelet membranes. Physiological activation of phospholipase D may be secondary to activation of phospholipase C

1990 • 90 citations

Elevated cytosolic Ca2+ activates phospholipase D in human platelets

1991 • 90 citations

Expression of recombinant platelet glycoprotein IIbIIIa results in a functional fibrinogen-binding complex

1989 • 90 citations

Second messenger function of phosphatidic acid in platelet activation

1989 • 86 citations

Fibrinogen binding to human platelet plasma membranes. Identification of two steps requiring divalent cations.

1983 • 86 citations

Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets?

1982 • 84 citations

Phosphorylation of human platelet glycoprotein IIIa (GPIIIa). Dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro

1991 • 75 citations

Prostaglandin endoperoxide analogues stimulate phospholipase C and protein phosphorylation during platelet shape change

1985 • 71 citations

A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties.

1990 • 61 citations

Platelet membrane glycoprotein IIb-IIIa complex incorporated into phospholipid vesicles. Preparation and morphology.

1985 • 60 citations

Methods in inositide research

1991 • 60 citations

ADP-Induced changes in [32P]phosphate labeling of phosphatidylinositol-4,5-bisphosphate in washed rabbit platelets made refractory by prior ADP stimulation

1983 • 25 citations