Second-Line Drug Therapy for Rheumatoid Arthritis

Cyclosporine

1989 • 1,340 citations

Efficacy of Low-Dose Methotrexate in Rheumatoid Arthritis

1985 • 861 citations

Methotrexate for Rheumatoid Arthritis

1994 • 612 citations

Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs.

1979 • 600 citations

EFFECTS OF HYDROXYCHLOROQUINE AND SULPHASALAZINE ON PROGRESSION OF JOINT DAMAGE IN RHEUMATOID ARTHRITIS

1989 • 568 citations

Dietary fish oil and olive oil supplementation in patients with Rheumatoid Arthritis clinical and immunologic effects

1990 • 544 citations

The Influence of HLA-DRB1 Genes on Disease Severity in Rheumatoid Arthritis

1992 • 520 citations

The comparative efficacy and toxicity of second‐line drugs in rheumatoid arthritis results of two metaanalyses

1990 • 471 citations

Biannual Radiographic Assessments of Hands and Feet in a Three‐Year Prospective Followup of Patients with Early Rheumatoid Arthritis

1992 • 441 citations

Reversible Lymphomas Associated with Epstein-Barr Virus Occurring during Methotrexate Therapy for Rheumatoid Arthritis and Dermatomyositis

1993 • 421 citations

Risk Factors for Cyclosporine-Induced Nephropathy in Patients with Autoimmune Diseases

1992 • 409 citations

Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment

1985 • 386 citations

Salazopyrin, a new sulfanilamide preparation. A. Therapeutic Results in Rheumatic Polyarthritis. B. Therapeutic Results in Ulcerative Colitis. C. Toxic Manifestations in Treatment with Sulfanilamide Preparations.

1942 • 358 citations

Methotrexate in psoriasis: Revised guidelines

1988 • 357 citations

Methotrexate and histologic hepatic abnormalities: A meta-analysis

1991 • 350 citations

Therapeutic suppression of tissue reactivity. II. Effect of aminopterin in rheumatoid arthritis and psoriasis.

1951 • 341 citations

Methotrexate-induced congenital malformations

1968 • 319 citations

Termination of slow acting antirheumatic therapy in rheumatoid arthritis: a 14 year prospective evaluation of 1017 consecutive starts

2001 • 293 citations

THERAPEUTIC SUPPRESSION OF TISSUE REACTIVITY

1951 • 284 citations

Lymphoproliferative cancer and other malignancy in patients with rheumatoid arthritis treated with azathioprine: a 20 year follow up study.

1988 • 274 citations

Malignancy following treatment of rheumatoid arthritis with cyclophosphamide

1987 • 271 citations

Methotrexate induced liver cirrhosis

1980 • 259 citations

The effect of folic acid supplementation on the toxicity of low‐dose methotrexate in patients with rheumatoid arthritis

1990 • 251 citations

Long‐Term Prospective Study of the Use of Methotrexate in the Treatment of Rheumatoid Arthritis

1992 • 248 citations

Remodeling the pyramid--a concept whose time has come.

1989 • 246 citations

Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis

1990 • 236 citations

The assessment and prediction of functional disability in rheumatoid arthritis.

1991 • 236 citations

Use of short‐term efficacy/toxicity tradeoffs to select second‐line drugs in rheumatoid arthritis. A metaanalysis of published clinical trials

1992 • 232 citations

Long‐Term Prospective Study of Methotrexate in the Treatment of Rheumatoid Arthritis

1992 • 227 citations

Determinants of serious liver disease among patients receiving low‐dose methotrexate for rheumatoid arthritis

1993 • 202 citations

Inhibition of in vitro vascular endothelial cell proliferation and in vivo neovascularization by low‐dose methotrexate

1989 • 202 citations

A Controlled Trial of Cyclophosphamide in Rheumatoid Arthritis

1970 • 201 citations

The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty‐five years of disease

1991 • 198 citations

The relative toxicity of disease‐modifying antirheumatic drugs

1993 • 183 citations

Comparison of auranofin, methotreaxate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial

1992 • 174 citations

Toxicity profiles of disease modifying antirheumatic drugs in rheumatoid arthritis.

