The Evolving Role of Bone Marrow Transplantation in the Treatment of Chronic Myelogenous Leukemia

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

CLINICAL MANIFESTATIONS OF GRAFT-VERSUS-HOST DISEASE IN HUMAN RECIPIENTS OF MARROW FROM HL-A-MATCHED SIBLING DONOR,S

1974 • 3,686 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Bone-Marrow Transplantation

1975 • 1,667 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

1986 • 1,453 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

Prognostic discrimination in "good-risk" chronic granulocytic leukemia

1984 • 919 citations

Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage

1977 • 888 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

1983 • 848 citations

Marrow Transplantation from Related Donors Other Than HLA-Identical Siblings

1985 • 844 citations

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

1988 • 741 citations

Marrow Transplantation for the Treatment of Chronic Myelogenous Leukemia

1986 • 566 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

Detection of Minimal Residual Cells Carrying the t(14;18) by DNA Sequence Amplification

1987 • 426 citations

Bone Marrow Transplantation for Patients with Chronic Myeloid Leukemia

1986 • 422 citations

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

1987 • 405 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR CHRONIC MYELOGENOUS LEUKAEMIA

1984 • 265 citations

Evidence of a New Chimericbcr/c-ablmRNA in Patients with Chronic Myelocytic Leukemia and the Philadelphia Chromosome

1985 • 253 citations

Expression of a Distinctive BCR-ABL Oncogene in Ph ¹ -Positive Acute Lymphocytic Leukemia (ALL)

1988 • 252 citations

Graft-versus-Host-Reactions: A Review

1976 • 227 citations

Staging and prognosis in chronic myelogenous leukemia.

1988 • 221 citations

A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia

1987 • 201 citations

Results of treatment of Ph'+ chronic myelogenous leukemia with an intensive treatment regimen (L-5 protocol)

1979 • 194 citations

Ph1-Positive Leukaemia, Including Chronic Myelogenous Leukaemia

1980 • 191 citations

CHRONIC MYELOGENOUS LEUKEMIA

1924 • 185 citations

The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity

1985 • 184 citations

Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia

1989 • 183 citations

The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia.

1987 • 179 citations

Disappearance of pH¹-Positive Cells in Four Patients with Chronic Granulocytic Leukemia after Chemotherapy, Irradiation and Marrow Transplantation from an Identical Twin

1979 • 161 citations

Growth characteristics of leukemic and normal hematopoietic cells in Ph' + chronic myelogenous leukemia and effects of intensive treatment

1982 • 159 citations

Graft-versus-leukaemia reactivity induced by alloimmunisation without augmentation of graft-versus-host reactivity

1979 • 157 citations

POLYMERASE CHAIN REACTION FOR DETECTION OF RESIDUAL LEUKAEMIA

1989 • 152 citations

Indications for marrow transplantation in chronic myelogenous leukemia [see comments]

1989 • 151 citations

Graft-versus-leukemia following bone marrow transplantation.

1987 • 149 citations

Characterization of natural killer cells with antileukemia activity following allogeneic bone marrow transplantation

1986 • 148 citations

Characteristics of the Terminal Phase of Chronic Granulocytic Leukemia

1968 • 144 citations

C-abl and bcr are rearranged in a Ph1-negative CML patient.

1985 • 144 citations

Treatment of Chronic Granulocytic Leukemia with Chemoradiotherapy and Transplantation of Marrow from Identical Twins

1982 • 137 citations

The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript.

1986 • 128 citations

Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation

1985 • 118 citations

Detection of two alternative bcr/abl mRNA junctions and minimal residual disease in Philadelphia chromosome positive chronic myelogenous leukemia by polymerase chain reaction

1989 • 117 citations

Graft‐versus‐Host Disease

1985 • 117 citations

Cytogenetic Studies in Acute Myelocytic Leukemia with Special Emphasis on the Occurrence of Ph1 Chromosome

1970 • 110 citations

Cytogenetic events after bone marrow transplantation for chronic myeloid leukemia in chronic phase

1988 • 107 citations

Bone marrow transplantation: Current controversies

1988 • 104 citations

CML patients in blast crisis have breakpoints localized to a specific region of the BCR

1987 • 100 citations

The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients [see comments]

1988 • 96 citations

CHROMOSOME ABNORMALITIES IN HUMAN LEUKEMIA

1980 • 85 citations

T cell depletion in bone marrow transplantation.

1988 • 85 citations

Evidence that the phl gene encodes a 160,000-dalton phosphoprotein with associated kinase activity.

1987 • 84 citations

Detection of the molecular abnormality in chronic myeloid leukemia by use of the polymerase chain reaction

1988 • 84 citations

The early complications of bone marrow transplantation.

1984 • 80 citations

HLA-identical marrow transplantation during accelerated-phase chronic myelogenous leukemia: analysis of survival and remission duration

1988 • 78 citations

Rearrangement in the Breakpoint Cluster Region and the Clinical Course in Philadelphia-Negative Chronic Myelogenous Leukemia

1986 • 77 citations

Unrelated donor bone marrow transplantation therapy for chronic myelogenous leukemia

1987 • 64 citations

T cells and probably B cells arise from the malignant clone in chronic myelogenous leukemia.

1985 • 59 citations

Detection by enzymatic amplification of bcr-abl mRNA in peripheral blood and bone marrow cells of patients with chronic myelogenous leukemia

1989 • 48 citations

The emerging genetics of acute lymphoblastic leukemia: clinical and biologic implications.

1985 • 31 citations

Chronic myelogenous leukemia: is aggressive treatment indicated?

1985 • 29 citations

Relapse after allogeneic bone marrow transplantation for Philadelphia chromosome positive chronic myeloid leukemia: cytogenetic analysis of 24 patients.

1988 • 28 citations

Philadelphia‐positive metaphases in the marrow after bone marrow transplantation for chronic granulocytic leukemia

1986 • 28 citations

Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation—Results of a European cooperative study

1987 • 27 citations

Allogeneic and syngeneic marrow transplantation following high dose dimethylbusulfan, cyclophosphamide and total body irradiation.

1987 • 24 citations

Complete remission after autografting for chronic myeloid leukaemia

1987 • 24 citations

Response of chronic myelogenous leukemia patients to COAP—splenectomy. A southwest oncology group study

1984 • 22 citations

Autografting in chronic granulocytic leukaemia

1986 • 13 citations

Autologous marrow transplantation for patients with chronic myelogenous leukemia (CML) in blast crisis

1984 • 13 citations

Monoclonal antibodies: their use in bone marrow transplantation.

1987 • 11 citations

BONE-MARROW TRANSPLANTATION (BMT) FOR CHRONIC MYELOID-LEUKEMIA (CML) USING MATCHED UNRELATED DONORS

1988 • 2 citations