Antigen Responsive Antibody–Receptor Kinase Chimera

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.

1989 • 712 citations

Fluorescence ratio imaging of cyclic AMP in single cells

1991 • 686 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

Molecular components of the B-cell antigen receptor complex of the IgM class

1990 • 401 citations

Immunoglobulin gene expression in transformed lymphoid cells.

1983 • 400 citations

Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

1990 • 346 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

The B-cell antigen receptor of the five immunoglobulin classes

1991 • 302 citations

Recombinant antibodies possessing novel effector functions

1984 • 282 citations

Regulation of B Cell Antigen Receptor Signal Transduction and Phosphorylation by CD45

1991 • 269 citations

Specific Expression of a Tyrosine Kinase Gene, blk , in B Lymphoid Cells

1990 • 234 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin.

1990 • 225 citations

Activation of Bacterial Porin Gene Expression by a Chimeric Signal Transducer in Response to Aspartate

1989 • 207 citations

Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: construction of a heavy chain variable region-specific cDNA library.

1989 • 201 citations

Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.

1990 • 185 citations

Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells.

1985 • 171 citations

A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor

1986 • 160 citations

IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes.

1991 • 138 citations

Chimeric NGF-EGF Receptors Define Domains Responsible for Neuronal Differentiation

1991 • 116 citations

Construction and expression of a recombinant antibody-targeted plasminogen activator.

1987 • 94 citations

Co-capping of ras proteins with surface immunoglobulins in B lymphocytes

1990 • 81 citations

Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells.

1990 • 79 citations

A Chimeric, Ligand-Binding v- erb B/EGF Receptor Retains Transforming Potential

1987 • 78 citations

Single Chain Antibody (SCA) Encoding Genes: One-Step Construction and Expression in Eukaryotic Cells

1991 • 65 citations

Transmembrane signaling by a chimera of the Escherichia coli aspartate receptor and the human insulin receptor.

1989 • 56 citations

Microaggregation of hormone-occupied epidermal growth factor receptors on plasma membrane preparations.

1986 • 51 citations

Production of antibody-tagged enzymes by myeloma cells: Application to DNA polymerase I Klenow fragment

1986 • 43 citations

Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene.

1990 • 33 citations

Expression and characterization of an antibody binding specificity joined to insulin-like growth factor 1: potential applications for cellular targeting.

1990 • 33 citations

Haptenation of Viable Biological Carriers

1979 • 19 citations

Antibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptor.

1990 • 17 citations

neu protooncogene fused to an immunoglobulin heavy chain gene requires immunoglobulin light chain for cell surface expression and oncogenic transformation.

1988 • 15 citations