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Effects of early adverse experiences on brain structure and function: clinical implications

Data up to Jan 2025

Published2000
Citations509
References126

Total Citations Per Year

Abstract

References (126)

J Neuropsychiatry Clin Neurosci

1992 • 3,756 citations

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

1997 • 3,131 citations

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis

1997 • 2,235 citations

Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat

1999 • 1,909 citations

Hippocampal atrophy in recurrent major depression.

1996 • 1,884 citations

Hippocampal Volume Reduction in Major Depression

2000 • 1,645 citations

Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats

1993 • 1,626 citations

MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder

1995 • 1,567 citations

Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat

1998 • 1,410 citations

Developmental Psychopathology: Risk, Disorder, and Adaptation

2006 • 1,381 citations

The role of corticotropin-releasing factor in depression and anxiety disorders

1999 • 1,371 citations

A functional anatomical study of unipolar depression

1992 • 1,266 citations

Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report

1997 • 1,264 citations

Handbook of infant mental health

2009 • 1,262 citations

Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons

1992 • 1,215 citations

Physiology and pharmacology of corticotropin-releasing factor.

1991 • 1,138 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Stressful life events, genetic liability, and onset of an episode of major depression in women

1995 • 1,057 citations

Cingulate function in depression

1997 • 1,034 citations

Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons

1990 • 1,013 citations

Handbook of infant mental health

2000 • 979 citations

Hippocampal volume in women victimized by childhood sexual abuse

1997 • 919 citations

Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder

1996 • 893 citations

The Dexamethasone Suppression Test for Melancholia

1982 • 774 citations

Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion

1996 • 737 citations

Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography

1988 • 729 citations

Long-term behavioral and neuroendocrine adaptations to adverse early experience

2000 • 707 citations

Stressors, Stress, and Neuroendocrine Integration of the Adaptive Response: The 1997 Hans Selye Memorial Lecture

1998 • 695 citations

PSYCHONEUROENDOCRINOLOGY OF DEPRESSION

1998 • 659 citations

The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety

1999 • 656 citations

Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.

1996 • 653 citations

Do early‐life events permanently alter behavioral and hormonal responses to stressors?

1998 • 651 citations

Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy

1999 • 610 citations

Psychiatric morbidity in adult inpatients with childhood histories of sexual and physical abuse

1991 • 599 citations

The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazepine Receptor Levels and Novelty-Induced Fearfulness in the Rat

2000 • 594 citations

Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study

2000 • 567 citations

Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress

1995 • 564 citations

Developmental Psychopathology

1996 • 564 citations

Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone

2000 • 559 citations

Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims

1988 • 547 citations

Catecholaminergic Modulation of Corticotropin-Releasing Factor and Adrenocorticotropin Secretion

1989 • 536 citations

Neurobiology of Mental Illness

2011 • 532 citations

Prefrontal cortical projections to the hypothalamus in Macaque monkeys

1998 • 521 citations

Neurotoxicity of Glucocorticoids in the Primate Brain

1994 • 519 citations

Breaking the Cycle of Abuse

1988 • 513 citations

Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in Macaque monkeys

1998 • 507 citations

Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation.

1996 • 493 citations

Amygdala core nuclei volumes are decreased in recurrent major depression

1998 • 471 citations

Influence of Neonatal Rearing Conditions on Stress‐Induced Adrenocorticotropin Responses and Norepinepherine Release in the Hypothalamic Paraventricular Nucleus

2000 • 446 citations

Breaking the Cycle of Abuse

1988 • 419 citations

Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression

1998 • 401 citations

Stress-Induced Norepinephrine Release in the Hypothalamic Paraventricular Nucleus and Pituitary-Adrenocortical and Sympathoadrenal Activity: In Vivo Microdialysis Studies

1995 • 394 citations

Quantitative MRI of the hippocampus and amygdala in severe depression

2000 • 377 citations

Neural circuits mediating stress

1999 • 366 citations

Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study

2000 • 360 citations

Depressive Disorders in Maltreated Children

1991 • 358 citations

The role of corticotropin-releasing factor–norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress

1999 • 358 citations

Neurobiology of Mental Illness.

2000 • 344 citations

Early Sexual Abuse and Clinical Depression in Adult Life

1991 • 341 citations

Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders

1998 • 341 citations

Serotonin and Hippocampal Neurogenesis

1999 • 331 citations

Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress

1999 • 329 citations

Effect of sertraline on regional metabolic rate in patients with affective disorder

1997 • 310 citations

Parenting: a genetic-epidemiologic perspective

1996 • 308 citations

Responses to maternal separation : mechanisms and mediators

1998 • 285 citations

Hypercortisolemia and hippocampal changes in depression

1993 • 284 citations

Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression

1993 • 277 citations

Differential rearing affects corpus callosum size and cognitive function of rhesus monkeys

1998 • 277 citations

STRESS AND THE DEVELOPING LIMBIC–HYPOTHALAMIC–PITUITARY–ADRENAL AXIS

1998 • 273 citations

Adaptation to Prolonged or Repeated Stress – Comparison between Rat Strains Showing Intrinsic Differences in Reactivity to Acute Stress

1997 • 259 citations

The dexamethasone suppression test: an overview of its current status in psychiatry. The APA Task Force on Laboratory Tests in Psychiatry

1987 • 259 citations

A Functional Neuroanatomy of Anxiety and Fear: Implications for the Pathophysiology and Treatment of Anxiety Disorders

1996 • 255 citations

Neuropeptide Concentrations in the Cerebrospinal Fluid of Depressed Patients Treated with Electroconvulsive Therapy

