The clinical significance of inhibition of renal prostaglandin synthesis

Renal Syndromes Associated with Nonsteroidal Antiinflammatory Drugs

1984 • 1,098 citations

Selective Cumulative Inhibition of Platelet Thromboxane Production by Low-dose Aspirin in Healthy Subjects

1982 • 940 citations

Urinary prostaglandins. Identification and origin.

1975 • 485 citations

Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease.

1983 • 464 citations

Intrarenal prostaglandin release attenuates the renal vasoconstrictor activity of angiotensin.

1973 • 391 citations

Hydrodynamic Forces in Dissecting Aneurysms

1970 • 386 citations

Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin.

1977 • 351 citations

Effects of Sulindac and Ibuprofen in Patients with Chronic Glomerular Disease

1984 • 334 citations

Bartter's syndrome: A disorder characterized by high urinary prostaglandins and a dependence of hyperreninemia on prostaglandin synthesis

1976 • 321 citations

Prostaglandins: Modulators of Renal Function and Pressor Resistance in Chronic Liver Disease*

1979 • 288 citations

Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function

1985 • 235 citations

Immunohistochemical localization of the prostaglandin-forming cyclooxygenase in renal cortex

1978 • 232 citations

Prostaglandin synthesis by rat glomerular mesangial cells in culture. Effects of angiotensin II and arginine vasopressin.

1983 • 228 citations

Regional differences in the formation and metabolism of prostaglandins in the rabbit kidney

1973 • 223 citations

Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney.

1975 • 222 citations

Reduction of renal function by newer nonsteroidal anti-inflammatory drugs

1978 • 218 citations

Contribution of prostaglandins to the renal circulation in conscious, anesthetized, and laparotomized dogs.

1977 • 217 citations

Evidence for a Direct Stimulatory Effect of Prostacyclin on Renin Release in Man

1982 • 208 citations

Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus.

1985 • 200 citations

Indomethacin-Induced Prostaglandin Inhibition with Hyperkalemia

1979 • 185 citations

The disposition of sulindac

1977 • 166 citations

Identification of Risk for Renal Insufficiency From Nonsteroidal Anti-inflammatory Drugs

1983 • 161 citations

Prostaglandin synthesis in isolated rat kidney glomeruli.

1979 • 158 citations

Elevated Urinary Prostaglandins and the Effects of Aspirin on Renal Function in Lupus Erythematosus

1978 • 156 citations

Differential Efect of Noradrenaline and Renal Nerve Stimulation on Vascular Resistance in the Dog Kidney and the Release of a Prostaglandin E-Like Substance

1972 • 154 citations

Nonsteroidal Antiinflammatory Drugs and Renal Function

1984 • 135 citations

Renal Prostaglandins: Possible Regulators of the Renal Actions of Pressor Hormones

1970 • 134 citations

Kinin-induced prostaglandin synthesis by renal papillary collecting tubule cells in culture

1981 • 130 citations

EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON CONTROL OF HYPERTENSION BY BETA-BLOCKERS AND DIURETICS

1986 • 127 citations

Basal and stimulated rates of renal secretion and excretion of prostaglandins E2, Fα, and 13,14-dihydro-15-keto Fα in the dog

1978 • 125 citations

THE SYNOVIAL PROSTAGLANDIN SYSTEM IN CHRONIC INFLAMMATORY ARTHRITIS: DIFFERENTIAL EFFECTS OF STEROIDAL AND NONSTEROIDAL ANTI‐INFLAMMATORY DRUGS

1981 • 124 citations

Mechanism of action of glucocorticosteroids. Inhibition of T cell proliferation and interleukin 2 production by hydrocortisone is reversed by leukotriene B4.

1986 • 123 citations

Immunochemistry of prostaglandin endoperoxide-forming cyclooxygenases: The detection of the cyclooxygenases in rat, rabbit, and guinea pig kidneys by immunofluorescence

1977 • 120 citations

Renal prostaglandin synthesis: Sites of production and specific actions of prostaglandins

1986 • 118 citations

Release of renal prostaglandin by catecholamines: relationship to renal endocrine function.

