Free radical biology and medicine

ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

2007 • 3,267 citations

Signal transduction by reactive oxygen species

2011 • 2,100 citations

Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

2005 • 1,373 citations

Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

2003 • 1,317 citations

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

2008 • 1,221 citations

Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation

2005 • 1,033 citations

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

2003 • 926 citations

A Thiol Peroxidase Is an H2O2 Receptor and Redox-Transducer in Gene Activation

2002 • 875 citations

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

2008 • 746 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

Functional antioxidant responsive elements

1997 • 702 citations

Peroxynitrite reductase activity of bacterial peroxiredoxins

2000 • 673 citations

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

2001 • 639 citations

Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation bytert-Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult

2004 • 528 citations

Nrf2, a multi‐organ protector?

2005 • 520 citations

Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches

2009 • 462 citations

Inactivation of Human Peroxiredoxin I during Catalysis as the Result of the Oxidation of the Catalytic Site Cysteine to Cysteine-sulfinic Acid

2002 • 449 citations

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

2002 • 338 citations

Phosphatidylinositol 3-Kinase Regulates Nuclear Translocation of NF-E2-Related Factor 2 through Actin Rearrangement in Response to Oxidative Stress

2002 • 269 citations

Stimulation of autophagy by the p53 target gene Sestrin2

2009 • 264 citations

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

1999 • 241 citations

Nrf2: control of sensitivity to carcinogens

2011 • 213 citations

Cooperation of Yeast Peroxiredoxins Tsa1p and Tsa2p in the Cellular Defense against Oxidative and Nitrosative Stress

2002 • 172 citations

Irreversible Oxidation of the Active-site Cysteine of Peroxiredoxin to Cysteine Sulfonic Acid for Enhanced Molecular Chaperone Activity

2008 • 172 citations

Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells

2007 • 135 citations

Glucocorticoid Receptor (GR)-Associated SMRT Binding to C/EBPβ TAD and Nrf2 Neh4/5: Role of SMRT Recruited to GR in GSTA2 Gene Repression

2005 • 133 citations

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse

2003 • 108 citations

Sestrin 2 Is Not a Reductase for Cysteine Sulfinic Acid of Peroxiredoxins

2008 • 95 citations

Role of sestrin2 in peroxide signaling in macrophages

2009 • 84 citations

Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response

2008 • 59 citations