Neurobiology of Early-Life Stress

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

1997 • 3,131 citations

Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood

2000 • 1,925 citations

Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat

1999 • 1,909 citations

Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats

1993 • 1,626 citations

Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat

1998 • 1,410 citations

The role of corticotropin-releasing factor in depression and anxiety disorders

1999 • 1,371 citations

Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report

1997 • 1,264 citations

Post-Traumatic Stress Disorder

2002 • 1,031 citations

Developmental traumatology part II: brain development∗∗See accompanying Editorial, in this issue.

1999 • 964 citations

Hippocampal volume in women victimized by childhood sexual abuse

1997 • 919 citations

Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60

1996 • 883 citations

Altered Pituitary-Adrenal Axis Responses to Provocative Challenge Tests in Adult Survivors of Childhood Abuse

2001 • 733 citations

Long-term behavioral and neuroendocrine adaptations to adverse early experience

2000 • 707 citations

Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder

1999 • 682 citations

Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.

1996 • 653 citations

Regional Cerebral Blood Flow During Script-Driven Imagery in Childhood Sexual Abuse-Related PTSD: A PET Investigation

1999 • 644 citations

Corticotropin-releasing factor, norepinephrine, and stress

1999 • 623 citations

Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans

1993 • 607 citations

The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat

2000 • 594 citations

Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder

1999 • 555 citations

Effects of early adverse experiences on brain structure and function: clinical implications

2000 • 509 citations

Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment

2001 • 504 citations

Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation.

1996 • 493 citations

Predicting the development of posttraumatic stress disorder from the acute response to a traumatic event

1998 • 472 citations

Influence of Neonatal Rearing Conditions on Stress‐Induced Adrenocorticotropin Responses and Norepinepherine Release in the Hypothalamic Paraventricular Nucleus

2000 • 446 citations

The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: A multiple regression analysis

2002 • 437 citations

Abuse-Related Posttraumatic Stress Disorder

1995 • 409 citations

Trauma in children and adolescents: risk and treatment of psychiatric sequelae

2002 • 405 citations

Naturally Occurring Differences in Maternal Care are Associated with the Expression of Oxytocin and Vasopressin (V1a) Receptors: Gender Differences

2002 • 403 citations

Gender differences in susceptibility to posttraumatic stress disorder

2000 • 355 citations

Enhanced Dexamethasone Suppression of Plasma Cortisol in Adult Women Traumatized by Childhood Sexual Abuse

1997 • 348 citations

The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors

2001 • 339 citations

Neurobiology of early life stress: Clinical studies

2002 • 300 citations

Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress

2001 • 239 citations

The corticotropin-releasing hormone test in patients with posttraumatic stress disorder

1989 • 233 citations

Relationship of Obstetric Complications and Differences in Size of Brain Structures in Monozygotic Twin Pairs Discordant for Schizophrenia

2000 • 207 citations

Childhood Attachment and Loss Experiences Affect Adult Cardiovascular and Cortisol Function

1998 • 186 citations

Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder

2001 • 183 citations

Adverse early experiences affect noradrenergic and serotonergic functioning in adult primates

1994 • 181 citations

Environmental stress and psychiatric illness

2000 • 154 citations

Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder

2001 • 152 citations

Childhood abuse experiences and combat-related PTSD

1994 • 150 citations

Psychophysiologic assessment of women with posttraumatic stress disorder resulting from childhood sexual abuse.

1998 • 135 citations

Serotonergic blunting to meta-chlorophenylpiperazine (m-CPP) highly correlates with sustained childhood abuse in impulsive and autoaggressive female borderline patients

2000 • 135 citations

Childhood abuse experiences and combat‐related PTSD

1994 • 115 citations

Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats

2001 • 99 citations

The Psychology of Stress and Coping

2000 • 93 citations

Endocrine Profile and Neuroendocrine Challenge Tests in Transgenic Mice Expressing Antisense RNA against the Glucocorticoid Receptor

1997 • 93 citations

Association of Serotonin and Cortisol Indices With Childhood Abuse in Bulimia Nervosa

2001 • 92 citations

Increased activity of the hypothalamus–pituitary–adrenal system after treatment with the mineralocorticoid receptor antagonist spironolactone

2000 • 81 citations

Response of adolescent bonnet macaques to an acute fear stimulus as a function of early rearing conditions

2001 • 70 citations

Regulation of a putative neurotransmitter effect of corticotropin-releasing factor: effects of adrenalectomy.

1997 • 59 citations

Regulation of a Putative Neurotransmitter Effect of Corticotropin-Releasing Factor: Effects of Adrenalectomy

1997 • 52 citations

DOMESTIC VIOLENCE

1993 • 50 citations

Negative Parenting Behavior, Combat Exposure, and PTSD Symptom Severity

1992 • 43 citations

Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 61–72

1996 • 39 citations

Sexual Dimorphism of the Human Stress Response May Be Due to Estradiol-Mediated Stimulation of Hypothalamic Corticotropin-Releasing Hormone Synthesis

1997 • 13 citations