The deletion in both common types of hereditary persistence of fetal hemoglobin is approximately 105 kilobases

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

Separation of Large DNA Molecules by Contour-Clamped Homogeneous Electric Fields

1986 • 1,525 citations

The structure of histone-depleted metaphase chromosomes

1977 • 1,083 citations

Hemoglobin: Molecular, Genetic and Clinical Aspects.

1986 • 1,005 citations

On the mechanism of DNA replication in mammalian chromosomes

1968 • 950 citations

Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field

1986 • 920 citations

Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis

1984 • 887 citations

A fixed site of DNA replication in eucaryotic cells

1980 • 669 citations

Eucaryotic DNA: Organization of the genome for replication

1978 • 476 citations

Thalassemia Syndromes

2009 • 476 citations

The Molecular Genetics of Human Hemoglobin

1984 • 420 citations

DNA sequence variation associated with elevated fetal G gamma globin production

1985 • 384 citations

Recombination at the human α-globin gene cluster: Sequence features and topological constraints

1987 • 345 citations

Characterisation of deletions which affect the expression of fetal globin genes in man

1979 • 269 citations

Unexpected relationships between four large deletions in the human β-globin gene cluster

1983 • 218 citations

G to A substitution in the distal CCAAT box of the Aγ-globin gene in Greek hereditary persistence of fetal haemoglobin

1985 • 198 citations

Construction of a General Human Chromosome Jumping Library, with Application to Cystic Fibrosis

1987 • 195 citations

DEVELOPMENTAL REGULATION OF HUMAN GLOBIN GENES

1985 • 190 citations

A point mutation in the Aγ-globin gene promoter in Greek hereditary persistence of fetal haemoglobin

1985 • 189 citations

γ-β-Thalassaemia studies showing that deletion of the γ- and δ-genes influences β-globin gene expression in man

1980 • 184 citations

Molecular analysis of the Duchenne muscular dystrophy region using pulsed field gel electrophoresis

1987 • 171 citations

Physical mapping of the globin gene deletion in hereditary persistence of foetal haemoglobin (HPFH)

1980 • 157 citations

A physical map of 4 million bp around the Duchenne muscular dystrophy gene on the human X-chromosome

1986 • 152 citations

A gene deletion ending within a complex array of repeated sequences 3' to the human beta-globin gene cluster.

1986 • 149 citations

G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene.

1984 • 140 citations

Analysis of Genome Organization and Rearrangements by Pulsed Field Gradient Gel Electrophoresis

1986 • 136 citations

Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene expression in man.

1983 • 129 citations

Megabase-Scale Mapping of the HLA Gene Complex by Pulsed Field Gel Electrophoresis

1987 • 126 citations

Long-range restriction map around the Duchenne muscular dystrophy gene

1986 • 120 citations

Molecular Analysis of the High-Hemoglobin-F Phenotype in Saudi Arabian Sickle Cell Anemia

1987 • 118 citations

[35] Strategies for mapping and cloning macroregions of mammalian genomes

1987 • 112 citations

Heterogeneity in the molecular basis of hereditary persistence of fetal haemoglobin

1980 • 97 citations

γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster

1986 • 95 citations

A Chinese^Gγ⁺(^Aγδβ)⁰thalassemia deletion: comparison to other deletions in the human β-globin gene cluster and sequence analysis of the breakpoints

1985 • 89 citations

A giant locus for the Duchenne and Becker muscular dystrophy gene

1987 • 88 citations

Chinese A gamma fetal hemoglobin: C to T substitution at position-196 of the A gamma gene promoter

1986 • 66 citations

Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human epsilon-globin gene.

1985 • 61 citations

Nonrandom distribution of repeated DNA sequences with respect to supercoiled loops and the nuclear matrix.

1982 • 60 citations

Heterogeneity of DNA deletion in gamma delta beta-thalassemia.

1981 • 47 citations