Early ovarian cancer: A review of its genetic and biologic factors, detection, and treatment

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

A Radioimmunoassay Using a Monoclonal Antibody to Monitor the Course of Epithelial Ovarian Cancer

1983 • 2,102 citations

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

1994 • 1,884 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

1995 • 1,602 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

1993 • 1,269 citations

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

1994 • 1,205 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

INCESSANT OVULATION—A FACTOR IN OVARIAN NEOPLASIA ?

1971 • 1,104 citations

Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 US Case -Control Studies

1992 • 995 citations

Cancer statistics, 1993

1993 • 983 citations

Principles and Practice of Gynecologic Oncology

1992 • 933 citations

Antioncogenes and human cancer.

1993 • 772 citations

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.

1990 • 763 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

Ovarian Tumors in a Cohort of Infertile Women

1994 • 706 citations

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

1994 • 626 citations

Adjuvant Therapy in Stage I and Stage II Epithelial Ovarian Cancer

1990 • 571 citations

A Comprehensive Human Linkage Map with Centimorgan Density

1994 • 547 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Familial breast-ovarian cancer locus on chromosome 17q12-q23

1991 • 513 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 US Case-Control Studies

1992 • 507 citations

Staging Laparotomy in Early Ovarian Cancer

1983 • 479 citations

Overexpression and mutation of p53 in epithelial ovarian cancer.

1991 • 464 citations

Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome

1992 • 414 citations

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

1994 • 389 citations

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

1995 • 377 citations

Prevalence screening for ovarian cancer in postmenopausal women by CA 125 measurement and ultrasonography.

1993 • 371 citations

[Prognostic factors in patients with stage I epithelial ovarian cancer].

1994 • 353 citations

Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

1994 • 334 citations

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening

1995 • 329 citations

Tubal Ligation, Hysterectomy, and Risk of Ovarian Cancer

1993 • 321 citations

Risk factors for ovarian cancer: a case-control study

1989 • 304 citations

Transvaginal colour flow imaging: a possible new screening technique for ovarian cancer.

1989 • 302 citations

p53 gene mutations and protein accumulation in human ovarian cancer.

1993 • 294 citations

Genetic basis for p53 overexpression in human breast cancer.

1991 • 287 citations

An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.

1995 • 268 citations

Allelotype of human ovarian cancer.

1991 • 257 citations

Transvaginal ultrasonographic characterization of ovarian masses with an improved, weighted scoring system

1994 • 254 citations

Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy.

1993 • 238 citations

Overexpression and mutation of p53 in endometrial carcinoma.

1992 • 227 citations

Preoperative evaluation of serum CA 125 levels in premenopausal and postmenopausal patients with pelvic masses. Discrimination of benign from malignant disease

1988 • 226 citations

p53 and Ki-ras gene mutations in epithelial ovarian neoplasms.

1993 • 216 citations

The epidemiology of ovarian cancer

1991 • 214 citations

A case-control study of epithelial ovarian cancer

1989 • 213 citations

Elevation of Multiple Serum Markers in Patients With Stage I Ovarian Cancer

1993 • 198 citations

A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis

1994 • 195 citations

Prognostic significance of dna index, multiploidy, and S-phase fraction in ovarian cancer

1988 • 194 citations

Frequent allelic losses and mutations of the p53 gene in human ovarian cancer.

1991 • 194 citations

Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM region on 17q21.3 often and commonly deleted in tumors.

1993 • 192 citations

Frequent loss of heterozygosity on chromosomes 6q, 11, and 17 in human ovarian carcinomas.

1990 • 189 citations

Spectrum of Mutation and Frequency of Allelic Deletion of the p53 Gene in Ovarian Cancer

1993 • 184 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer

1991 • 173 citations

Ovarian cancer screening

1995 • 170 citations

Mutation and overexpression of p53 in early-stage epithelial ovarian cancer.

1993 • 168 citations

Misstaging of ovarian cancer.

1985 • 168 citations

Cancer mortality among Japanese ISSEI and NISEI of California

1965 • 160 citations

Differentiating Malignant From Benign Ovarian Tumors With Transvaginal Color Flow Imaging

1992 • 158 citations

Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q

1994 • 158 citations

Clonal Origin of Epithelial Ovarian Carcinoma: Analysis by Loss of Heterozygosity, p53 Mutation, and X-Chromosome Inactivation

1992 • 157 citations

Factors influencing survival in Stage I ovarian cancer

1973 • 156 citations

p53 mutations in ovarian cancer: a late event?

