Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

1998 • 19,638 citations

U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease

1995 • 1,880 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Pharmacologic Therapy for Type 2 Diabetes Mellitus

1999 • 1,196 citations

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

2000 • 1,178 citations

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

1995 • 1,064 citations

Oral Antihyperglycemic Therapy for Type 2 Diabetes

2002 • 1,044 citations

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

1992 • 912 citations

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

1993 • 814 citations

Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects

1995 • 705 citations

Racial and ethnic differences in glycemic control of adults with type 2 diabetes.

1999 • 653 citations

Synthetic Exendin-4 (Exenatide) Significantly Reduces Postprandial and Fasting Plasma Glucose in Subjects with Type 2 Diabetes

2003 • 556 citations

Relationships of Upper Gastrointestinal Motor and Sensory Function With Glycemic Control

2001 • 456 citations

Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).

1999 • 439 citations

Kinetics of acetaminophen absorption and gastric emptying in man

1978 • 369 citations

Glucagon-Like Peptide-1 and Exendin-4 Stimulate β-Cell Neogenesis in Streptozotocin-Treated Newborn Rats Resulting in Persistently Improved Glucose Homeostasis at Adult Age

2001 • 367 citations

Effect on Glycemic Control of Exenatide (Synthetic Exendin-4) Additive to Existing Metformin and/or Sulfonylurea Treatment in Patients With Type 2 Diabetes

2003 • 358 citations

Exendin-4 Decelerates Food Intake, Weight Gain, and Fat Deposition in Zucker Rats

2000 • 295 citations

Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4

2002 • 288 citations

The Effect of Acute Hyperglycemia on Gastric Emptying in Man

1976 • 255 citations

Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro

2001 • 247 citations

The Insulinotropic Effect of Acute Exendin-4 Administered to Humans: Comparison of Nondiabetic State to Type 2 Diabetes

2002 • 244 citations

Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations

1999 • 192 citations

Type 2 Diabetes Mellitus: Update on Diagnosis, Pathophysiology, and Treatment

1999 • 187 citations

Tissue-specific Expression of Unique mRNAs That Encode Proglucagon-derived Peptides or Exendin 4 in the Lizard

1997 • 165 citations

Implications of the United Kingdom Prospective Diabetes Study

2002 • 164 citations

Pharmacokinetic actions of exendin‐4 in the rat: Comparison with glucagon‐like peptide‐1

2001 • 154 citations

Assessing Response Profiles from Incomplete Longitudinal Clinical Trial Data Under Regulatory Considerations

2003 • 131 citations

Pharmacology of exenatide (synthetic exendin-4) for the treatment of type 2 diabetes.

2003 • 85 citations

Accelerated gastric emptying of glucose in Zucker type 2 diabetic rats: role in postprandial hyperglycaemia

1997 • 35 citations

Diagnosis and Management of Diabetic Peripheral Neuropathy

1996 • 23 citations

Regulation of net hepatic glucose uptake: interaction of neural and pancreatic mechanisms

1996 • 17 citations