1974 • 117 citations

Prostaglandin control of renal circulation in the unanesthetized dog and baboon

1975 • 111 citations

Effects of ibuprofen, naproxen, and sulindac on prostaglandins in men

1985 • 110 citations

Anti-inflammatory Agents as Inhibitors of Prostaglandin Synthesis in Man

1981 • 106 citations

Renal complications of nonsteroidal antiinflammatory drugs: Identification and monitoring of those at risk

1985 • 102 citations

The effect of arginine vasopressin and its analogs on the synthesis of prostaglandin E2 by rat renal medullary interstitial cells in culture.

1980 • 102 citations

Measurement of urinary 2,3-dinor-thromboxane B2 and thromboxane B2 using bonded-phase phenylboronic acid columns and capillary gas chromatography-negative-ion chemical ionization mass spectrometry

1985 • 100 citations

Altered renal and platelet arachidonic acid metabolism in cirrhosis

1986 • 98 citations

Prostaglandin and thromboxane synthesis by rat glomerular epithelial cells

1981 • 93 citations

Indomethacin potentiates the vasoconstrictor actions of angiotensin II in normal man

1976 • 90 citations

Pharmacokinetic-dynamic analysis of the indomethacin-furosemide interaction in man.

1980 • 89 citations

Effects of sulindac and ibuprofen in patients with cirrhosis and ascites

1986 • 85 citations

Prostaglandin synthesis in isolated glomeruli

1979 • 84 citations

Prostaglandin synthesis by mesangial and epithelial glomerular cultured cells

1979 • 83 citations

In vitro prostaglandin synthesis by human glomeruli and papillae

1982 • 82 citations

Effect of prostaglandin synthesis inhibitors on basal and carbon dioxide stimulated cerebral blood flow in man

1983 • 77 citations

Coronary flow regulation in patients with ischemic heart disease: release of purines and prostacyclin and the effect of inhibitors of prostaglandin formation.

1985 • 77 citations

Influence of Indomethacin on the Systemic and Pulmonary Vascular Resistance in Man

1978 • 77 citations

Sulindac Reduces the Urinary Excretion of Prostaglandins and Impairs Renal Function in Cirrhosis with Ascites

1986 • 73 citations

Prostaglandin synthesis by isolated rat renal glomeruli

1979 • 72 citations

Contribution of prostaglandins to the systemic and renal vascular response to frusemide in normal man.

1984 • 72 citations

Characterization of furosemide-induced activation of the renal prostaglandin system

1979 • 71 citations

Sulindac is not renal sparing in man

1985 • 71 citations

Effects of sulindac and indomethacin on renal prostaglandin synthesis

1984 • 70 citations

Evidence for a renal origin of urinary thromboxane B2 in health and disease.

1983 • 70 citations

The Effect of Sodium Restriction and Prostaglandin Inhibition on the Renin-Angiotensin System in Man*

1977 • 69 citations

Influence of non-steroidal anti-inflammatory drugs on diuretic treatment of mild to moderate essential hypertension.

1984 • 68 citations

Evidence for an extra-renal origin of urinary prostaglandin E2 in healthy men

1979 • 67 citations

Acute renal effects of sulindac and indomethacin in chronic renal failure

1985 • 65 citations

Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature.

1975 • 64 citations

Platelets in Glomerular Disease

1984 • 63 citations

Increased Synthesis of Systemic Prostacyclin in Cirrhotic Patients

1986 • 62 citations

Ibuprofen and sulindac kinetics in alcoholic liver disease

1983 • 59 citations

Stimulation of Renal Prostaglandin Synthesis by the Pressor Activity of Vasopressin*

1981 • 56 citations

Effect of indomethacin on glomerular permeability in the nephrotic syndrome

1979 • 56 citations

Effect of dexamethasone on in vivo prostanoid production in the rabbit.

1984 • 54 citations

Effects of nonsteroidal anti-inflammatory drugs in healthy subjects

1986 • 54 citations

Effect of prostaglandin synthetase inhibitors on renal blood flow in the rat

1976 • 54 citations

Renal Insufficiency Associated With Nonsteroidal Anti-inflammatory Agents

1984 • 52 citations

Different interactions of indomethacin and sulindac with thiazides in hypertension.

1982 • 51 citations

Incidence of hyperkalaemia induced by indomethacin in a hospital population.

1985 • 50 citations

Differential Effects of Selective and Non-Selective Prostaglandin-Synthesis Inhibition on the Pharmacological Responses to Captopril in Patients with Essential Hypertension

1982 • 50 citations

Indomethacin-furosemide interaction: the importance of renal blood flow.

