Thyrotropin-Releasing Hormone Action: Mechanism of Calcium-Mediated Stimulation of Prolactin Secretion

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

1984 • 567 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions

1981 • 518 citations

Intracellular calcium; its universal role as regulator

1984 • 500 citations

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

1984 • 410 citations

Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.

1982 • 303 citations

Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.

1983 • 292 citations

Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Lipids in search of a function

1982 • 242 citations

Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action

1983 • 203 citations

Thyrotropin-releasing hormone-induced spike and plateau in cytosolic free Ca2+ concentrations in pituitary cells. Relation to prolactin release.

1984 • 192 citations

Thyrotropin-releasing hormone stimulates rapid loss of phosphatidylinositol and its conversion to 1,2-diacylglycerol and phosphatidic acid in rat mammotropic pituitary cells. Association with calcium mobilization and prolactin secretion.

1983 • 181 citations

Phospholipid Turnover in Hormone Action

1984 • 178 citations

Distinct patterns of cytoplasmic protein phosphorylation related to regulation of synthesis and release of prolactin by GH cells.

1983 • 172 citations

Inositol trisphosphate mediates thyrotropin-releasing hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells.

1984 • 168 citations

Thyrotropin-Releasing Hormone (TRH) Stimulates Biphasic Elevation of Cytoplasmic Free Calcium in GH₃Cells. Further Evidence that TRH Mobilizes Cellular and Extracellular Ca²⁺*

1985 • 143 citations

Membrane potential changes caused by thyrotropin-releasing hormone in the clonal GH3 cell and their relationship to secretion of pituitary hormone.

1979 • 137 citations

Biochemical Actions of Hormones

1978 • 135 citations

CALCIUM INFLUX IS NOT REQUIRED FOR TRH TO ELEVATE FREE CYTOPLASMIC CALCIUM IN GH₃CELLS

1983 • 133 citations

Thyrotropin releasing hormone

1982 • 124 citations

Is phosphatidylinositol really out of the calcium gate?

1982 • 121 citations

Role of calcium in the thyrotropin-releasing hormone-stimulated release of prolactin from pituitary cells in culture

1978 • 117 citations

Receptor-mediated release of plasma membrane-associated calcium and stimulation of calcium uptake by thyrotropin-releasing hormone in pituitary cells in culture.

1981 • 113 citations

Thyrotropin-Releasing Hormone (TRH) Selectively and Rapidly Stimulates Phosphatidylinositol Turnover in GH Pituitary Cells: A Possible Second Step of TRH Action*

1982 • 105 citations

Thyrotropin-releasing hormone rapidly and transiently stimulates cytosolic calcium-dependent protein phosphorylation in GH3 pituitary cells.

1982 • 102 citations

Tumor-Promoting Phorbol Esters Affect Production of Prolactin and Growth Hormone by Rat Pituitary Cells*

1981 • 98 citations

The origin, quantitation, and kinetics of intracellular calcium mobilization by vasopressin and phenylephrine in hepatocytes.

1983 • 97 citations

Voltage-dependent calcium channels in pituitary cells in culture. II. Participation in thyrotropin-releasing hormone action on prolactin release.

1984 • 97 citations

Thyrotropin-releasing hormone-induced changes in intracellular [Ca2+] measured by microspectrofluorometry on individual quin2-loaded cells.

1984 • 92 citations

Thyrotropin-releasing hormone-stimulated [3H]inositol metabolism in GH3 pituitary tumor cells. Studies with lithium.

1984 • 89 citations

Thyrotropin-releasing hormone stimulates rapid breakdown of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in GH3 pituitary tumor cells.

1984 • 78 citations

Evidence that Stimulation of Thyrotropin and Prolactin Secretion by Thyrotropin-Releasing Hormone Occur via Different Calcium-Mediated Mechanisms: Studies with Verapamil*

1982 • 75 citations

Ca2+ ionophores affect phosphoinositide metabolism differently than thyrotropin-releasing hormone in GH3 pituitary cells.

1984 • 72 citations

Thyrotropin-releasing hormone mobilizes Ca2+ from endoplasmic reticulum and mitochondria of GH3 pituitary cells: characterization of cellular Ca2+ pools by a method based on digitonin permeabilization.

1982 • 71 citations

Acute Stimulated Hormone Release from Cultured GH₃Pituitary Cells*

1978 • 68 citations

Mechanisms of Ca2+ transport in plasma membrane vesicles prepared from cultured pituitary cells. I. Characterization of Na+/Ca2+ exchange activity.

1984 • 66 citations

Thyrotropin releasing hormone stimulation of prolactin release. Evidence for a membrane potential-independent, Ca2+-dependent mechanism of action.

1980 • 65 citations

Thyrotropin-releasing Hormone Stimulation of Prolactin Release from Clonal Rat Pituitary Cells

1981 • 61 citations

Polyphosphoinositide hydrolysis by phospholipase C is accelerated by thyrotropin releasing hormone (TRH) in clonal rat pituitary cells (GH₃ cells)

1984 • 44 citations

Thyrotropin releasing hormone rapidly enhances [32P]orthophosphate incorporation into phosphatidic acid in cloned GH3 cells

1981 • 44 citations

Thyrotropin-releasing hormone causes loss of cellular calcium without calcium uptake by rat pituitary cells in culture. Studies using arsenazo III for direct measurement of calcium.

1982 • 42 citations

Thyrotropin releasing hormone stimulates metabolism of phosphatidyl inositol in GH₃ cells

1981 • 37 citations

Mechanisms of Ca2+ transport in plasma membrane vesicles prepared from cultured pituitary cells. II. (Ca2+ + Mg2+)-ATPase-dependent Ca2+ transport activity.

1984 • 31 citations

Evidence that cobalt ion inhibition of prolactin secretion occurs at an intracellular locus

1984 • 28 citations

On the role of extracellular Ca2+ for prolactin release and adenosine 3′:5′-monophosphate formation induced by thyroliberin in cultured rat pituitary cells

1980 • 28 citations

TETRACAIME, PROPRANOLOL AND TRIFLUOPERAZINE INHIBIT THYROTROPIN RELEASING HORMONE-INDUCED PROLACTIN SECRETION FROM GH³CELLS BY DISPLACING MEMBRANE CALCIUM: FURTHER EVIDENCE THAT TRH ACTS TO MOBILIZE CELLULAR CALCIUM

1982 • 27 citations

Calcium influx is not required for thyrotropin-releasing hormone stimulation of prolactin release from GH3 cells

1983 • 15 citations

Calcium-Dependent Changes in Electrical Properties of Prolactin-Secreting Anterior Pituitary (2B8) Clonal Cells

1981 • 14 citations

Calcium movements and intracellular calcium distribution in neoplastic GH3 cells

1983 • 6 citations