1991 • 144 citations

Comparison of the Effect of Plasmapheresis and Penicillamine on the Level of Circulating Rheumatoid Factor

1963 • 143 citations

DIFFERENTIATING PERSISTENT FROM SELF-LIMITING SYMMETRICAL SYNOVITIS IN AN EARLY ARTHRITIS CLINIC

1993 • 142 citations

Low‐dose methotrexate with leucovorin (folinic acid) in the management of rheumatoid arthritis. results of a multicenter randomized, double‐blind, placebo‐controlled trial

1993 • 141 citations

Rheumatoid arthritis: Disappointing long-term outcomes despite successful short-term clinical trials

1988 • 137 citations

Sulfasalazine in early rheumatoid arthritis. A 48‐week double‐blind, prospective, placebo‐controlled study

1993 • 137 citations

Hydroxychloroquine Compared with Placebo in Rheumatoid Arthritis

1993 • 135 citations

The prognosis of rheumatoid arthritis and undifferentiated polyarthritis syndrome in the clinic: a study of 1141 patients.

1993 • 133 citations

Gold nephropathy a clinical and pathologic study

1970 • 133 citations

Comparison of Azathioprine, Cyclophosphamide, and Gold in Treatment of Rheumatoid Arthritis

1974 • 132 citations

Azathioprine in Rheumatoid Arthritis

1969 • 128 citations

Cyclosporin A in Severe, Treatment-Refractory Rheumatoid Arthritis

1988 • 121 citations

Adverse effects of low dose methotrexate therapy in rheumatoid arthritis.

1993 • 121 citations

Teratogenic effects of first-trimester cyclophosphamide therapy.

1988 • 119 citations

Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis

1992 • 119 citations

Methotrexate versus azathioprine in the treatment of rheumatoid arthritis. A forty‐eight–week randomized, double‐blind trial

1991 • 115 citations

Mechanisms of Methotrexate Action in Rheumatoid Arthritis

1994 • 106 citations

Methotrexate-associated hepatotoxicity: retrospective analysis of 210 patients with rheumatoid arthritis

1988 • 105 citations

Azathioprine in Rheumatoid Arthritis A Double‐Blind, Cross‐Over Study

1973 • 102 citations

Pancytopenia associated with low dose pulse methotrexate in the treatment of rheumatoid arthritis

1985 • 100 citations

The effects of drug therapy on radiographic progression of rheumatoid arthritis. results of a 36‐week randomized trial comparing methotrexate and auranofin

1993 • 100 citations

Acute and chronic suppression of leukotriene B₄ synthesis EX vivo in neutrophils from patients with rheumatoid arthritis beginning treatment with methotrexate

1992 • 97 citations

Acute pneumonitis associated with low dose methotrexate treatment for rheumatoid arthritis: report of five cases and review of published reports.

1992 • 95 citations

Antiproliferative effects of methotrexate on peripheral blood mononuclear cells

1989 • 93 citations

Influence of Methotrexate and Azathioprine on Radiologic Progression in Rheumatoid Arthritis

1991 • 92 citations

Natural course of penicillamine nephropathy: a long term study of 33 patients

1988 • 91 citations

Auranofin improves outcome in early rheumatoid arthritis. Results from a 2-year, double blind placebo controlled study.

1988 • 91 citations

Adverse experience with methotrexate during 176 weeks of a longterm prospective trial in patients with rheumatoid arthritis.

1990 • 91 citations

Liver biopsy findings in patients with rheumatoid arthritis undergoing longterm treatment with methotrexate.

1989 • 90 citations

Sulphasalazine: a safe, effective agent for prolonged control of rheumatoid arthritis. A comparison with sodium aurothiomalate.

1985 • 89 citations

Herpes zoster in patients with rheumatoid arthritis treated with weekly, low-dose methotrexate

1991 • 86 citations

Azathioprine in early rheumatoid arthritis

1977 • 83 citations

Incidence, prevalence and possible risk factors for pneumonitis in patients with rheumatoid arthritis receiving methotrexate.

1994 • 82 citations

Histopathologic findings in the liver of rheumatoid arthritis patients treated with long‐term bolus methotrexate

1988 • 79 citations

Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review.

1992 • 77 citations

Interaction of cyclosporine A and nonsteroidal anti-inflammatory drugs on renal function in patients with rheumatoid arthritis

1992 • 74 citations

Clinical liver disease in patients with rheumatoid arthritis taking methotrexate.

1992 • 68 citations

Are the results of controlled clinical trials and observational studies of second line therapy in rheumatoid arthritis valid and generalizable as measures of rheumatoid arthritis outcome: analysis of 122 studies.