1991 • 151 citations

Transvaginal Color Doppler For The Assessment Of Pelvic Circulation

1989 • 148 citations

Limited contribution of Doppler velocimetry to the differential diagnosis of extrauterine pelvic tumors.

1994 • 144 citations

Epithelial Ovarian Cancer and Combination Oral Contraceptives

1982 • 137 citations

Morphologic precursors of ovarian epithelial tumors.

1993 • 133 citations

Analysis of prognostic factors in stage I epithelial ovarian carcinoma: Importance of degree of differentiation and deoxyribonucleic acid ploidy in predicting relapse

1993 • 130 citations

c-myc amplification in ovarian cancer

1990 • 127 citations

Ultrasound screening for familial ovarian cancer

1991 • 126 citations

DISTINCTION OF BENIGN FROM MALIGNANT OVARIAN CYSTS BY ULTRASOUND

1978 • 118 citations

Contralateral Ovary in Unilateral Ovarian Carcinoma

1993 • 116 citations

Incidence of ovarian cancer in relation to the use of oral contraceptives

1981 • 113 citations

Surgical staging and cytoreductive surgery of epithelial ovarian cancer

1993 • 112 citations

Comparison between sonographic morphology and Doppler waveform for the diagnosis of ovarian malignancy.

1994 • 111 citations

Transvaginal Doppler Ultrasound With Color Flow Imaging in the Diagnosis of Ovarian Cancer

1992 • 109 citations

p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry.

1992 • 109 citations

Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification.

1991 • 108 citations

A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus.

1993 • 105 citations

Prognostic factors for survival in Stage I epithelial ovarian carcinoma

1990 • 105 citations

Fine-scale deletion mapping of the distal long arm of chromosome 6 in 70 human ovarian cancers.

1992 • 103 citations

Allelic loss in ovarian cancer

1993 • 100 citations

The estimated effect of oral contraceptive use on the cumulative risk of epithelial ovarian cancer.

1994 • 99 citations

Staging laparotomy in early ovarian cancer

1983 • 96 citations

Early stage ovarian cancer: a randomized clinical trial comparing whole abdominal radiotherapy, melphalan, and intraperitoneal chromic phosphate: a National Cancer Institute of Canada Clinical Trials Group report.

1988 • 95 citations

AN EPIDEMIOLOGIC CASE-CONTROL STUDY OF OVARIAN CANCER AND REPRODUCTIVE FACTORS

1984 • 95 citations

Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance on 9q and rare alterations involving 9p, including CDKN2.

1995 • 95 citations

All in the (cancer) family

1993 • 93 citations

Sonographic accuracy in the diagnosis of ovarian masses.

1990 • 92 citations

Postoperative treatment of early cancer of the ovary: a random trial between postoperative irradiation and chemotherapy.

1975 • 85 citations

Allelic loss on chromosome 17 in human ovarian cancer

1993 • 84 citations

Early loss of heterozygosity on 17q in ovarian cancer. The Abe Ovarian Cancer Genetics Group.

1992 • 84 citations

Radiotherapeutic management of ovarian cancer.

1984 • 83 citations

Very frequent loss of heterozygosity throughout chromosome 17 in sporadic ovarian carcinoma

1993 • 83 citations

A common region of deletion on chromosome 17q in both sporadic and familial epithelial ovarian tumors distal to BRCA1.

1994 • 82 citations

Increased serum levels of macrophage colony-stimulating factor in ovarian cancer

1991 • 79 citations

Peritoneoscopy in the staging and follow-up of ovarian cancer.

1975 • 79 citations

Doppler ultrasound assessment of tumor vascularity in gynecologic disorders.

1989 • 76 citations

Randomized study of whole-abdomen irradiation versus pelvic irradiation plus cyclophosphamide in treatment of early ovarian cancer

1990 • 75 citations

Sonography of ovarian tumors: predictability of tumor type

1983 • 75 citations

National survey of ovarian carcinoma. I. A patient care evaluation study of the American College of Surgeons.

1993 • 74 citations

Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors

1994 • 71 citations

Surgical staging of carcinoma of the ovaries.