1991 • 253 citations

Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats

1991 • 251 citations

A profile of violence toward children: A national study

1993 • 242 citations

A Developmental Model of Childhood Traumatic Stress

2013 • 231 citations

A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys

1989 • 212 citations

The Role of Early Adverse Life Events in the Etiology of Depression and Posttraumatic Stress Disorder

1997 • 196 citations

The intergenerational transmission of child abuse

1989 • 196 citations

Regulation of Neuronal Birth, Migration and Death in the Rat Dentate Gyrus

1996 • 195 citations

The effects of neonatal stress on brain development: Implications for psychopathology

1999 • 193 citations

The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: genetic and maternal factors

1996 • 183 citations

Adverse early experiences affect noradrenergic and serotonergic functioning in adult primates

1994 • 181 citations

Mother-infant attachment in the squirrel monkey: Adrenal response to separation

1978 • 176 citations

The role of placement experiences in mediating the criminal consequences of early childhood victimization.

1991 • 169 citations

Hypothalamic-pituitary-adrenal axis

1994 • 166 citations

Early developmental and temporal characteristics of stress-induced secretion of pituitary-adrenal hormones in prenatally stressed rat pups

1991 • 162 citations

Early Stress and Adult Emotional Reactivity in Rhesus Monkeys

2007 • 157 citations

Maternal separation followed by early social deprivation affects the development of monoaminergic fiber systems in the medial prefrontal cortex of Octodon degus

1999 • 152 citations

Prevention of stress-induced morphological and cognitive consequences

1997 • 139 citations

Early and Later Adoptions Have Different Long-Term Effects on Male Rat Offspring

1996 • 134 citations

THE INFLUENCE OF CHILDHOOD DISCIPLINARY EXPERIENCE ON THE DEVELOPMENT OF ALCOHOLISM AND DEPRESSION

1987 • 131 citations

Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: A putative role for corticotropin-releasing factor

1993 • 130 citations

Molecular basis for the development of individual differences in the hypothalamic-pituitary-adrenal stress response

1993 • 127 citations

Parallel circuits for emotional coping behaviour: New pieces in the puzzle

1998 • 119 citations

Activation of the Locus Ceruleus Brain Noradrenergic System during Stress: Circuitry, Consequences, and Regulation

1997 • 118 citations

Temporal lobe measurement in primary affective disorder by magnetic resonance imaging

1989 • 118 citations

Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3α, 5α- tetrahydroprogesterone (allopregnanolone) availability?

1998 • 113 citations

Periaqueductal gray matter projection to the parabrachial nucleus in rat

1998 • 110 citations

Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF.

1996 • 110 citations

CSF amine metabolites in depression

1992 • 107 citations

Corticotropin-releasing factor up-regulates its own receptor mRNA in the paraventricular nucleus of the hypothalamus

1996 • 106 citations

The Neurobiological Basis of Anxiety and Fear: Circuits, Mechanisms, and Neurochemical Interactions (Part II)

1998 • 97 citations

Discrete local application of corticotropin-releasing factor increases locus coeruleus discharge and extracellular norepinephrine in rat hippocampus

1999 • 96 citations

Gender specificity in the neural regulation of the response to stress

1998 • 93 citations

Reduced glucose metabolism in the subgenual prefrontal cortex in unipolar depression

1998 • 92 citations

The Role of Limbic and Hypothalamic Corticotropin‐Releasing Factor in Behavioral Responses to Stress

1993 • 89 citations

Blunted aldosterone and ACTH release after human CRH administration in depressed patients

1987 • 86 citations

Temporal and social factors influencing behavioral and hormonal responses to separation in mother and infant squirrel monkeys

1993 • 82 citations

Central corticotropin-releasing hormone receptors modulate hypothalamic–pituitary–adrenocortical and sympathoadrenal activity during stress

1999 • 81 citations

GABA Physiology: Modulation by Benzodiazepines and Hormones

1996 • 76 citations

Long‐term behavioural and neuroendocrine changes in roman HIGH‐(RHA/Verh) and LOW‐(RLA‐Verh) avoidance rats following neonatal handling

1998 • 73 citations

Children, families, and government : preparing for the twenty-first century

1996 • 71 citations

The Dexamethasone Suppression Test

1983 • 66 citations

Gene chips and arrays revealed: a primer on their power and their uses

1999 • 65 citations

Serotonin and Hippocampal Neurogenesis

1999 • 63 citations

Serotonin, Anxiety, and Stress Hormones: Focus on 5-HT Receptor Subtypes, Species and Gender Differencesa

1998 • 57 citations

Influence of postnatal rearing conditions on the response of squirrel monkey infants to brief perturbations in mother-infant relationships☆

1987 • 47 citations

Abnormal acth and cortisol responses to ovine corticotropin releasing factor in patients with primary affective disorder

1986 • 45 citations

Exposure to violence and early childhood trauma

2000 • 43 citations

Maternal separation and early social deprivation in octodon degus: quantitative changes of nicotinamide adenine dinucleotide phosphate-diaphorase-reactive neurons in the prefrontal cortex and nucleus accumbens

1999 • 38 citations

Intensive Intervention for Maltreated Infants and Toddlers in Foster Care

1998 • 32 citations

Psychopathology in the relatives of depressed-abused children

1998 • 26 citations

COMIT

1995 • 5 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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Effects of early adverse experiences on brain structure and function: clinical… (2000) – Biological Psychiatry | Metascience Observatory Explorer