1983 • 46 citations

The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients.

1984 • 45 citations

Differential effects of sulindac and indomethacin on blood pressure in treated essential hypertensive subjects

1985 • 43 citations

Reduction of urinary protein and prostaglandin E2 excretion in the nephrotic syndrome by non-steroidal anti-inflammatory drugs.

1986 • 43 citations

Fetal urinary prostaglandins

1982 • 42 citations

Non-Steroidal Anti-Inflammatory Drugs and Blood Pressure

1982 • 42 citations

Determinants and modification of adrenergic and vascular resistance in the kidney

1974 • 40 citations

Inflammation: The mediators of steroid action

1986 • 38 citations

Renal metabolism of sulindac: functional implications.

1984 • 36 citations

Sulindac and Indomethacin Suppress the Diuretic Action of Furosemide in Patients With Cirrhosis and Ascites: Evidence That Sulindac Affects Renal Prostaglandins

1985 • 35 citations

Acute and chronic effects of sulindac on renal function in chronic renal disease

1985 • 32 citations

Furosemide increases urine 6-keto-prostaglandin F1 alpha. Relation to natriuresis, vasodilation, and renin release.

1982 • 32 citations

Evidence that prostacyclin modulates the vascular actions of calcium in man.

1986 • 31 citations

Effects of sulindac on renal function and prostaglandin synthesis in patients with moderate chronic renal insufficiency

1986 • 26 citations

Comparison of the effects of sulindac with other cyclooxygenase inhibitors on prostaglandin excretion and renal function in normal and chronic bile duct-ligated dogs and swine.

1984 • 24 citations

Effect of indomethacin upon angiotensin‐induced changes in blood pressure and plasma aldosterone in normal man

1981 • 24 citations

Effect of aspirin and sulindac in rabbit nephrotoxic nephritis.

1986 • 24 citations

The renal excretion of prostaglandins and changes in plasma renin during treatment with either sulindac or naproxen in patients with rheumatoid arthritis and thiazide treated heart failure.

1984 • 23 citations

Role of prostaglandins in the renal handling of a salt load in essential hypertension

1985 • 22 citations

Effects of indomethacin and sulindac on blood pressure of hypertensive patients.

1986 • 22 citations

<b>THE LOCALIZATION OF PROSTAGLANDINS IN THE RABBIT KIDNEYS DEMONSTRATED WITH INDIRECT </b><b>IMMUNOFLUORESCENCE </b>

1981 • 21 citations

Urinary excretion of prostaglandin E like material and kallikrein: Effects of furosemide

1979 • 20 citations

Effect of CLINORIL (sulindac, MSD), piroxicam and placebo on the hypotensive effect of propranolol in patients with mild to moderate essential hypertension

1986 • 20 citations

Chemical renal medullectomy. Effect on urinary prostaglandin E2 and plasma renin in response to variations in sodium intake and in relation to blood pressure.

1983 • 19 citations

The involvement of arachidonic acid metabolism in the control of renin release

1980 • 17 citations

The role of prostaglandins in arterial hypertension: a critical review.

1985 • 14 citations

SYSTEMIC PROSTAGLANDIN I2 SYNTHESIS IS NORMAL IN PATIENTS WITH BARTTER'S SYNDROME

1983 • 14 citations

Effects of prostaglandin synthesis inhibitors on the renin-angiotensin system and renal function.

1985 • 13 citations

Sulindac and Ibuprofen Inhibit Furosemide-Stimulated Renin Release but not Natriuresis in Men on a Normal Sodium Diet

1985 • 13 citations

Diuretics and Kidney Prostaglandins

1983 • 12 citations

The effect of suppression of prostaglandin synthesis on renal function in rats with intact and reduced renal mass

1985 • 11 citations

Investigations of Renal Arachidonic Acid Metabolites by Radioimmunoassay

1983 • 11 citations

Biosynthesis and Metabolism of Prostaglandins in Human Kidney in Vitro

1983 • 9 citations

Renal hemodynamic effects of therapeutic plasma levels of sulindac sulfide during hemorrhage

1986 • 9 citations

Tissue‐selective inhibition of prostaglandin and thromboxane synthesis in man: investigative and therapeutic implications

1984 • 4 citations

Sulindac does not preserve renal prostacyclin synthesis during endotoxemia

1985 • 3 citations