Protein Kinase C-mediated Gonadotropin-releasing Hormone Receptor Sequestration Is Associated with Uncoupling of Phosphoinositide Hydrolysis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Fluidity parameters of lipid regions determined by fluorescence polarization

1978 • 1,886 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Two dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines.

1979 • 759 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.

1988 • 455 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Studies on the reaction of fluorescamine with primary amines

1974 • 286 citations

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

1987 • 235 citations

Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.

1987 • 206 citations

Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester.

1984 • 206 citations

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

1985 • 199 citations

Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.

1986 • 194 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Conversion of a gonadotropin-releasing hormone antagonist to an agonist

1982 • 174 citations

Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes.

1980 • 173 citations

Novel aspects of gonadotropin-releasing hormone action on inositol polyphosphate metabolism in cultured pituitary gonadotrophs.

1987 • 169 citations

Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells.

1987 • 161 citations

Purification and characterization of a phosphoinositide-specific phospholipase C from guinea pig uterus. Phosphorylation by protein kinase C in vivo.

1987 • 161 citations

The Molecular Mechanism of Action of Gonadotropin Releasing Hormone (GnRH) in the Pituitary

1987 • 153 citations

A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide.

1985 • 151 citations

Molecular Mechanism of Gonadotropin Releasing Hormone Action. II. The Effector System*

1988 • 147 citations

Gonadotropin-Releasing Hormone Stimulates Mass Changes in Phosphoinositides and Diacylglycerol Accumulation in Purified Gonadotrope Cell Cultures*

1986 • 135 citations

Gonadotropin releasing hormone stimulation of cultured pituitary cells requires calcium.

1979 • 113 citations

LHRH and its analogs : contraceptive and therapeutic applications

1984 • 111 citations

Phorbol esters reduce gonadotrope responsiveness to protein kinase C activators but not to Ca2+-mobilizing secretagogues. Does protein kinase C mediate gonadotropin-releasing hormone action?

1987 • 110 citations

Stimulation of rat luteinizing hormone-beta messenger RNA levels by gonadotropin releasing hormone. Apparent role for protein kinase C.

1988 • 107 citations

Agonist-induced regulation of pituitary receptors for gonadotropin-releasing hormone. Dissociation of receptor recruitment from hormone release in cultured gonadotrophs.

1983 • 99 citations

Biphasic regulation of the gonadotropin-releasing hormone receptor by receptor microaggregation and intracellular Ca2+ levels.

1984 • 93 citations

Gonadotropin-releasing hormone activates a rapid Ca2+-independent phosphodiester hydrolysis of polyphosphoinositides in pituitary gonadotrophs.

1986 • 86 citations

The Relationship between Gonadotropin-Releasing Hormone-Stimulated Luteinizing Hormone Release and Inositol Phosphate Production: Studies with Calcium Antagonists and Protein Kinase C Activators*

1987 • 84 citations

Double-antibody method and the protein-A-bearing Staphylococcus aureus cells method compared for separating bound and free antigen in radioimmunoassay.

1979 • 77 citations

Inositol 1,4,5-trisphosphate binds to a specific receptor and releases microsomal calcium in the anterior pituitary gland.

1987 • 75 citations

Homologous Down-Regulation of Gonadotropin-Releasing Hormone Receptors and Desensitization of Gonadotropes: Lack of Dependence on Protein Kinase C

1987 • 72 citations

Triphosphoinositide increases glycoprotein lateral mobility in erythrocyte membranes

1982 • 66 citations

Stimulation of Luteinizing Hormone (LH) Release and Phospholipid Breakdown by Guanosine Triphosphate in Permeabilized Pituitary Gonadotropes: Antagonist Action Suggests Association of a G Protein and Gonadotropin-Releasing Hormone Receptor*

1986 • 64 citations

Gonadotropin releasing hormone stimulates the formation of inositol phosphates in rat anterior pituitary tissue

1985 • 63 citations

Use of lithium ion in measurement of stimulated pituitary inositol phospholipid turnover

1987 • 63 citations

Gonadotropin-releasing hormone binding to rat anterior pituitary membrane homogenates. Comparison of antagonists and agonists using radiolabeled antagonist and agonist.

1983 • 63 citations

Coincidence of down-regulation and desensitization in pituitary gonadotrophs stimulated by gonadotropin releasing hormone

1983 • 59 citations

Therapeutic Applications of Luteinizing-Hormone-Releasing Hormone and Its Analogs

1985 • 54 citations

Differential sensitivity of agonist- and antagonist-occupied gonadotropin-releasing hormone receptors to protein kinase C activators. A marker for receptor activation.

1988 • 54 citations

Subcellular Localization of the Receptor for Gonadotropin-Releasing Hormone in Pituitary and Ovarian Tissue*

1983 • 54 citations

Binding, internalization, and intracellular processing of protein ligands. Derivation of rate constants by computer modeling.

1987 • 53 citations

Photoaffinity Labeling of Pituitary and Gonadal Receptors for Gonadotropin-Releasing Hormone

1985 • 50 citations

Solubilization and purification of rat pituitary gonadotropin-releasing hormone receptor.

1986 • 50 citations

Gonadotropin releasing hormone enhances polyphosphoinositide hydrolysis in rat pituitary cells

1986 • 49 citations

Homologous Desensitization with Gonadotropin-Releasing Hormone (GnRH) also Diminishes Gonadotrope Responsiveness to Maitotoxin: A Role for the GnRH Receptor-Regulated Calcium Ion Channel in Mediation of Cellular Desensitization*

1987 • 48 citations

Phorbol diester modulates alpha-adrenergic receptor-coupled calcium efflux and alpha-adrenergic receptor number in cultured vascular smooth muscle cells.

1986 • 35 citations

Recognition of muscarinic cholinergic receptors in human SK-N-SH neuroblastoma cells by quaternary and tertiary ligands is dependent upon temperature, cell integrity, and the presence of agonists.

1988 • 33 citations

Membrane fluidity regulates development of gonadotrope desensitization to GnRH

1987 • 27 citations

Enhanced Responsiveness of Gonadotropes after Protein Kinase-C Activation: Postreceptor Regulation of Gonadotropin Releasing Hormone Action*

1988 • 27 citations

Receptor-mediated uptake of GnRH agonist and antagonists by cultured gonadotropes: Evidence for differential intracellular routing

1986 • 26 citations

Evidence of two steps in the homologous desensitization of vasopressin-sensitive phospholipase C in WRK1 cells. Uncoupling and loss of vasopressin receptors.

1988 • 24 citations

Biomembrane and receptor mechanisms

1987 • 24 citations

Effect of phorbol ester on stimulus-secretion coupling mechanisms in gonadotropin releasing hormone-stimulated pituitary gonadotrophs

1987 • 24 citations

[2] Preparation of radiolabeled neuroendocrine peptides

1983 • 24 citations

Covalent linking of photoreactive gonadotropin-releasing hormone to gonadotropes produces a prolonged signal.

1983 • 19 citations

Potentiation of specific association of insulin with HepG2 cells by phorbol esters

1986 • 17 citations

Attenuation of pituitary polyphosphoinositide metabolism by protein kinase C activation

1987 • 15 citations

[4] Photoaffinity labeling in neuroendocrine tissues

1983 • 14 citations

Protein kinase C increases the activity of the polyoma virus middle T antigen-associated phosphatidylinositol kinase

1988 • 13 citations

Phenylarsine oxide inhibits agonist-induced changes in photolabeling but not agonist-induced desensitization of the beta-adrenergic receptor.

1986 • 11 citations