Molecular Analysis of the High-Hemoglobin-F Phenotype in Saudi Arabian Sickle Cell Anemia

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa.

1984 • 415 citations

Nonrandom association of polymorphic restriction sites in the β-globin gene cluster

1982 • 408 citations

DNA sequence variation associated with elevated fetal G gamma globin production

1985 • 384 citations

A history of the human fetal globin gene duplication

1981 • 349 citations

Hematologically and Genetically Distinct Forms of Sickle Cell Anemia in Africa

1985 • 268 citations

Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients.

1985 • 238 citations

BENIGN SICKLE-CELL ANÆMIA

1972 • 225 citations

Origin of the beta S-globin gene in blacks: the contribution of recurrent mutation or gene conversion or both.

1984 • 221 citations

G to A substitution in the distal CCAAT box of the Aγ-globin gene in Greek hereditary persistence of fetal haemoglobin

1985 • 198 citations

A point mutation in the Aγ-globin gene promoter in Greek hereditary persistence of fetal haemoglobin

1985 • 189 citations

Reselution of hemoglobin subunits by electrophoresis in acid urea polyacrylamide gels containing Triton X-100

1978 • 156 citations

G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene.

1984 • 140 citations

The -158 site 5' to the G gamma gene and G gamma expression

1985 • 137 citations

Fetal Haemoglobin Production and the Sickle Gene in the Oases of Eastern Saudi Arabia

1978 • 129 citations

A molecular study of a family with Greek hereditary persistence of fetal hemoglobin and beta-thalassemia.

1984 • 102 citations

Erythroid Progenitors Circulating in the Blood of Adult Individuals Produce Fetal Hemoglobin in Culture

1978 • 82 citations

High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined

1986 • 80 citations

Fetal Haemoglobin in Homozygous Sickle Cell Disease

1975 • 77 citations

A gene controlling fetal hemoglobin expression in adults is not linked to the non-alpha globin cluster.

1983 • 75 citations

Two independent genetic factors in the beta-globin gene cluster are associated with high G gamma-levels in the HbF of SS patients

1984 • 73 citations

High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined

1986 • 70 citations

Linkage Analysis of Nondeletion Hereditary Persistence of Fetal Hemoglobin

1982 • 65 citations

A genetic marker for elevated levels of haemoglobin F in homozygous sickle cell disease?

1985 • 62 citations

Hb F Synthesis in Sickle Cell Anaemia: a Comparison of Saudi Arab Cases with those of African Origin

1980 • 62 citations

On the Levels of Hemoglobins F and A2 in Sickle-cell Anemia and Some Related Disorders

1974 • 52 citations

Production of F cells in sickle cell anemia: regulation by a genetic locus or loci separate from the beta-globin gene cluster

1984 • 46 citations

Hematological Observations on Arabian SS Patients with a Homozygosity or Heterozygosity for a β^SChromosome with Haplotype #31

1985 • 39 citations

Quantal and proliferative cell cycles: how lineages generate cell diversity and maintain fidelity.

1983 • 34 citations

Increased HbF in sickle cell anemia is determined by a factor linked to the beta S gene from one parent

1984 • 34 citations

Hereditary persistence of fetal hemoglobin or (delta beta)o- thalassemia: three types observed in South-Chinese families

1985 • 34 citations

The Ratio of the ^Gγ and ^Aγ Chains: Variations due to Anomalies at the Molecular Level

1985 • 32 citations

Five adults with mild sickle cell anemia share a β^s chromosome with the same haplotype

1985 • 30 citations

Radio-ligand immunoassay for human hemoglobin variants

1981 • 21 citations