Diabetes-induced functional and structural changes in insulin receptors from rat skeletal muscle.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.

1982 • 441 citations

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

1979 • 422 citations

Insulin Resistance is a Prominent Feature of Insulin-dependent Diabetes

1982 • 365 citations

Characterization of Rous sarcoma virus src gene products synthesized in vitro

1978 • 352 citations

Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

1983 • 324 citations

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

1984 • 299 citations

Studies of Tissue Permeability

1959 • 280 citations

Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors

1981 • 267 citations

Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation.

1982 • 254 citations

Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats.

1984 • 237 citations

Receptor-mediated phosphorylation of the hepatic insulin receptor: Evidence that the M _r 95,000 receptor subunit is its own kinase

1983 • 213 citations

Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells.

1984 • 208 citations

Role of glycosylation in the processing of newly translated insulin proreceptor in 3T3-L1 adipocytes.

1984 • 207 citations

Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice

1985 • 200 citations

Insulin-sensitive and insulin-insensitive types of diabetes mellitus.

1939 • 188 citations

Regulation of Glucose Uptake in Muscle

1961 • 183 citations

A possible mechanism of insulin resistance in the rat adipose cell in streptozotocin-induced diabetes mellitus. Depletion of intracellular glucose transport systems.

1981 • 176 citations

Defect in Phosphorylation of Insulin Receptors in Cells from an Insulin-Resistant Patient with Normal Insulin Binding

1984 • 167 citations

Effects of Streptozotocin-induced Diabetes on Insulin Binding, Glucose Transport, and Intracellular Glucose Metabolism in Isolated Rat Adipocytes

1979 • 165 citations

Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity.

1981 • 160 citations

GLUCOSE, INSULIN AND SOMATOSTATIN INFUSION FOR THE DETERMINATION OF INSULIN SENSITIVITY

1977 • 154 citations

Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance.

1984 • 146 citations

Effect of Fasting and Streptozotocin Diabetes on Insulin Binding and Action in the Isolated Mouse Soleus Muscle

1979 • 109 citations

Insulin stimulated phosphorylation of its own receptor. Activation of a tyrosine-specific protein kinase that is tightly associated with the receptor.

1983 • 107 citations

Development of insulin resistance in normal dogs following alloxan-induced insulin deficiency

1977 • 89 citations

Effect of Fasting and Streptozotocin in the Obese-hyperglycemic (ob/ob) Mouse: Apparent Lack of a Direct Relationship Between Insulin Binding and Insulin Effects

1977 • 67 citations

Insulin binding and glucose metabolism in adipocytes of streptozotocin-diabetic rats.

1978 • 67 citations

Extreme Insulin Resistance in Association with Abnormally High Binding Affinity of Insulin Receptors from a Patient with Leprechaunism: Evidence for a Defect Intrinsic to the Receptor

1982 • 56 citations

Characterization of insulin receptor carbohydrate by comparison of chemical and enzymatic deglycosylation

1985 • 52 citations

Biosynthesis of the epidermal growth factor receptor in human epidermoid carcinoma-derived A431 cells.

1984 • 51 citations

Phosphorylation of Insulin Receptors Solubilized from Rat Skeletal Muscle

1984 • 47 citations

Separation of nucleotides by ion-pair, reversed-phase high-performance liquid chromatography

1983 • 38 citations

Normal hepatic insulin receptor autophosphorylation in nonketotic diabetes mellitus

1985 • 36 citations

Treatment of Juvenile-onset Diabetes by Subcutaneous Infusion of Insulin with a Portable Pump

1980 • 27 citations

Restoration of Glucose Homeostasis in Insulin-dependent Diabetic Subjects: An Inducible Process

1982 • 26 citations

Biogenesis, transit, and functional properties of the insulin proreceptor and modified insulin receptors in 3T3-L1 adipocytes

1984 • 24 citations

Studies of the Metabolism of Isolated Livers of Normal and Alloxan-diabetic Rats Perfused with Insulin

1968 • 22 citations

INSULIN SENSITIVITY AND ¹³¹I INSULIN METABOLISM IN JUVENILE‐TYPE DIABETICS

1967 • 21 citations

Removal of sialic acids from the purified insulin receptor results in enhanced insulin-binding and kinase activities

1985 • 19 citations

Insulin Binding and Response in Erythroblastic Leukemic Cells

1980 • 15 citations

Restoration of glucose homeostasis in insulin-dependent diabetic subjects. An inducible process

1982 • 12 citations

The Effects of Streptozotocin Diabetes on the Activities of Rat Liver GlycosyItransferases

1983 • 10 citations

Insulin binding and response in erythroblastic leukemic cells

1980 • 8 citations

Predicting Insulin Requirements for a Portable Insulin Pump Using the Biostator: Evidence for Reversible Insulin Resistance in Poorly Controlled Type I Diabetics

1983 • 7 citations

Molecular Weight Determination and Physical Properties

1977 • 6 citations

Increased affinity of insulin receptor on hepatocytes from streptozotocin-induced diabetic rats.

1984 • 5 citations

The effects of streptozotocin diabetes on the activities of rat liver glycosyltransferases

1983 • 4 citations