Novel indices of oxidant stress in cardiovascular disease: specific analysis of F2-isoprostanes

Beyond Cholesterol

1989 • 6,533 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

Regular physical exercise and low-fat diet. Effects on progression of coronary artery disease.

1992 • 1,349 citations

Increase in Circulating Products of Lipid Peroxidation (F₂-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage

1995 • 1,343 citations

Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea

1993 • 1,142 citations

Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids.

1992 • 742 citations

Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers

1996 • 621 citations

Invited Review Free Radicals in Disease Processes: A Compilation of Cause and Consequence

1993 • 581 citations

Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues.

1989 • 518 citations

Protective role of vitamin E in biological systems

1991 • 515 citations

Autoxidation of polyunsaturated fatty acids: II. A suggested mechanism for the formation of TBA‐reactive materials from prostaglandin‐like endoperoxides

1976 • 512 citations

Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors.

1992 • 510 citations

Noncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoids

1990 • 480 citations

Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease.

1983 • 464 citations

The isoprostanes

1996 • 451 citations

Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes.

1987 • 392 citations

Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation.

1992 • 319 citations

Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes.

1994 • 305 citations

[2] Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection

1994 • 303 citations

11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation.

1986 • 281 citations

8-Epi PGF _2α Generation During Coronary Reperfusion

1997 • 272 citations

Cylooxygenase-dependent Formation of the Isoprostane, 8-Epi Prostaglandin F2α

1995 • 262 citations

Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro.

1994 • 248 citations

[16] Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism

1994 • 225 citations

Local Amplification of Platelet Function by 8-Epi Prostaglandin F2α Is Not Mediated by Thromboxane Receptor Isoforms

1996 • 205 citations

Paired analysis of urinary thromboxane B2 metabolites in humans

1987 • 200 citations

Increased production of oxygen free radicals in cigarette smokers.

1991 • 199 citations

Generation of 8-Epiprostaglandin F by Human Monocytes

1996 • 189 citations

Oxidative DNA damage correlates with oxygen consumption in humans

1994 • 182 citations

Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator.

1989 • 180 citations

Aspects to Consider When Detecting and Measuring Lipid Peroxidation

1986 • 172 citations

Increased thromboxane biosynthesis during coronary thrombolysis. Evidence that platelet activation and thromboxane A2 modulate the response to tissue-type plasminogen activator in vivo.

1989 • 171 citations

Identification of the Major Urinary Metabolite of the F2-isoprostane 8-Iso-prostaglandin F2α in Humans

1996 • 159 citations

Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein.

1990 • 153 citations

Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator.

1989 • 130 citations

Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress.

1993 • 130 citations

Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ

1992 • 127 citations

8-Epi PGF_2α : specific analysis of an isoeicosanoid as an index of oxidant stress in vivo

1996 • 123 citations

Stereochemical course of the autooxidative cyclization of lipid hydroperoxides to prostaglandin-like bicyclic endoperoxides

1984 • 120 citations

Nonenzymatic Free Radical-catalyzed Generation of Thromboxane-like Compounds (Isothromboxanes) in Vivo

1996 • 117 citations

Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: Inhibition by CuZn-SOD

1993 • 114 citations

Lipid peroxidation associated with successful thrombolysis

1990 • 101 citations

Isoleukotrienes Are Biologically Active Free Radical Products of Lipid Peroxidation

1995 • 100 citations

Comparative study on the effect of low-dose vitamin E and probucol on the susceptibility of LDL to oxidation and the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.

1994 • 92 citations

Antiaggregatory activity of 8-epi-prostaglandin F2 alpha and other F-series prostanoids and their binding to thromboxane A2/prostaglandin H2 receptors in human platelets.

1994 • 69 citations

Formation of F₂‐isoprostanes during aortic endothelial cell‐mediated oxidation of low density lipoprotein

1994 • 63 citations

Mass spectrometric analysis of four regioisomers of F₂-isoprostanes formed by free radical oxidation of arachidonic acid

1996 • 63 citations

Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase

1987 • 62 citations

Total synthesis of a novel isoprostane IPF2α-I and its identification in biological fluids

1996 • 56 citations

Free radical biology and medicine

2003 • 55 citations

Human β-Cell Glucokinase

1995 • 52 citations

Oxidative damage to the myocardium: a fundamental mechanism of myocardial injury.

1991 • 41 citations

Measurement of Lipid Hydroperoxides in Normal Human Blood Plasma Using HPLC-Chemiluminescence Linked to a Diode Array Detector for Measuring Conjugated Dienes

1991 • 40 citations

Spin Trapping and Associated Vocabulary

1990 • 31 citations

Comparison of effects of probucol versus vitamin E on ex vivo oxidation susceptibility of lipoproteins in hyperlipoproteinemia

1994 • 24 citations

α-2,6-Difluorophenyl-N-Tert-Butylnitrone: A Spin Trap for Distinguishing Different Types of Alkyl Radicals Based on Long-Range Fluorine Hyperfine Splitting

1990 • 11 citations

Alternating current polarographic investigation of polysaccharides in DNA

1978 • 4 citations