Internalization of the granulocyte-macrophage colony-stimulating factor receptor is not required for induction of protein tyrosine phosphorylation in human myeloid cells

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Selective growth response to IL‐3 of a human leukaemic cell line with megakaryoblastic features

1988 • 314 citations

Hierarchical down-modulation of hemopoietic growth factor receptors

1985 • 314 citations

Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins

1990 • 294 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines.

1988 • 222 citations

The granulocyte—Macrophage colony stimulating factors

1985 • 215 citations

Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine.

1984 • 209 citations

Leukotriene production in human neutrophils primed by recombinant human granulocyte/macrophage colony-stimulating factor and stimulated with the complement component C5A and FMLP as second signals.

1988 • 185 citations

Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf.

1990 • 179 citations

Heterogeneity in Human Interleukin-3 Receptors

1989 • 153 citations

Tyrosine phosphorylation in human neutrophil

1989 • 140 citations

Regulation of the production and function of granulocytes and monocytes.

1988 • 136 citations

Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product.

1990 • 128 citations

Multiple Hematopoietic Growth Factors Signal Through Tyrosine Phosphorylation

1990 • 125 citations

Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line.

1988 • 120 citations

Diabetes-induced functional and structural changes in insulin receptors from rat skeletal muscle.

1986 • 116 citations

Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNA.

1990 • 112 citations

Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1.

1988 • 110 citations

Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line

1991 • 105 citations

Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein.

1988 • 104 citations

Granulocyte-macrophage colony-stimulating factor and human neutrophils: role of guanine nucleotide regulatory proteins.

1989 • 102 citations

Regulation of surface expression of the granulocyte/macrophage colony-stimulating factor receptor in normal human myeloid cells.

1990 • 99 citations

The v-fms oncogene induces factor-independent growth and transformation of the interleukin-3-dependent myeloid cell line FDC-P1.

1987 • 91 citations

Specific Binding, Internalization, and Degradation of Human Neutrophil Activating Factor by Human Polymorphonuclear Leukocytes

1989 • 76 citations

Differentiation-associated expression of two functionally distinct classes of granulocyte-macrophage colony-stimulating factor receptors by human myeloid cells.

1990 • 75 citations

Interleukin-3 stimulates the tyrosine phosphorylation of the 140-kilodalton interleukin-3 receptor

1989 • 74 citations

Binding of G-CSF, GM-CSF, tumor necrosis factor-alpha, and gamma- interferon to cell surface receptors on human myeloid leukemia cells triggers rapid tyrosine and serine phosphorylation of a 75-Kd protein

1990 • 69 citations

Phorbol 12-myristate 13-acetate inhibits granulocyte-macrophage colony stimulating factor-induced protein tyrosine phosphorylation in a human factor-dependent hematopoietic cell line.

1991 • 67 citations

The insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes.

1986 • 65 citations

Expression of Transfected Recombinant Oncogenes Increases Radiation Resistance of Clonal Hematopoietic and Fibroblast Cell Lines Selectively at Clinical Low Dose Rate

1990 • 61 citations

The fms oncogene

1988 • 58 citations

Specific binding, internalization, and degradation of human recombinant interleukin‐3 by cells of the acute myelogenous, leukemia line, KG‐1

1988 • 58 citations

Phorbol esters potentiate tyrosine phosphorylation of epidermal growth factor receptors in A431 membranes by a calcium-independent mechanism.

1984 • 55 citations

Mouse NIH 3T3 cells expressing human colony-stimulating factor 1 (CSF-1) receptors overgrow in serum-free medium containing human CSF-1 as their only growth factor.

1989 • 55 citations

Transfer of functional EGF receptors to an IL3‐dependent cell line

1988 • 53 citations

Internalisation and recycling of the granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) receptor on a murine myelomonocytic leukemia

1987 • 51 citations

Inhibition of colony-stimulating factor-1 activity by monoclonal antibodies to the human CSF-1 receptor

1989 • 50 citations

Abrogation of factor-dependence in two IL-3-dependent cell lines can occur by two distinct mechanisms.

1989 • 48 citations

Effect of infection with murine recombinant retroviruses containing the v-src oncogene on interleukin 2- and interleukin 3-dependent growth states.

1987 • 47 citations

Identification of functionally distinct domains of human granulocyte- macrophage colony-stimulating factor using monoclonal antibodies

1991 • 43 citations

Binding, Internalization, and Degradation of¹²⁵I-Multipotential Colony-Stimulating Factor (Interleukin-3) By FDCP-1 Cells

1988 • 40 citations

Down-modulation of high-affinity receptors for erythropoietin on murine erythroblasts by interleukin 3.

1988 • 36 citations

Lymphocyte activation and capping of hormone receptors

1988 • 30 citations

Effects of recombinant human granulocyte-macrophage colony-stimulating factor on intracellular pH in mature granulocytes

1988 • 23 citations

Isoquinolinesulfonamide protein kinase inhibitors H7 and H8 enhance the effects of granulocyte-macrophage colony-stimulating factor (GM-CSE) on neutrophil function and inhibit GM-CSF receptor internalization

1990 • 19 citations

Binding, internalization and degradation of radio-iodinated interleukin 3 and granulocyte-macrophage colony stimulating factor by various hemopoietic cells

1990 • 6 citations

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