Characterisation of deletions which affect the expression of fetal globin genes in man

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.

1992 • 4,683 citations

Construction and characterization of new cloning vehicle. II. A multipurpose cloning system

1977 • 3,829 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Construction and characterization of new cloning vehicles I. Ampicillin-resistant derivatives of the plasmid pMB9

1977 • 1,055 citations

pBR322 restriction map derived from the DNA sequence: accurate DNA size markers up to 4361 nucleotide pairs long

1978 • 768 citations

A physical map of the DNA regions flanking the rabbit β-globin gene

1977 • 654 citations

The arrangement of simian virus 40 sequences in the DNA of transformed cells

1976 • 522 citations

Thalassemia Syndromes

2009 • 476 citations

Insertion of synthetic copies of human globin genes into bacterial plasmids

1978 • 350 citations

THE FUSION OF TWO PEPTIDE CHAINS IN HEMOGLOBIN LEPORE AND ITS INTERPRETATION AS A GENETIC DELETION

1962 • 331 citations

Analysis of the β-δ-globin gene loci in normal and hb lepore DNA: Direct determination of gene linkage and intergene distance

1978 • 260 citations

The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.

1978 • 242 citations

Patterns of puffing activity in the salivary gland chromosomes of Drosophila

1967 • 225 citations

Hereditary Persistence of Fetal Hemoglobin: A Study of 79 Affected Persons in 15 Negro Families in Baltimore

1963 • 215 citations

Patterns of puffing activity in the salivary gland chromosomes of Drosophila

1969 • 209 citations

Application of Endonuclease Mapping to the Analysis and Prenatal Diagnosis of Thalassemias Caused by Globin-Gene Deletion

1978 • 207 citations

THE PRESENT STATUS OF THE HETEROGENEITY OF FETAL HEMOGLOBIN IN β‐THALASSEMIA: AN ATTEMPT TO UNIFY SOME OBSERVATIONS IN THALASSEMIA AND RELATED CONDITIONS*

1974 • 167 citations

Hemoglobin Kenya, the product of fusion of γ and β polypeptide chains

1972 • 153 citations

Organization of human δ- and β-globin genes in cellular DNA and the presence of intragenic inserts

1978 • 141 citations

Structure of the human fetal globin gene locus

1979 • 113 citations

Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders

1978 • 104 citations

CONSTRUCTION AND CHARACTERIZATION OF CLONING VEHICLES

1976 • 99 citations

δβ-Thalassemia is due to a gene deletion

1976 • 97 citations

Absence of messenger RNA and gene DNA for β-globin chains in hereditary persistence of fetal hemoglobin

1976 • 86 citations

Abnormal or absent β mRNA in β0 Ferrara and gene deletion in δβ thalassaemia

1976 • 80 citations

Cloning Human Fetal γ Globin and Mouse α-Type Globin DNA: Characterization and Partial Sequencing

1978 • 76 citations

Deletion of the β-globin structure gene in hereditary persistence of foetal haemoglobin

1975 • 75 citations

Molecular Cloning of Recombinant DNA

1978 • 72 citations

A Homozygote for the Hb_Gγ Type of Foetal Haemoglobin in India: A Study of Two Indian and Four Negro Families

1972 • 46 citations

Organization of Immunoglobulin Genes

1978 • 37 citations

The ^Gγ‐δβ‐thalassemia and ^Gγ‐β°‐HPFH conditions in combination with β‐thalassemia and Hb S

1977 • 33 citations

α‐Thalassemia and β‐thalassemia in a turkish family

1977 • 30 citations

Further Studies of the Postnatal Change in Chemical Heterogeneity of Human Fetal Hemoglobin in Several Abnormal Conditions

1975 • 30 citations

Homozygotes for the hereditary persistence of fetal hemoglobin: The ratio of G? to A? chains and biosynthetic studies

1977 • 28 citations

Three Cases of Homozygous <i>β</i><i>δ</i>-Thalassaemia (or Microcythaemia) with High Haemoglobin F in a Sicilian Family

1968 • 27 citations

HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN¹

1969 • 21 citations