A Comprehensive Human Linkage Map with Centimorgan Density

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Hypervariable ‘minisatellite’ regions in human DNA

1985 • 3,789 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

1989 • 3,458 citations

Strategies for multilocus linkage analysis in humans.

1984 • 2,600 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

1994 • 1,884 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

A second-generation linkage map of the human genome

1992 • 1,721 citations

Variable Number of Tandem Repeat (VNTR) Markers for Human Gene Mapping

1987 • 1,683 citations

A General Model for the Genetic Analysis of Pedigree Data

1971 • 1,595 citations

Sequential tests for the detection of linkage.

1955 • 1,590 citations

Construction of multilocus genetic linkage maps in humans.

1987 • 1,461 citations

The investigation of linkage between a quantitative trait and a marker locus

1972 • 1,398 citations

High-Resolution Mapping of Human Chromosome 11 by in Situ Hybridization with Cosmid Clones

1990 • 1,357 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

1974 • 1,022 citations

Number of CpG islands and genes in human and mouse.

1993 • 986 citations

A genetic linkage map of the human genome

1987 • 913 citations

A Common Language for Physical Mapping of the Human Genome

1989 • 876 citations

Digenic Retinitis Pigmentosa Due to Mutations at the Unlinked Peripherin/ RDS and ROM1 Loci

1994 • 740 citations

Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach.

1991 • 665 citations

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

1988 • 636 citations

Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis

1985 • 606 citations

Centre d'Etude du polymorphisme humain (CEPH): Collaborative genetic mapping of the human genome

1990 • 595 citations

Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland

1992 • 571 citations

A genetic map of the mouse with 4,006 simple sequence length polymorphisms

1994 • 543 citations

Positional cloning: Let's not call it reverse anymore

1992 • 485 citations

A first-generation physical map of the human genome

1993 • 446 citations

Multiplex PCR amplification from the CFTR gene using DNA prepared from buccal brushes/swabs

1993 • 416 citations

Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map

1994 • 405 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segment

1985 • 390 citations

Cryptic and polar variation of the fragile X repeat could result in predisposing normal alleles

1994 • 357 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 355 citations

A New Five-Year Plan for the U.S. Human Genome Project

1993 • 317 citations

An estimate of unique DNA sequence heterozygosity in the human genome

1985 • 297 citations

Direct selection: a method for the isolation of cDNAs encoded by large genomic regions.

1991 • 271 citations

Origin of the expansion mutation in myotonic dystrophy

1993 • 213 citations

Integrated human genome–wide maps constructed using the CEPH reference panel

1994 • 185 citations

Exon trapping: a genetic screen to identify candidate transcribed sequences in cloned mammalian genomic DNA.

1990 • 178 citations

Comparative Analysis of Human DNA Variations by Fluorescence-Based Sequencing of PCR Products

1994 • 167 citations

Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci.

1985 • 160 citations

Influence of aberrant observations on high-resolution linkage analysis outcomes.

1991 • 153 citations

The CEPH Consortium Linkage Map of Human Chromosome 13

1993 • 148 citations

Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.

1994 • 129 citations

Limits of resolution of genetic linkage studies: implications for the positional cloning of human disease genes.

1994 • 121 citations

Molecular basis of splotch and Waardenburg Pax-3 mutations.

1994 • 114 citations

The CEPH consortium linkage map of human chromosome 1

1991 • 96 citations

The linkage between the genes for colour-blindness and haemophilia in man

1937 • 87 citations

Use of variable simple sequence motifs as genetic markers: application to study of myotonic dystrophy

1989 • 83 citations

Linkage disequilibrium and evolutionary relationships of DNA variants (restriction enzyme fragment length polymorphisms) at the serum albumin locus.

1984 • 79 citations

Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.

1989 • 77 citations

The CEPH consortium primary linkage map of human chromosome 10

1990 • 69 citations

Oligonucleotide probes for the analysis of specific repetitive DNA sequences by fluorescence in situ hybridization

1992 • 61 citations

CEPH(ヒト多形性研究センター)共同製作ヒト1番染色体連鎖地図

1991 • 58 citations

New alleles at microsatellite loci in CEPH families mainly arise from somatic mutations in the lymphoblastoid cell lines

1994 • 48 citations

DNA elution and amplification by polymerase chain reaction from dried blood spots.

1992 • 42 citations

Linkage disequilibrium between two highly polymorphic microsatellites.

1991 • 37 citations

Retreat of the triplet repeat?

1993 • 29 citations

CEPH Consortium Map of Chromosome 9

1994 • 27 citations

The CEPH consortium linkage map of human chromosome 2

1992 • 8 citations

The CEPH consortium linkage map of human chromosome 15q

1992 • 5 citations

Deleted Work

1955 • 0 citations