Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial "stunning" in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects.

Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent

1968 • 7,671 citations

The Analysis of Variance

1960 • 5,685 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Some statistical methods useful in circulation research.

1980 • 3,978 citations

Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.

1975 • 1,004 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

The Biochemistry of Desferrioxamine and its Relation to Iron Metabolism

1964 • 620 citations

Myocardial 'stunning' in man.

1992 • 531 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?

1989 • 385 citations

Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro.

1984 • 328 citations

The oxygen free radical system: A fundamental mechanism in the production of myocardial necrosis

1986 • 236 citations

Use of desferrioxamine as a ‘probe’ for iron-dependent formation of hydroxyl radicals

1985 • 188 citations

Reactions of ferrioxamine and desferrioxamine with the hydroxyl radical

1982 • 151 citations

Prolonged abnormalities of left ventricular diastolic wall thinning in the “stunned” myocardium in conscious dogs: Time course and relation to systolic function

1989 • 134 citations

Postischemic Myocardial "Stunning": A Clinically Relevant Phenomenon

1988 • 133 citations

Coronary artery disease in cardiac transplant patients receiving triple-drug immunosuppressive therapy.

1989 • 123 citations

N-2-Mercaptopropionylglycine improves recovery of myocardial function after reversible regional ischemia

1986 • 115 citations

The enzymatic oxidation of Desferal to a nitroxide free radical

1987 • 111 citations

Effects of anesthesia and sleep on circulatory response to carotid sinus nerve stimulation

1971 • 109 citations

Demonstration of free radical generation in the "stunned" myocardium in the conscious dog and identification of major differences between conscious and open-chest dogs.

1993 • 109 citations

Use of Spin Traps in Intact Animals Undergoing Myocardial Ischemia/Reperfusion: A New Approach to Assessing the Role of Oxygen Radicals in Myocardial “Stunning”

1990 • 76 citations

Effects of cardiac depression and of anesthesia on the myocardial action of a cardiac glycoside

1971 • 73 citations

Desferrioxamine as an Electron Donor. Inhibition of Membranal Lipid Peroxidation Initiated by H₂0₂–Activated Metmyoglobin and Other Peroxidizing Systems

1987 • 71 citations

On the Specificity of Allopurinol and Oxypurinol as Inhibitors of Xanthine Oxidase. A Pulse Radiolysis Determination of Rate Constants for Reaction of Allopurinol and Oxypurinol with Hydroxyl Radicals

1988 • 59 citations

Protection Against Postischemic Myocardial Dysfunction in Anesthetized Rabbits with Scavengers of Oxygen-Derived Free Radicals

1991 • 54 citations

Inhibition of peroxidase-catalyzed reactions by deferoxamine

1988 • 37 citations

Tiopronin (n-[2-mercaptopropionyl] glycin) in rheumatoid arthritis

1982 • 37 citations

Effects of Hydroxyethyl Starch Conjugated Deferoxamine on Myocardial Functional Recovery Following Coronary Occlusion and Reperfusion in Dogs

1991 • 34 citations

Effect of Tiopronin on Senile Cataracts

1980 • 28 citations

Disparity of reperfusion arrhythmias after reversible myocardial ischemia in open chest and conscious dogs

1986 • 27 citations

Different Relations Between Infarct Size and Occluded Bed Size in Barbiturate-Anesthetized Versus Conscious Dogs

1985 • 23 citations

Therapeutic Effects of Tiopronin on Chronic Hepatitis: A Double-Blind Clinical Study

1982 • 18 citations

Ejection- and isovolumic contraction-phase wall thickening in nonischemic myocardium during coronary occlusion

1990 • 17 citations