1991 • 65 citations

Prospective analysis of liver biopsies before and after methotrexate therapy in rheumatoid patients

1989 • 64 citations

Abuse of Cyclopentolate Hydrochloride (Cyclogyl) Drops

1992 • 64 citations

Life table analysis of 879 treatment episodes with slow acting antirheumatic drugs in community rheumatology practice.

1992 • 64 citations

Cancer mortality in patients with rheumatoid arthritis.

1986 • 64 citations

COMBINED D-PENICILLAMINE AND CHLOROQUINE TREATMENT OF RHEUMATOID ARTHRITIS—A COMPARATIVE STUDY

1987 • 62 citations

Molecular mechanism of methotrexate action in inflammation

1992 • 62 citations

Serum aminoterminal propeptide of type III procollagen in psoriasis and psoriatic arthritis: Relation to liver fibrosis and arthritis

1991 • 60 citations

The clinical and health status of patients with recent‐onset rheumatoid arthritis

1991 • 58 citations

Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis.

1990 • 57 citations

Reduction of leukocyte and interleukin‐1β concentrations in the synovial fluid of rheumatoid arthritis patients treated with methotrexate

1993 • 57 citations

Herpes zoster in patients with rheumatoid arthritis treated with weekly, low-dose methotrexate

1991 • 51 citations

Time for changes in the design, analysis, and reporting of rheumatoid arthritis clinical trials

1990 • 51 citations

Radiographic assessment of disease progression in rheumatoid arthritis patients enrolled in the cooperative systematic studies of the rheumatic diseases program randomized clinical trial of methotrexate, auranofin, or a combination of the two

1993 • 50 citations

Effect of Parenterally Administered Gold Therapy on the Course of Adult Rheumatoid Arthritis

1991 • 49 citations

Gold sodium thiomalate compared to low dose methotrexate in the treatment of rheumatoid arthritis--a randomized, double blind 26-week trial.

1989 • 46 citations

Combination therapy in rheumatoid arthritis--no benefit of addition of hydroxychloroquine to patients with a suboptimal response to intramuscular gold therapy.

1993 • 46 citations

Treatment of Dysreaction Diseases with Nitrogen Mustards

1951 • 43 citations

Is methotrexate therapy for psoriasis carcinogenic? A modified retrospective-prospective analysis

1975 • 42 citations

Low dose methotrexate therapy for rheumatoid arthritis complicated by pancytopenia and Pneumocystis carinii pneumonia.

1991 • 42 citations

Long acting drug combinations in rheumatoid arthritis: a formal overview.

1991 • 41 citations

MEPACRINE AND RHEUMATOID ARTHRITIS

1952 • 38 citations

Acute, reversible hepatic failure associated with methotrexate treatment of rheumatoid arthritis.

1989 • 36 citations

A study of the longterm efficacy and toxicity of cyclosporine A in rheumatoid arthritis.

1991 • 36 citations

Pneumocystis carinii pneumonia associated with methotrexate therapy in rheumatoid arthritis.

1991 • 32 citations

Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate

1993 • 27 citations

Measurement of gold treatment effect in clinical practice: evidence for effectiveness of intramuscular gold therapy.

1993 • 26 citations

Dynamic hepatic scintigraphy in the screening of psoriatic patients for methotrexate-induced hepatotoxicity

1992 • 23 citations

Influence of previous gold toxicity on subsequent development of penicillamine toxicity.

1982 • 22 citations

LIVER BIOPSY VERSUS ULTRASOUND IN METHOTREXATE‐TREATED PSORIASIS: A DECISION ANALYSIS

1992 • 22 citations

Gold induced nephropathy in rheumatoid arthritis and HLA class II genes.

1993 • 21 citations

Pulmonary complications of antirheumatic drug therapy

1990 • 17 citations

The gold rush 1925-35.

1980 • 14 citations

Treatment of intractable rheumatoid arthritis with combined cyclophosphamide, azathioprine, and hydroxychloroquine. A follow-up study

1986 • 13 citations

Pulmonary cryptococcosis mimicking methotrexate pneumonitis.

1993 • 13 citations

A debate: Should patients with rheumatoid arthritis on methotrexate undergo liver biopsies?

1992 • 12 citations

AGGRESSIVE THERAPY DOES NOT SUBSTANTIALLY ALTER THE LONG-TERM COURSE OF RHEUMATOID ARTHRITIS

1993 • 11 citations

Gold vs D-penicillamine double blind study and followup.

1984 • 8 citations

SUSPECTED CUTANEOUS DRUG TOXICITY IN RHEUMATOID ARTHRITIS—AN EVALUATION

1993 • 7 citations