Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells

Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin

1989 • 833 citations

Growth of factor-dependent hemopoietic precursor cell lines.

1980 • 793 citations

Signaling Through the Hematopoietic Cytokine Receptors

1995 • 617 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.

1993 • 383 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

Cytokine Receptors and Signal Transduction

1997 • 259 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

Serine/threonine phosphorylation in cytokine signal transduction

2000 • 199 citations

Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors.

1985 • 173 citations

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene

1996 • 156 citations

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

1999 • 151 citations

The role of TEL fusion genes in pediatric leukemias

1999 • 122 citations

Craf-1 protein kinase is essential for mouse development

1998 • 116 citations

Overexpression of Protein Kinase C Isoform  but not δ in Human Interleukin-3–Dependent Cells Suppresses Apoptosis and Induces bcl-2 Expression

1998 • 114 citations

Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism

1991 • 112 citations

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1998 • 100 citations

The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

1998 • 94 citations

The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements.

1994 • 92 citations

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

2000 • 90 citations

Cell-Surface Differentiation in the Mouse

1980 • 86 citations

Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1

1997 • 76 citations

A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells

2000 • 76 citations

A Phosphatidylinositol 3-Kinase-dependent Pathway That Differentially Regulates c-Raf and A-Raf

1999 • 73 citations

The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression.

1991 • 60 citations

Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene.

1993 • 54 citations

Characterization of Subsets of Bone Marrow-Derived Macrophages by Flow Cytometry Analysis

1985 • 53 citations

Abrogation of factor-dependence in two IL-3-dependent cell lines can occur by two distinct mechanisms.

1989 • 48 citations

Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells

2000 • 48 citations

The effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor.

1994 • 39 citations

Oncogenic effects of overexpression of the interleukin-3 receptor on hematopoietic cells.

1996 • 38 citations

Retroviral infection can abrogate the factor-dependency of hematopoietic cells by autocrine and non-autocrine mechanisms depending on the presence of a functional viral oncogene.

1993 • 37 citations

Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells

2000 • 35 citations

Regulation of the interleukin-3 (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line

1994 • 27 citations

Abnormal activation of cytokine gene expression by intracisternal type A particle transposition: effects of mutations that result in autocrine growth stimulation and malignant transformation.

1997 • 25 citations

Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells

2000 • 24 citations

Constitutive Expression of the Promyelocytic Leukemia–Associated Oncogene PML-RARα in TF1 Cells: Isoform-Specific and Retinoic Acid–Dependent Effects on Growth, bcl-2 Expression, and Apoptosis

1998 • 24 citations

DIFFERENTIAL-EFFECTS OF VIRAL AND CELLULAR ONCOGENES ON THE GROWTH FACTOR-DEPENDENCY OF HEMATOPOIETIC-CELLS

1995 • 19 citations

Regulation of interleukin 3 expression in normal and autocrine transformed hematopoietic cells (Review)

1997 • 15 citations

AUTOCRINE GROWTH-FACTOR SECRETION AFTER TRANSFORMATION OF HUMAN CYTOKINE-DEPENDENT CELLS BY VIRAL AND CELLULAR ONCOGENES

1995 • 11 citations

Cytokine-dependent engraftment of human myeloid leukemic cell lines in immunosuppressed nude mice.

1994 • 11 citations

Autocrine transformation of human hematopoietic cells after transfection with an activated granulocyte/macrophage colony stimulating factor gene.

1997 • 11 citations