Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Apoptosis in development

2000 • 1,012 citations

Breaking the mitochondrial barrier

2001 • 947 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Role ofBAXin the Apoptotic Response to Anticancer Agents

2000 • 854 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Ceramide in the eukaryotic stress response

2000 • 729 citations

High-titer packaging cells producing recombinant retroviruses resistant to human serum

1995 • 672 citations

Apoptosis and the Dilemma of Cancer Chemotherapy

1997 • 615 citations

The Bax/Bcl-2 Ratio Determines the Susceptibility of Human Melanoma Cells to CD95/Fas-Mediated Apoptosis

2001 • 517 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore

1999 • 295 citations

Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

1995 • 295 citations

Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis

2000 • 283 citations

Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release

2000 • 280 citations

Ceramide Induces Cytochrome c Release from Isolated Mitochondria

1999 • 273 citations

Expression of Glucosylceramide Synthase, Converting Ceramide to Glucosylceramide, Confers Adriamycin Resistance in Human Breast Cancer Cells

1999 • 269 citations

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3

2001 • 248 citations

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.

1996 • 192 citations

Signal transduction pathways that regulate cell survival and cell death

1998 • 187 citations

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1998 • 186 citations

Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo

2000 • 175 citations

Analysis of the p53/BAX Pathway in Colorectal Cancer: Low BAX Is a Negative Prognostic Factor in Patients With Resected Liver Metastases

1999 • 174 citations

Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells

2000 • 156 citations

Dissecting the pathways to death

2000 • 155 citations

Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis

2001 • 147 citations

Cell death beyond apoptosis

2000 • 144 citations

Sphingomyelinases in cell regulation

1997 • 127 citations

Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.

1992 • 121 citations

Ceramide signalling: regulatory role in cell proliferation, differentiation and apoptosis in human epidermis

1997 • 115 citations

Analysis of p53/BAX/p16^ink4a/CDKN2 in Esophageal Squamous Cell Carcinoma: High BAX and p16^ink4a/CDKN2 Identifies Patients With Good Prognosis

2001 • 114 citations

Resistance to CD95/Fas‐induced and ceramide‐mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release

2000 • 98 citations

Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells

2000 • 97 citations

GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous Rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis

2000 • 77 citations

1α,25-Dihydroxyvitamin D3 Induces Sphingomyelin Hydrolysis in HaCaT Cells via Tumor Necrosis Factor α

1997 • 76 citations

Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation

2000 • 71 citations

Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl‐2, but not by CrmA

1997 • 70 citations

The vitamin D₃ analogue, calcipotriol, induces sphingomyelin hydrolysis in human keratinocytes

1996 • 62 citations

Bax‐dependent apoptosis induced by ceramide in HL‐60 cells

2001 • 62 citations

The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines

2002 • 61 citations

Activation of a nuclear sphingomyelinase in radiation induced apoptosis

2001 • 54 citations

Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosis.

2000 • 53 citations

ATM dependent apoptosis in the nervous system.

2000 • 52 citations

Bcl‐2 antagonizes apoptotic cell death induced by two new ceramide analogues

1997 • 36 citations

Lipid signaling in CD95‐mediated apoptosis

1999 • 30 citations

Ceramide-induced cell death in the prostate cancer cell line LNCaP has both necrotic and apoptotic features

2001 • 29 citations

Overexpression of the death‐promoting gene bax‐α sensitizes human BL‐41 Burkitt lymphoma cells for surface IgM‐mediated apoptosis

1997 • 10 citations

Reply

2000 • 2 citations

Normalverteilung

1993 • 2 citations