Serial depletion and regeneration of the murine hematopoietic system. Implications for hematopoietic organization and the study of cellular aging

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

The relationship between the spleen colony-forming cell and the haemopoietic stem cell.

1978 • 2,290 citations

Mutation selection and the natural history of cancer

2006 • 1,185 citations

A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS

1964 • 889 citations

Stem Cell Concepts

1979 • 569 citations

The Effect of Differing Demands for Blood Cell Production on DNA Synthesis by Hemopoietic Colony-Forming Cells of Mice

1965 • 515 citations

Ageing of Clones of Mammalian Cells

1973 • 409 citations

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

1964 • 339 citations

The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study.

1968 • 276 citations

Decline in colony‐forming ability of marrow cells subjected to serial transplantation into irradiated mice

1964 • 276 citations

Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging.

1978 • 224 citations

HOW MANY CELL-GENERATIONS ?

1965 • 206 citations

Hydroxyurea. I. Acute cell death in proliferating tissues in rats.

1967 • 160 citations

Limited potential of circulating haemopoietic stem cells

1975 • 158 citations

Proliferative capacity of murine hematopoietic stem cells.

1978 • 156 citations

Testing the Commitment Theory of Cellular Aging

1977 • 154 citations

THE FATE OF SERIALLY TRANSPLANTED BONE MARROW CELL POPULATIONS FROM YOUNG AND OLD DONORS

1976 • 145 citations

PHYSICAL SEPARATION OF HEMOPOIETIC STEM CELLS DIFFERING IN THEIR CAPACITY FOR SELF-RENEWAL

1969 • 135 citations

Review Lectures on Senescence - II. Heterochronic transplantation in the study of ageing

1962 • 127 citations

Lymphocyte Content and Proliferative Capacity of Serially Transplanted Mouse Bone Marrow

1964 • 110 citations

The self renewal probability of hemopoietic stem cells

1968 • 108 citations

Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice

1972 • 106 citations

The biology of human aging

1973 • 95 citations

Normal Function of Transplanted Marrow Cell Lines from Aged Mice

1975 • 90 citations

Mutation selection and the natural history of cancer

2006 • 88 citations

A COMPARATIVE STUDY OF THE REPOPULATING POTENTIAL OF GRAFTS FROM VARIOUS HAEMOPOIETIC SOURCES: CFU REPOPULATION

1970 • 68 citations

RECOVERY OF PROLIFERATING HAEMOPOIETIC PROGENITOR CELLS AFTER KILLING BY HYDROXYUREA

1975 • 57 citations

Regulation of stem cell renewal and differentiation: possible significance in aging.

1971 • 51 citations

Some Properties of the Circulating Hemopoietic Stem Cells

1974 • 42 citations

The Pluripotent Stem Cell

1979 • 40 citations

COMPARTMENTS AND CELL FLOWS WITHIN THE MOUSE HAEMOPOIETIC SYSTEM

1975 • 31 citations

Effect of Repeated Doses of X-Rays or 14 MeV Neutrons on Mouse Bone Marrow

1974 • 29 citations

Proliferation Regulators in Haemopoiesis

1979 • 22 citations

Congenital and Induced Defects in Haemopoietic Environments, Stem Cell Proliferation and Differentiation

1979 • 12 citations

[Serial grafts of homologous bone marrow in irradiated mice].

1959 • 8 citations

Heterogeneity and ageing of haematopoietic stem cells.

1978 • 5 citations