Thrombopoietin Does Not Induce Lineage-Restricted Commitment of Mpl-R Expressing Pluripotent Progenitors But Permits Their Complete Erythroid and Megakaryocytic Differentiation

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES

1964 • 3,400 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors

1986 • 901 citations

c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

1994 • 689 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

1996 • 589 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.

1996 • 445 citations

The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production.

1994 • 443 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 416 citations

Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro

1995 • 416 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Physical separation of hemopoietic stem cells from cells forming colonies in culture

1969 • 407 citations

The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit

1995 • 399 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets

1996 • 348 citations

Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.

1995 • 333 citations

Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors

1995 • 285 citations

The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors

1995 • 283 citations

Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice

1996 • 278 citations

Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.

1995 • 269 citations

Purification and Characterization of Thrombopoietin1

1995 • 251 citations

The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl

1995 • 235 citations

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

1995 • 218 citations

Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates

1995 • 204 citations

Murine thrombopoietin mRNA levels are modulated by platelet count

1995 • 200 citations

Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets

1996 • 189 citations

Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.

1995 • 183 citations

Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.

1993 • 174 citations

The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.

1995 • 170 citations

Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth.

1993 • 134 citations

Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin

1995 • 130 citations

Expression of retroviral vectors in transgenic mice obtained by embryo infection.

1987 • 128 citations

Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor

1995 • 124 citations

Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation

1996 • 111 citations

Cloning and Characterization of the Human Megakaryocyte Growth and Development Factor (MGDF) Gene

1995 • 110 citations

Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis

1996 • 107 citations

Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2

1995 • 97 citations

Cytokine production by primary bone marrow megakaryocytes

1994 • 87 citations

Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines.

1995 • 79 citations

Colony formation in agar by adult bone marrow multipotential hemopoietic cells

1980 • 67 citations

Murine pluripotent hematopoietic progenitors constitutively expressing a normal erythropoietin receptor proliferate in response to erythropoietin without preferential erythroid cell differentiation.

1994 • 46 citations

Lineage-restricted recruitment of immature hematopoietic progenitor cells in response to Epo after normal hematopoietic cell transfection with EpoR.

1995 • 40 citations

The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors

1995 • 27 citations