1989 • 64 citations

Watch and wait after careful surgical treatment and staging in well-differentiated early ovarian cancer

1991 • 62 citations

High-Risk Early-Stage Ovarian Cancer Randomized Clinical Trial Comparing Cisplatin Plus Cyclophosphamide versus Whole Abdominal Radiotherapy

1994 • 62 citations

Allele Loss at the Retinoblastoma Locus in Human Ovarian Cancer

1991 • 61 citations

A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1

1994 • 61 citations

Limited epithelial carcinoma of the ovary treated with curative intent by the intraperitoneal installation of radiocolloids

1978 • 59 citations

Increased serum levels of macrophage colony-stimulating factor in ovarian cancer

1991 • 57 citations

Tubal ligation, hysterectomy, and risk of ovarian cancer. A prospective study

1993 • 55 citations

Activation of c-erbB-2 and prognosis in ovarian carcinoma. Comparison with histologic type, grade, and stage

1994 • 55 citations

Cancer Risk and Incidence Trends: The Connecticut Perspective

1988 • 51 citations

"The Estimated Effect of Oral Contraceptive Use on the Cumulative Risk of Epithelial Ovarian Cancer."

1994 • 50 citations

OVX1 radioimmunoassay complements CA-125 for predicting the presence of residual ovarian carcinoma at second-look surgical surveillance procedures.

1993 • 49 citations

Surgical Staging of Carcinoma of the Ovaries

1990 • 47 citations

Analysis of postoperative radiation therapy in stage I through III epithelial ovarian carcinoma.

1987 • 44 citations

Five-year survival for stage IC or stage I grade 3 epithelial ovarian cancer treated with cisplatin-based chemotherapy

1992 • 41 citations

Blood flow characteristics of ovarian tumors: Implications for ovarian cancer screening

1995 • 41 citations

Treatment of ovarian cancer: current status.

1994 • 39 citations

Comparison of endovaginal ultrasound and cytological evaluation of cystic ovarian tumors.

1991 • 39 citations

Strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens CA 125, CA 15-3, and TAG 72.3.

1992 • 37 citations

Postoperative abdominopelvic radiation therapy for ovarian cancer

1988 • 37 citations

Prognostic Significance of DNA Content in Epithelial Ovarian Cancer

1994 • 33 citations

Platinum‐based chemotherapy of high‐risk stage I epithelial ovarian cancer following comprehensive surgical staging

1994 • 33 citations

Preoperative sonography of malignant ovarian neoplasms

1981 • 32 citations

Whole chromosome 17 loss in ovarian cancer

1993 • 31 citations

Epithelial ovarian cancer and combination oral contraceptives

1982 • 31 citations

DIAGNOSTIC VALUE OF PERITONEAL WASHINGS

1958 • 30 citations

Ultrasound‐guided puncture of cystic tumors in the lower pelvis of young women

1989 • 30 citations

Pathology of Early Malignant Change in the Ovary

1993 • 29 citations

Intraperitoneal radioactive phosphorus therapy in ovarian carcinoma. Analysis of 313 patients treated primarily or at second-look laparotomy

1993 • 28 citations

Does rupture of cystic carcinoma during operation influence the prognosis?

1968 • 27 citations

Intraperitoneal radioactive phosphorus therapy in ovarian carcinoma. Analysis of 313 patients treated primarily or at second‐look laparotomy

1993 • 26 citations

Ovarian cancer screening

1993 • 26 citations

EARLY STAGE OVARIAN CANCER

1985 • 24 citations

Strategies for improving the specificity of screening for ovarian cancer with tumor-associated antigens CA 125, CA 15-3, and TAG 72.3

1993 • 22 citations

Determinants of survival of patients with epithelial ovarian carcinoma following whole abdomen irradiation (WAR)

1988 • 20 citations

Adjuvant cisplatin-based chemotherapy for stage I ovarian adenocarcinoma: A preliminary report

1989 • 19 citations

Amplification of HER-2/neu oncogene in human ovarian cancer

1992 • 19 citations

Cisplatin-based chemotherapy for stage II ovarian adenocarcinoma: A preliminary report

1990 • 14 citations

A phase II trial of adjuvant cisplatin and doxorubicin in Stage I epithelial ovarian cancer

1991 • 14 citations

External beam radiotherapy in the management of ovarian carcinoma

1993 • 12 citations

The expression of c-erbB-2 (HER-2/neu) oncogene in invasive ovarian malignancies

1994 • 12 citations

Chemotherapy Consisting of Cisplatin, Doxorubicin, and Cyclophosphamide as an Adjunct to Surgery in Stage Ic-II Epithelial Ovarian Carcinoma

1989 • 11 citations

Screening, Imaging, and Early Diagnosis of Ovarian Cancer

1994 • 11 citations

Adjuvant cisplatin-based chemotherapy for stage I and II ovarian cancer: a 7-year experience

1991 • 8 citations

Localized ovarian cancer in the elderly: The gynecologic oncology group experience

2010 • 7 citations

Adjuvant treatment of early stage ovarian carcinoma.

1990 • 2 citations